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Öğe Sex Prediction From the Clavicle Using Computerized Tomography Images via Traditional and Hybrid Deep Learning Models(Wiley, 2026) Secgin, Yusuf; Cakmak, Muhammet; Senol, Deniz; Kaya, Seren; Ozturk, Oguzhan; Harmandaoglu, Oguzhan; Onbas, OmerThe aim of this study is to perform high accuracy sex prediction from clavicle images using proposed hybrid deep learning models and traditional deep learning models. The clavicle of 807 female and 805 male individuals obtained from Computed Tomography were segmented in 3D format and saved in jpeg format as superior-inferior and right-left. MobileNetV2, DenseNet201, and ResNet101 traditional deep learning models and the proposed MobileNetV2+Multilayer Perceptron (MLP) and MobileNetV2+MLP+t-distributed Stochastic Neighborhood Embedding (t-SNE) based hybrid deep learning models were trained with the training set. The training was performed both with and without right-left side discrimination. The performance of each model was evaluated and compared. The highest accuracy rate of 91% was obtained in the training with both proposed hybrid models without side discrimination. The highest success rate obtained with the proposed models was 88%. The lowest accuracy rates were achieved with ResNet101. The accuracy rate was 81% in the analysis with side discrimination and 83% in the analysis without discrimination. According to Grad-Cam, the extremitas sternalis tip contributed the most to accuracy. In this study, MobileNetV2+MLP and MobileNetV2+MLP+t-SNE provided highly accurate results in sex prediction. This approach is a potential new method that can be used in sex estimation, especially in forensic medicine, as it allows the collection of features with MobileNetV2, classification with MLP, visualization with t-SNE, and observation of errors without metric measurement, directly from the superior and inferior available images of the clavicle.Öğe Metal Ion-Engineered Carbon Quantum Dots From Hazelnut Shell via Solid-State Synthesis for Efficient OLED Devices(Wiley, 2026) Cengiz, Fatmanur Uyumaz; Turksoy, Figen; Tekin, Emine; Utkan, Guldem; Cengiz, Erhan Sukru; Yumusak, Gorkem; Kahraman, Memet VezirIn this study, we report a scalable and green solid-state synthesis of nitrogen-doped carbon quantum dots (CQDs) from hazelnut shell biomass, using citric acid and urea as carbon and nitrogen sources. Controlled BaCl2 and ZnCl2 doping was applied to tailor nucleation, crystallinity, and surface chemistry. Structural analyses (FTIR, XRD, STEM, XPS, and DLS) revealed that BaCl2-assisted CQDs exhibited higher graphitization, narrower size distribution (7-13 nm), and fewer defects, while ZnCl2-assisted CQDs showed more amorphous and heteroatom-rich surfaces. Optical measurements indicated strong pi-pi* absorption (approximate to 280 nm), bright blue emission (lambda(em) 405-412 nm), and quantum yields of 63.4% (BaCl2) and 50.1% (ZnCl2), with > 95% stability after 30 days. When used as OLED emissive layers, BaCl2-CQDs achieved a luminous efficiency of 0.75 cd A(-1), nearly four times that of ZnCl2-CQDs (0.20 cd A(-1)), despite lower maximum luminance (48.9 vs. 308.1 cd m(-2)). These results highlight metal ion-assisted nucleation as an effective strategy to engineer CQD properties and enhance device performance, paving the way for sustainable, scalable OLED technologies.Öğe Electrophysiological Monitoring of Multifurcated Recurrent Laryngeal Nerve With Motor Multibranches(Wiley, 2026) Gurleyik, Emin[Abstract Not Available]Öğe 1,2,4-Triazole-Acetamide Conjugates as hEGFR Inhibitors: Synthesis, Anticancer Evaluation, and In Silico Studies(Wiley-V C H Verlag Gmbh, 2026) Bulbul, Bahadir; Kulabas, Necla; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Cakmak, Ummuhan; Tuncay, Fulya Oz; Kucukguzel, IlkayA series of novel 1,2,4-triazole-acetamide derivatives was synthesized and evaluated for anticancer and hEGFR inhibitory activity. The compounds were obtained via multistep synthesis and characterized by spectroscopic methods. Cytotoxicity was tested against PC-3, MCF-7, A549, and K562 cell lines. Compounds 18, 19, and especially 24 showed notable antiproliferative effects, with compound 24 exhibiting higher selectivity and potency than gefitinib. It also induced apoptosis and inhibited migration in A549 and PC-3 cells, while selectively promoting invasion in PC-3, suggesting EMT-related behavior. In vitro kinase assays revealed compound 20 as the most potent hEGFR inhibitor (IC50 = 43.8 +/- 1.3 nM). Molecular docking and 200 ns molecular dynamics simulations confirmed its stable interaction with EGFR, particularly involving Cys797. These findings highlight compounds 20 and 24 as promising candidates for further development as EGFR-targeted anticancer agents.Öğe Epilepsy knowledge as an independent predictor of attitudes toward epilepsy among health services students: A cross-sectional study(Wiley, 2026) Kilic, Umit; Bayram, SerapBackground Epilepsy is one of the most common neurological disorders worldwide and is frequently accompanied by stigma and misconceptions. Negative attitudes toward individuals with epilepsy may adversely affect social integration, access to healthcare, and quality of life. Healthcare students represent future professionals whose knowledge and attitudes may influence both patient care and stigma reduction.Objective This study aimed to examine the relationship between epilepsy-related knowledge and attitudes among health services vocational school students and to determine whether knowledge independently predicts attitudes toward epilepsy.Methods This cross-sectional study was conducted among students enrolled in a health services vocational school. Data were collected using a structured questionnaire including sociodemographic characteristics, an