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Öğe Water and Conflict in the Middle East(Seta Foundation, 2024) Ilkbahar, Hasan[No abstract available]Öğe Critical equimatchable graphs(Centre Discrete Mathematics & Computing, 2024) Deniz, Zakir; Ekim, TinazA graph G is equimatchable if every maximal matching of G has the same cardinality. In this paper, we investigate equimatchable graphs such that the removal of any edge creates a graph that is not equimatchable, called edge -critical equimatchable graphs (ECE-graphs). We show that apart from two simple cases, namely bipartite ECE-graphs and even cliques, all ECE-graphs are 2 -connected factor -critical. Accordingly, we give a characterization of factor -critical ECE-graphs with connectivity 2. Our result provides a partial answer to an open question posed by Levit and Mandrescu [Eur. J. Comb. 20 (2019), 261-272] on the characterization of wellcovered graphs with no shedding vertex. We also introduce equimatchable graphs such that the removal of any vertex creates a graph that is not equimatchable, called vertex -critical equimatchable graphs (VCE- graphs). To conclude, we clarify the relationship between various subclasses of equimatchable graphs (including ECE-graphs and VCE-graphs) and discuss the properties of factor -critical ECE-graphs with connectivity at least 3.Öğe Novel Tetrazole And 1,3,4-Oxadiazole Derivatives Synthesis, Molecular Docking, Adme, Potential Activator For Rabbit Muscle Pyruvate Kinase(Univ Babes-Bolyai, 2024) Kaya, Mustafa Oguzhan; Demirci, Tuna; Karipcin, Selman; Ozdemir, Oguzhan; Kaya, Yesim; Arslan, Mustafa. The activation of muscle pyruvate kinase (PK) increases the conversion of phosphoenolpyruvate (PEP) to pyruvate, which results in the production of ATP. This is critical for supplying the energy needed for muscle contraction. In this study, we synthesized 1,4-dihydropyridine/pyridine compounds bearing tetrazole and 1,3,4-oxadiazole groups by using Hantzsch method and characterized by FT-IR spectroscopy, elemental analysis, and The studies revealed that all original synthesized compounds activated PK and AC50 (half-maximal activating concentration) values of the compounds were extremely effective (1.30 mu M to 14.65 mu M).Öğe Investigation of Cytotoxic, Antimetastatic and Apoptotic Activities of Jerusalem Artichoke (Helianthus tuberosus L.) Extracts: Comparison with MCF-7 and MCF-12A Cells(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2024) Beyazyu, Fadime; Arslan, Emine; Koygun, GozdeJerusalem artichoke (Helianthus tuberosus L.) is an important medicinal plant due to its composition of several bioactive substances, high antioxidant activity, rich inulin content and produces functional food ingredients. Complementary alternative medicine therapies become more popular for cancer treatments because of higher efficiency, lower cost and minimum side effects. This study reported anti -cancer efficiency of both shell and tuber extract of Jerusalem artichoke (JA) on different breast cell lines with the purpose of discovering new alternative medicine therapies. Cytotoxic effects of JA were evaluated by XTT method by using different concentrations on different incubation times (24h, 48h and 72h). Invasion, adhesion and apoptotic studies were performed with IC50 values for 48h and 72h. JA extracts do not show cytotoxic activity on healthy human breast cell, while they induce tumoral cell death with dose and timedependent manner. The most effective doses of tuber and shell extracts were 108.8 mu M and 134.2 mu M at 48h and 20 mu M ve 5 mu M at 72h, respectively. It demonstrated robust anti -metastatic activity on MCF-7 cell lines because it inhibited adhesion, and invasion, significantly. TMRE and AnnexinV/7AAD staining were used for determine to mitochondrial membrane potential and nuclear morphology, respectively The results were found consistent with each other. Overall, this paper which first in literature demonstrates the anti -cancer efficacy of the JA both tuber and shell extract which can be proposed as a potent candidate for the treatment of breast cancer.