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Öğe Queen bee larvae (Apis mellifera) as a novel bioactive matrix: tyrosinase inhibition, compositional analysis, and formulation evaluation(Taylor&Francis, 2026) Dikmen Küçük, Sibel; Jabet, Paul; Groso, Anthony; Collet, Guillaume; Daniellou, Richard; Kekecoglu, Meral; Onder, ElifQueen bee larvae (QBL), a by-product of Apis mellifera royal jelly production, represent an underexplored protein-rich biological matrix with enzyme-modulatory bioactivity. This study provides the first systematic characterisation of lyophilised QBL through compositional profiling, tyrosinase inhibitory activity, cytocompatibility assessment, and topical carrier stability evaluation. Compositional analysis (AOAC/ISO-accredited methods) revealed a proteindominant matrix (55.19 g/100 g) rich in essential amino acids, B-group vitamins, vitamins C, D3 and E, and minerals (Mg 1566 mg/ kg; Ca 676.6 mg/kg), with total antioxidant capacity of 312.1 ?M Trolox equivalents. QBL demonstrated concentration-dependent human tyrosinase inhibition, reaching 75.7 ± 2.5% at 1000 ?g/mL. HaCaT keratinocyte viability exceeded 80% across all concentrations at 24 h and 48 h. A QBL-incorporated model gel maintained physicochemical integrity and microbiological stability over three months. These findings establish QBL as a biocompatible, protein-dominant natural matrix with tyrosinase-modulatory and antioxidant properties, warranting further investigation as a bioactive natural product.Öğe The Potential of Tempo-Oxidized Cellulose Nanofibers to Replace Ethylene-Propylene-Diene Monomer Rubber(World Academy of Science, Engineering and Technology, 2020) Dikmen Küçük, Sibel; Tozluoglu, A.; Guner, Y.In recent years, petroleum-based polymers began to be limited due to effects on human and environmental point of view in many countries. Thus, organic-based biodegradable materials have attracted much interest in the composite industry because of environmental concerns. As a result of this, it has been asked that inorganic and petroleum-based materials should be reduced and altered with biodegradable materials. In this point, in this study, it is aimed to investigate the potential of use of TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl)-mediated oxidation nano-fibrillated cellulose instead of EPDM (ethylene-propylene-diene monomer) rubber, which is a petroleum-based material. Thus, the exchange of petroleum-based EPDM rubber with organic based cellulose nanofibers, which are environmentally friendly (green) and biodegradable, will be realized. The effect of tempo-oxidized cellulose nanofibers (TCNF) instead of EPDM rubber was analyzed by rheological, mechanical, chemical, thermal and aging analyses. The aged surfaces were visually scrutinized and surface morphological changes were examined via scanning electron microscopy (SEM). The results obtained showed that TEMPO oxidation nano-fibrillated cellulose can be used at an amount of 1.0 and 2.2 phr resulting the values stay within tolerance according to customer standard and without any chemical degradation, crack, colour change or staining.Öğe COMBINING HIGH-FIDELITY SIMULATION AND STANDARDIZED PATIENT SIMULATION AS A HYBRID TEACHING STRATEGY: EFFECTS ON NURSING STUDENTS' ANXIETY, KNOWLEDGE, AND SKILLS(Nobel Ilac, 2026) Erbas, Atiye; Celik, Sevilay SenolObjective: The aim of this study was to determine the effects of high-fidelity simulation and hybrid methods on the anxiety levels, knowledge, and skills of nursing students providing postoperative care to patients with cervical spinal trauma. Material and Method: This quasi-experimental, prospective, controlled study included 48 senior nursing students, who were divided into three groups (control, simulation, and hybrid). Study data were collected using the State-Trait Anxiety Inventory, knowledge forms, and skill assessment forms. Data were analyzed using the paired t-tests, two-factor MANOVA, and one-way ANOVA. Results: The results indicated significant improvements in trait anxiety and knowledge scores before and after training, as well as after the simulation application (p<0.05), for both the simulation and hybrid groups. Changes in state anxiety (F=22.365, p<0.001), trait anxiety (F=4.637, p=0.014), and knowledge scores (F=78.371, p<0.001) were significant independent of group, and within-group analyses showed that both groups benefited from the intervention. Additionally, the hybrid group achieved higher mean practice scores than the simulation group after the simulation application (t=- 2.84, p=0.008). Conclusion: Although the study found all simulation methods effective in improving knowledge, the hybrid simulation method was more effective in improving skills. Hybrid simulation methods involving standardized patients should be considered a particularly effective teaching approach in surgical nursing education to prepare nursing students for their future professional practice.