Effect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological study

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dc.contributor.authorAktürk, Zeynep
dc.contributor.authorOdacı, Ersan
dc.contributor.authorİkinci, Ayşe
dc.contributor.authorBaş, Orhan
dc.contributor.authorCanpolat, Sinan
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorSönmez, Osman Fikret
dc.date.accessioned2020-05-01T09:11:40Z
dc.date.available2020-05-01T09:11:40Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000336959100003en_US
dc.descriptionPubMed: 25551920en_US
dc.description.abstractBackground/aim: This study investigated the effect of Ginkgo biloba (GB) on brain volume in cerebral ischemia induced by stopping carotid artery blood flow. Materials and methods: Twenty-four adult male rats were divided into 4 groups of 6 rats each. No procedure was performed on the control group. Ischemia was applied to the rats in the ischemia and ischemia + GB groups by clamping the arteria carotis communis for 30 min. The rats in the ischemia + GB group were given 100 mg/kg drops (Tebokan Fort Drop, Abdi Ibrahim Ilac Sanayi A.S., Turkey) containing dry GB leaf extract orally, every day for 14 days from the day of ischemia. In the sham group, surgical stress alone was applied by performing a skin incision. On the 14th day, brain tissues were extracted and evaluated stereologically and histopathologically. Results: The only statistically significant difference was observed between the sham and control groups. Conclusion: This result may be interpreted as surgical stress, established by cutaneous incision, having an adverse effect on brain volume. Additionally, the absence of any difference in terms of brain volume following 30 min of ischemia between the ischemia and control groups suggests that a probable postischemic rise in brain volume disappears within 14 days.en_US
dc.identifier.doi10.3906/sag-1305-40en_US
dc.identifier.endpage553en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage546en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1305-40
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5712
dc.identifier.volume44en_US
dc.identifier.wosWOS:000336959100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGinkgo bilobaen_US
dc.subjectbrainen_US
dc.subjectischemiaen_US
dc.subjectraten_US
dc.subjectstereologyen_US
dc.titleEffect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological studyen_US
dc.typeArticleen_US

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