Öğe EARTHQUAKE DISASTER AND ITS' ACUTE EFFECT ON PEDIATRIC HEMATOLOGY AND ONCOLOGY.IN TURKIYE; TURKISH PEDIATRIC ONCOLOGY GROUP-TPOG QUESTIONARE STUDY(Wiley, 2023) Tacyildiz, Nurdan; Ozdemir, Sonay Incesoy; Kupeli, Begul; Cemaloglu, Mustafa; Acipayam, Can; Oncel, Kahraman; Akinel, Ayse Nur[No abstract available]Öğe Comparison of fast regression algorithms in large datasets(Academic Publication Council, 2023) Cangur, Sengul; Ankarali, HandanThe aim is to compare the performances of fast regression methods, namely dimensional reduction of correlation matrix (DRCM), nonparametric dimensional reduction of correlation matrix (N-DRCM), variance inflation factor (VIF) regression, and robust VIF (R-VIF) regression in the presence of mul-ticollinearity and outliers problems. In all simulation-scenarios, all the target variables were chosen for final models using four methods. The DRCM and N-DRCM are the methods that reach the final model in the shortest time, respectively. The time to reach the final model using R-VIF regression was approxi-mately twice shorter than that of VIF regression. In each method, as the number of variables and the level of outliers increased, the time taken to reach the final model increased. When the level of multicollinear-ity and the number of variables (p > 500) increased, the times to reach the final models using DRCM in datasets with outliers were slightly shorter than the those of N-DRCM. The largest numbers of noise variables were selected to the model using DRCM and N-DRCM, but the least number of them were selected to the model using the R-VIF regression. The RMSE values obtained using DRCM, N-DRCM and VIF regression were similar in each scenario. As a result of the real dataset, the final model selected using R-VIF regression had the highest R-2. It also had the lowest RMSE value among those obtained with other approaches excluding VIF regression. As such, the R-VIF regression method demonstrated a better performance than the others in all datasets.Öğe Cell(Rector Ciu Cyprus Int Univ, 2023) Gozen, Hacer; Edman, Timucin Bugra; Guven, Edman-Samet[No abstract available]Öğe INFLUENCE OF BONDLINE THICKNESS ON THE PERFORMANCE OF ADHESIVE JOINTS UNDER BALLISTIC PEEL IMPACT(Amer Soc Mechanical Engineers, 2023) Demir, Gizem Derya; Yildiz, Salih; Gursel, Ali; Ikikardaslar, Kerim Tuna; Delale, FeridunAs structural adhesive technology advances, adhesive joints provide attractive advantages over conventional fastening methods. Since welding, riveting, and bolting may cause nonuniform stress distribution across the joint, and in many cases cannot be used to bond dissimilar materials such as composites to metals, adhesive joining may be considered as an alternative joining method. It is well known that the geometry of adhesive joints as well as their material properties and the adhesive thickness may affect their performance. In this study, an adhesive joint consisting of an aluminum back plate and a patch bonded by an epoxy is employed to investigate the influence of the bond thickness on the performance of adhesive joints under predominantly Mode I ballistic impact. A pressure gas gun is used for the dynamic test. High speed camera (Phantom V710) was used to record specimen behavior under ballistic peel impact tests. Frame rate of the high-speed camera to capture impacts was kept at 120,000 per second. The effect of bondline thicknesses (i.e., 0.005. (0.127 mm), 0.01. (0.254 mm), 0.015. (0.381 mm) on the adhesive joint performance were investigated. The results indicate that the adhesive joint with 0.01. mm bondline thickness performs better than those with 0.005. and 0.015. adhesive thickness. In addition to the experimental work, Finite Element Analysis is carried out to determine the mechanical properties of the joints by an inverse problem-solving technique.