Öğe Investigation of the Relationships Among Maternal Anxiety, Infantile Colic and Sociodemographic Characteristics of the Family(Medcom Ltd, 2026) Kurt, F.; Teberik, C.; Kaya, A.Introduction: Infantile colic (IC) is a functional gastrointestinal disorder characterised by excessive crying episodes during the first months of life with an unknown aetiology. Despite the absence of identifiable organic pathology, IC may lead to psychological problems such as anxiety and depression, particularly in mothers, and can adversely affect parent-infant interactions. This study aimed to investigate the associations between maternal anxiety levels during pregnancy and the development of infantile colic, as well as the potential influence of certain paternal risk factors. Methodology: In this prospective observational study, a total of 210 mother-infant pairs were evaluated. Maternal gestational age and sociodemographic characteristics were recorded, and the Beck Anxiety Inventory (BAI) was administered during pregnancy. Between the 5th and 8th weeks postpartum, mothers were contacted via telephone to assess signs of infantile colic in their babies. For suspected IC cases, parents were asked to keep a crying diary, and the infants were invited to the clinic for physical examination and laboratory evaluation. Infants meeting Wessel's criteria were diagnosed with IC. Results: Infantile colic was significantly more prevalent among infants whose mothers experienced high levels of anxiety during pregnancy. Furthermore, the incidence of IC was greater in infants whose fathers smoked or consumed alcohol. Mothers who had previously had a child diagnosed with IC reported higher anxiety scores. Cesarean delivery rates were also elevated among mothers with high anxiety levels. Conclusion: This study suggests that maternal anxiety during pregnancy may be a significant risk factor for the development of infantile colic. Additionally, environmental and behavioral factors related to the father may also contribute to the aetiology of IC. These findings highlight the importance of psychosocial interventions targeting both maternal and paternal factors.Öğe Optimizing Peripheral Nerve Blocks for Headache Management: Does the Choice of Agent Matter?(Sage Publications Ltd, 2025) Oksuz, Nevra; Uluduz, Derya; Sucu, Damla Hazal; Azorin, David Garcia; Yolcu, Ozum; Gulec, M. Sacit; Ozge, Aynur[Abstract Not Available]Öğe Examining the relationship between taekwondo coaches' attitudes towards coaching and their self-esteem(Univ Murcia, 2026) Sadik, Resat; Pepe, SirinThis study aimed to examine the relationship between taekwondo coaches' attitudes toward the coaching profession and their self-esteem. The sample consisted of a total of 106 coaches, including 31 females (29.2%) and 75 males (70.8%). In addition to a demographic information questionnaire developed by the researchers, the Attitude Scale Toward the Coaching Profession, and the Rosenberg Self-Esteem Scale and adapted into Turkish were used. The research was conducted using a relational survey model. Since the data did not show a normal distribution according to the statistical analyses, non-parametric statistical methods were employed. Research findings revealed that there is a positive and moderately significant relationship between self-esteem and attitudes towards the coaching profession (p<0.05). This shows that coaches with high self-esteem develop more positive attitudes towards their profession, and this situation is related to multidimensional psychosocial variables such as professional motivation, communication skills, leadership qualities, and general life satisfaction. The fact that female coaches exhibit more positive results, particularly in the behavioral attitude dimension, also raises the need for more in-depth analysis of gender roles. Such findings highlight the fact that the coaching profession should be based not only on technical knowledge but also on psychological and social dimensions.Öğe Effect of Toxoplasma Gondii Infection on Idiopathic Epilepsy; the Role of MicroRNAs(Wiley, 2026) Soyturk, Hayriye; Demir, Serif[Abstract Not Available]Öğe Novel Variants in F10 and DMGDH Genes in a Child with Mild Factor X Deficiency and Familial Episodic Pain Syndrome(Medcom Ltd, 2026) Cakmak, H. M.Purpose: To describe the clinical, laboratory, genetic, and familial features of a child with mild factor X deficiency and associated multisystem findings. Methods: A 6-year-old boy with daily epistaxis underwent coagulation testing, family evaluation, pedigree analysis, and exome sequencing. Findings: Prothrombin time was prolonged, activated partial thromboplastin time was normal, and factor X activity was 20.3%. The father and sister also had prolonged prothrombin time, supporting familial inheritance. Exome sequencing identified a novel heterozygous F10 variant, F10 (NM_000504.4):c.785G>A, p.(Gly262Asp), classified as likely pathogenic. Additional variants were detected in DMGDH, TRPA1, and TNFRSF13B, correlating with fish-like odor with muscle fatigue and familial episodic pain. No immunological work-up, including serum immunoglobulin measurements, was available in this report; therefore, the TNFRSF13B finding was interpreted cautiously and was not considered diagnostic of CVID or another primary immunodeficiency. Pedigree analysis showed recurrent bleeding and episodic pain on the paternal side. Conclusions: This case expands the molecular spectrum of F10-related disease and supports exome-based evaluation in families with bleeding and multisystem phenotypes when routine coagulation studies and family history suggest a broader inherited disorder in affected relatives.Öğe Long-term metabolic and safety profiles of tenofovir alafenamide and tenofovir disoproxil fumarate in HIV treatment: a multicenter retrospective study using mixed-effects modeling(Wiley, 2025) Karabay, O.; Vatan, A.; Ucar, A.; Yilmaz, I.; Balta, N. C.; Kanturk, A.; Guclu, E.[Abstract Not Available]Öğe Machine learning analysis of predictors for the development of severe erectile dysfunction after penile fracture repair(Elsevier, 2025) Geyik, S.; Yilmaz, I. O.; Deger, M.; Kankilic, N. A.; Yilmaz, O.; Kavak, R.; Bozkurt, O.[Abstract Not Available]Öğe Imipramine regulates cellular survival by inducing endoplasmic reticulum stress in cervical cancer cells(Wiley, 2025) Kar, E.; Kar, F.; Hacioglu, C.[Abstract Not Available]Öğe Visual snow syndrome without headache: a case report(BMC, 2025) Ozyilmaz, Aysegul; Polat, Burcu[Abstract Not Available]Öğe Sex Estimation Based on Optical Channel Parameters from Computed Tomography Images with Machine Learning Algorithms(Soc Chilena Anatomia, 2025) Ozturk, Oguzhan; Harmandaoglu, Oguzhan; Kaya, Seren; Secgin, Yusuf; Senol, Deniz; Colakoglu, Serdar; Onbas, OmerThe skull is one of the most dimorphic and anatomically informative bones for sex estimation and shows resistance to taphonomic processes. This study aims to estimate sex using machine learning (ML) algorithms based on morphometric measurementof the optic canal (OC)-a clinically significant canal within the sphenoid bone that transmits the optic nerve and ophthalmicrtery. aThis retrospective study was conducted on CT from 260 adults (130 females and 130 males, aged 18-65). The images were obtained from the PACS archive of the Department of Radiology, Faculty of Medicine, D & uuml;zce University, covering the years 2019 to 2025.Sixteen bilateral morphometric parameters of the temporal bone were measured in axial and coronal planes. Data were analysed oususing vari ML algorithms, and classification performance was compared. On the 20 % test set, ML models achieved over 81 % accuracy;icLogist Regression performed best with 90 %. In 10-fold cross-validation, all algorithms exceeded 74 %, with LR again reaching theest highat 89 %. Decision Tree yielded the lowest accuracy. SHapley Additive exPlanations (SHAP), which facilitates interpretable machinelearning, revealed that the right-sided OC-midsagittal distance had the greatest predictive impact. Morphometric data from the OChighprovide accuracy and strong potential for sex estimation. The study also highlights sex-and population-based variation in OC Theseposition. findings may be relevant in clinical and forensic contexts, particularly in forensic anthropology, ophthalmology, and legalmedicine.Öğe The effect of prolonged ischemia and anesthetic agents on oxidative stress parameters, postoperative pain, and postoperative analgesia requirement(Wiley, 2025) Yorulmaz, I. S.; Arican, M.; Sezen, G.; Alpay, M.