Öğe Efficacy of Sinapic Acid Administration in a Model of PenicillinInduced Epilepsy(Wiley, 2023) Coskun, Ayca; Beyazcicek, Ersin; Beyazcicek, Ozge; Gok, Ali[No abstract available]Öğe Clonal CD4+Cytotoxic T Lymphocytosis Concomitant With POEMS Syndrome: A Co-Existence of Key Findings for Relevance in the Pathogenesis(Cig Media Group, Lp, 2023) Gultekin, Burak; Kaya, Berker; Goksoy, Yagmur; Altinkaynak, Mustafa; Onec, Birgul; Altay, Yilmaz; Yegen, Gulcin[No abstract available]Öğe Prevalence of High-Risk Human Papillomavirus Types and Their Association with Cervical Squamous Cell Carcinoma, and High- and Low-Grade Squamous Intraepithelial Lesions in Turkish Women(Iranian Scientific Society Medical Entomology, 2023) Erkinueresin, Taskin; Kartal, Esra; Ustunyurt, Emin; Demirci, Hakan; Kilitci, Asuman; Onal, BinnurBackground: This study aimed to investigate human papillomavirus (HPV) type prevalence in our region and the relationship between uterine cervical HPV types and squamous cell carcinoma (SCC)/intraepithelial lesions.Methods: HPV test results were obtained from patient file archives of the Gynecology and Obstetrics Clinic. Pathology report results were obtained from the digital records of the Pathology Laboratory and the patient file archives of the Gynecology and Obstetrics Clinic in 2018.Results: The most frequently detected was HPV16 (29.2%), followed by HPV51 (13.1%), HPV56 (11%), HPV31 (9.2%), HPV52 (8.4%), and HPV68 (8.2%). HPV16 was positive in 50% of patients diagnosed with SCC, 54.9% of patients with HSIL, 27% of patients with LSIL, and 25% of cases diagnosed as benign (P<0.001). HPV18 was positive in 25% of patients diagnosed with SCC, 11% of patients with HSIL, 4.7% of patients with LSIL, and 5.2% of cases diagnosed as benign (P=0.019).Conclusion: The most frequent hrHPV genotype was HPV16, followed by HPV51, HPV 56, and HPV 31. There is an increase in the frequency of HPV51 and HPV56. HPV51, not included in HPV vaccines and is the second most frequent, should be included in these vaccines. In addition, although the frequency of HPV18 has decreased, HSIL and SCC generation is still high together with HPV16.Öğe The effect of crude and calcined sepiolite on some physical and mechanical properties of glass fiber reinforced concrete(Serban Solacolu Foundation, 2023) Saka, Rasim Cem; Subasi, Serka; Marasli, MuhammedThe technical term GRC (glass fiber reinforced concrete) is widely used in the precast industry. This type of concrete, which is obtained by mixing cement, sand, glass fibers and some chemicals, is very durable. Compared to conventional concretes, high compressive, flexural and impact strength is the preferred choice for building facade coatings. In this paper, the usability of sepiolite as a pozzolan in glass fiber reinforced concrete and its effects on mechanical and physical properties were investigated. GRC samples were produced by adding 3% glass fiber by volume to substituted mixtures. Crude and calcined sepiolites were replaced with cement at 5%, 10%, 15% and 20% by weight. Compressive strength, flexural strength, impact strength and abrasion resistance of produced GRC samples were determined. As a result, It was observed that as sepiolite ratio increased, mechanical and physical properties of samples decreased in early and later ages, and crude sepiolite substituted samples had lower mechanical strength than the calcined sepiolite substituted samples.Öğe An investigation of the corrosion of magnesium alloys for resorbable biomedical implants(Assoc Italiana Metallurgia, 2023) Nani, L.; Cabrini, M.; Carrozza, A.; Lorenzi, S.; Gerengi, H.; Gritti, L.; Persico, T.The aim of this paper is to evaluate the mass loss rates of two magnesium and rare earth alloys, specifically WE43B and EV31A, in comparison with commercially pure magnesium. The growing interest for magnesium alloys in the field of bioabsorbable osteosynthesis devices is because they simultaneously fulfil the needs of biocompatibility and superior mechanical performance compared to biodegradable polymers. Weight loss tests were carried out for different exposure times in aerated isotonic solution (0.9% NaCl) at 37 degrees C. The results obtained showed excellent corrosion resistance of alloy WE43B compared to the other analyzed materials. Otherwise EV31A alloy exhibited numerous localized attacks, although showing lower weight loss than commercially pure magnesium. Alloy WE43B has a constant dissolution rate over the exposure time, whereas alloy EV31A and commercially pure magnesium exhibit a rate of corrosion that decreases over time due to the strong alkalinization of the solution and the deposition of a thick layer of corrosion products.