[Abstract Not Available]Öğe Investigating the Content of stereotypes of men subgroups in Turkey and their link to ambivalent sexism toward men(Hogrefe Ag-Hogrefe Ag Suisse, 2025) Karagenc, Kardelen; Oghan, Basak Gencturk; Sakalli, Nuray[Abstract Not Available]Öğe Timing Intervals and Repetition of Peripheral Nerve Blocks in the Management of Refractory Headaches(Sage Publications Ltd, 2025) Oksuz, Nevra; Uluduz, Derya; Sucu, Damla Hazal; Vuralli, Doga; Arvaniti, Chryssa; Dikmen, Pinar Yalinay; Ozge, Aynur[Abstract Not Available]Öğe Reliability and validity of Turkish version of migraine specific quality of life v2.1 questionnaire(Bmc, 2025) Dikmen, P. Yalinay; Misir, A. Sahin; Aydinlar, E. Ilgaz; Soyukibar, T. Erdogan; Ozge, A.; Karaci, R.; Tasdelen, B.[Abstract Not Available]Öğe Investigation of stage-specific exosomal content in small cell lung cancer by multiomics approach and investigation of possible effects in organotropic in vivo SCID mouse model(Wiley, 2025) Inci, K.; Tokgun, O.; Eylem, C. C.; Nemutlu, E.; Gultekin, A.[Abstract Not Available]Öğe THE ROLE OF RURAL TOURISM IN DEVELOPMENT: THE AKCAKOCA EXAMPLE, Turkiye(Univ Agronomic Sciences & Veterinary Medicine Bucharest - Usamv, 2025) Mesci, MuammerAkcakoca is a district in T & uuml;rkiye known for its unspoiled natural landscapes, historical landmarks, and rich cultural heritage. For the past 50 years, it has played an important role in tourism and is strategically located at an equal distance from two of the country's largest cities. Alternative tourism is new opportunity for Akcakoca district besides mass tourism. The goal of this research study is to assess Akcakoca region potential to develop rural tourism. To achieve this, the perspectives of local residents engaged in rural tourism were examined. A quantitative research approach was adopted, and data were collected through face-to-face surveys. Using a convenience sampling method, responses from 175 participants were analyzed. The findings indicate that in order to enhance rural tourism in Ak & ccedil;akoca, greater emphasis should be placed on investment, promotion, and infrastructure. Expanding tourism activities throughout all four seasons, increasing local awareness, and distributing tourism revenues more evenly are seen as key steps toward sustainable regional development. Furthermore, collaboration among local authorities, tourism enterprises, and the community is essential for designing effective strategies. In this regard, encouraging greater participation of women and young people in tourism initiatives is expected to strengthen the positive impact of rural tourism on the local economy.Öğe Sex Prediction From the Clavicle Using Computerized Tomography Images via Traditional and Hybrid Deep Learning Models(Wiley, 2026) Secgin, Yusuf; Cakmak, Muhammet; Senol, Deniz; Kaya, Seren; Ozturk, Oguzhan; Harmandaoglu, Oguzhan; Onbas, OmerThe aim of this study is to perform high accuracy sex prediction from clavicle images using proposed hybrid deep learning models and traditional deep learning models. The clavicle of 807 female and 805 male individuals obtained from Computed Tomography were segmented in 3D format and saved in jpeg format as superior-inferior and right-left. MobileNetV2, DenseNet201, and ResNet101 traditional deep learning models and the proposed MobileNetV2+Multilayer Perceptron (MLP) and MobileNetV2+MLP+t-distributed Stochastic Neighborhood Embedding (t-SNE) based hybrid deep learning models were trained with the training set. The training was performed both with and without right-left side discrimination. The performance of each model was evaluated and compared. The highest accuracy rate of 91% was obtained in the training with both proposed hybrid models without side discrimination. The highest success rate obtained with the proposed models was 88%. The lowest accuracy rates were achieved with ResNet101. The accuracy rate was 81% in the analysis with side discrimination and 83% in the analysis without discrimination. According to Grad-Cam, the extremitas sternalis tip contributed the most to accuracy. In this study, MobileNetV2+MLP and MobileNetV2+MLP+t-SNE provided highly accurate results in sex prediction. This approach is a potential new method that can be used in sex estimation, especially in forensic medicine, as it allows the collection of features with MobileNetV2, classification with MLP, visualization with t-SNE, and observation of errors without metric measurement, directly from the superior and inferior available images of the clavicle.