Öğe Dermatoscopic Features of Early Erythema Chronicum Migrans(Croation Dermatovenerological Soc, 2023) Ozcan, Yunus; Takir, Sumeyye Gunes; Karagun, Ebru; Uyar, Belkiz[No abstract available]Öğe Fatty acid composition of stems, leaves, flowers, and seeds of some medicinal plants(Innovhub Ssi-Area Ssog, 2023) Kokten, Kagan; Mokhtarzadeh, Sam; Cacan, Erdal; Kutlu, Mehmet Ali; Ozdemir, Selim; Ucar, Ridvan; Ekmekci, MuammerMedicinal plant species are economically important and have many uses. In this research, the stem, leaves, flowers, and seeds of some medicinal plant species such as Lavandula intermedia, Satureja hortensis and Ocimum basilicum were analysed. The fatty acid compositions of these three different species were determined by gas chromatography of methyl esters of fatty acids. The stem, leaf, flower, and seed oils of L. intermedia contain 44.72%, 45.11%, 29.89% and 8.55% palmitic acid and 16.18%, 23.21%, 34.76% and 39.76% linolenic acid, respectively, as the main component fatty acids, while the stem, leaf, flower and seed oils of S. hortensis contain 23.11%, 11.76%, 13.32% and 6.26% palmitic acid and 31.70%, 51.74%, 47.97% and 43.79% linolenic acid, respectively, as main component fatty acids. On the other hand, stem, leaf, flower, and seed oils of O. basilicum contain 44.72%, 45.11%, 29.89% and 8.55% palmitic acid and linolenic acid 16.18%, 23.21%, 34.76% and 39.76%, respectively, as main component fatty acids.Öğe Morphometry of the Middle Cerebral Arteries: A Radio-Anatomical Study Based on Computed Tomography Angiography Findings(Soc Chilena Anatomia, 2023) Ciftci, Rukiye; Toy, Seyma; Ulubaba, Hilal Er; Senol, Deniz; Cinarli, FS.; Sigirci, AhmetMiddle cerebral artery (MCA), which has the largest irrigation area of the arteries that feed the brain, is an important artery whose microanatomy should be well known because of its vascular variation. In pathologies which are known to affect the cerebrovascular system such as type 2 diabetes mellitus (T2DM) and hypertension, morphometric characteristics of MCA gain importance. The aim of this study is to compare the morphometric characteristics of M1 segment of MCA in T2DM and hypertensive patients with those of healthy control group by using computed tomographic angiography (CTA). The study was carried out with retrospective morphometric analysis of CTA images of 200 individuals between 40 and 65 years of age. The individuals were grouped in four as hypertensive patients (group 1), patients with T2DM (group 2), patients with hypertension and T2DM (group 3) and healthy control group (group 4). Length and diameter measurements of M1 segment were performed and recorded by using 3D CTA images. While statistically significant difference was found between bilateral M1 segment diameters of both women and men (p<0.05), no statistically significant difference was found between segment lengths (p>0.05). As a result of the post hoc analysis performed, it was concluded that right and left M1 segment diameter of group 1, group 2 and group 3 was found to be different from group 4 in both sexes (p<0.05). We believe that this study will both be a guide in radio-anatomic assessments to be performed and also increase microanatomic level of information in the surgical treatment of the artery by showing the morphometric changes that occur in M1 segment of MCA in T2DM diseases.Öğe Morphological and Molecular Analysis of Incidental Neoplasia in Explanted Lungs with UIP/IPF: A Single Centre Experience(Elsevier Science Inc, 2023) Lunardi, F.; Verzeletti, V.; Pezzuto, F.; De Chellis, C.; Tauro, V.; Fortarezza, F.; Kilitci, A.[No abstract available]Öğe The Effect of Acute And Chronic Harmaline Administration On Penicillin Induced Epileptiform Activity In Rats(Wiley, 2023) Ozkan, Kayhan; Demir, Serif[No abstract available]Öğe Habitat-related Egg Size Differences and Hatching Success in the Spur-Winged Lapwing Vanellus spinosus (L., 1758) (Charadriiformes: Charadriidae)(Inst Zoology, Bas, 2023) Ozkan, LeylaEgg size in birds is a factor that affects their reproductive success, especially in the size and survival rates of the chicks. Until they learn to find food within a few days after hatching, precocial-type chicks need to use their own biological reserves to supply the energy they expend in walking, running, hiding from predators, etc. The spur-winged lapwing Vanellus spinosus (L., 1758) is a common lapwing species having precocial-type offspring. The species is seen as a summer visitor in Tfirkiye and Bogazkent is one of its important breeding areas in the country. In the present study, the characteristics of the eggs laid in three habitats (agricultural lands, barren lands and meadows) within this area were compared. To this purpose, the eggs were weighed and their width and length were measured. In addition, the volume and sphericity index of the eggs were calculated. We found significant differences in egg measurements between the habitats with eggs laid in meadows being larger, heavier and with greater egg volume than in the other two habitats. However, the hatching rates in the meadows were the lowest (43.8 %) in comparison with the agricultural lands (67.7 %) and barren lands (73.3 %), possible due to potentially higher predation pressure in meadows.Öğe Gender representation in children's programming on Turkish television: A public, private mass media analysis of the popular cartoon, Pepee(Inst Education Policy Studies, 2023) Hayirsever, FahriyeThis study was developed to examine the popular cartoon Pepee, which is broadcast on a private TV channel in Turkey, considering gender equality. The results are discussed by comparing them with the results of another study that scrutinizes the broadcast of the same cartoon on a Turkish public TV channel (Kalayci, 2015). The purpose of this comparison is to determine whether the messages on gender equality/inequality differ in terms of TV channels' belonging to public and private media corporations and whether the messages are similar or different. The research is designed in a descriptive model and has qualitative research characteristics due to utilizing the document review method. The documents analyzed in the study are audio-visuals, the 30 episodes of the cartoon Pepee which were broadcast on a private television channel. The themes determined by Kalayci (2015) were used in the collection and analysis of the data. Although the number of gender equality messages were reduced in Pepee's private media broadcast episodes compared to the public media, they still exist. The results show that women's and men's gender roles are considerably homogenized between private and public mass media. The differences are notable but not greatly significant. This is a solidification of the critical literature on both state and private mass media and ideological hegemony. This paper works to analyze scientifically the behavioral characteristics of the characters regarding the development of gender role modelling. It finds that regardless of media company control, consistent themes of female domesticity, and relative passivity and male vocational activity putting them at a relative distance from the nurturing components of home living.While democratic discourses are found in some episodes of the Pepee cartoon that were examined, the opposite practices are also present implicitly. Although the media are conceptually and practically categorized as private and public, the contents of broadcasts of both are shaped in line with the ideology of the state, and the continued privatization and homogenization of both social and private space. As digital and social media expand greatly, traditional mass media still hold an important place in social education. If countries advocate a democratic way of life, continued critical evaluation of the expression of mass media is still essential, concerning the process of entertainment and it's ideological, educational function.