Epilepsy Knowledge Scale, and an Attitude Toward Epilepsy Scale. Multivariate regression analyses were performed to identify independent predictors of attitudes while adjusting for demographic and experiential variables.Results Higher levels of epilepsy-related knowledge were significantly associated with more positive attitudes toward epilepsy. In multivariate analysis, knowledge score remained the only significant independent predictor of attitudes, whereas demographic and experiential factors were not independently associated with attitudes toward epilepsy.Conclusion Epilepsy-related knowledge appears to play a key role in shaping attitudes among health services vocational school students. Educational strategies aimed at improving epilepsy knowledge may contribute to reducing stigma and promoting more supportive attitudes among future healthcare professionals.Öğe Evaluation of Knowledge About Human Papillomavirus and Vaccination Among Women Screened for Cervical Cancer(Wiley, 2026) Kucukceran, Hatice; Demirbas, Nur; Karaoglu, Nazan; Cihan, Fatma Goksin; Hamzaoglu, Fatma Kilic; Demir, Emine TurenBackground In Turkiye, every sexually active woman between the ages of 30 and 65 is screened for cervical cancer free of charge every five years. However, the Human papillomavirus (HPV) vaccine has not yet been included in the national vaccination calendar. Aims This study aimed to determine the knowledge of women screened for cervical cancer about HPV and the HPV vaccine. Methods In this cross-sectional study, a questionnaire consisting of a demographic information form, HPV vaccination status, and the HPV Knowledge Scale was administered to women aged 30-65. The scale has three subscales: 'General HPV Knowledge', 'HPV Test Knowledge', and 'HPV Vaccine Knowledge'. Data analysis included the Chi-square test for categorical data and the Mann-Whitney U test for numerical data. Results Of the women involved in the study, 482 in number, 55.6% of them (n = 268) had been previously screened for cervical cancer. Only 1.9% (n = 9) had the HPV vaccine, and insufficient information was the most frequent reason for not being vaccinated (73.4%; n = 354). Among those who had previously been screened for HPV, 83.6% (n = 224) reported receiving information about HPV, and 67.5% (n = 181) reported receiving information about the HPV vaccine. General HPV and HPV test knowledge subscale scores were higher among those who had been screened (p < 0.001), but there was no difference in HPV vaccine knowledge subscale scores between those who had been screened and those who had not (p = 0.977). Conclusion Cervical cancer screening did not appear to have affected the level of knowledge regarding HPV vaccination. Subsequent studies can investigate the impact of providing standard HPV vaccine information during screening on vaccination rates.Öğe Predicting the potential geographic distribution of Fagus orientalis Lipsky under climate change using an ensemble model approach in Türkiye(Springer Heidelberg, 2025) Koc, IsmailOriental beech (Fagus orientalis Lipsky) is an ecologically and economically significant species, covering 8.5% of T & uuml;rkiye's total forest area. However, climate change threatens its distribution due to increasing temperatures and decreasing precipitation. This study integrates geospatial informatics and ensemble modeling (EM) to predict the potential geographic distribution (PGD) of F. orientalis under future climate scenarios using Biomod2 within the ShinyBIOMOD framework. An EM model has been developed from six models [Generalized Boosting Model (GBM), Generalized Linear Model (GLM), Multivariate Adaptive Regression Splines (MARS), Generalized Additive Model (GAM), Artificial Neural Networks (ANN), and Maximum Entropy (MaxEnt)] using 76 validated occurrence records and 19 environmental predictors. Model validation achieved high predictive accuracy (AUC = 0.96, TSS = 0.85). Spatial projections for SSP2-45 and SSP5-85 scenarios indicate significant shifts in PGD. Notably, high-suitability habitats will decline under SSP2-45 but expand under SSP5-85. Bio2 [Mean Diurnal Range (mean of monthly (maximum temperature - minimum temperature))] and Bio4 [Seasonal temperature fluctuation (temperature seasonality (standard deviation x 100))] emerged as the dominant drivers of distribution changes. Based on geospatial analyses, F. orientalis is expected to migrate to higher altitudes in the Black Sea region and expand into southern and inner T & uuml;rkiye. This shift reflects a broader trend of temperate forest adaptation to climate change. This study underscores the power of ensemble modeling for ecological forecasting and conservation planning, demonstrating the value of computational tools in assessing climate-driven species distribution changes. The findings contribute to predictive modeling for biodiversity conservation and ecosystem management.Öğe Is Saturation Biopsy Still a Viable Alternative to Fusion Biopsy in the Era of Multiparametric MRI? A Comparative Analysis in Patients With Prior Negative Biopsy(Wiley, 2026) Taskiran, Arda Taskin; Senoglu, YusufBackground: We aimed to compare the diagnostic accuracy of transrectal ultrasound (TRUS)-guided saturation biopsy (SB) and multiparametric MRI (mpMRI)-TRUS fusion-guided combined biopsy (CB) in patients with prior negative prostate biopsies. Methods: We retrospectively analyzed data from 160 patients who underwent transrectal prostate biopsy between January 2014 and March 2021. All had at least one prior negative biopsy. 80 patients underwent SB with a 20-core TRUS-guided approach. The remaining 80 patients, with mpMRI-detected PIRADS >= 3 lesions, underwent CB including 12-core systematic plus 2-4 targeted cores per lesion. Prostate cancer and clinically significant prostate cancer (csPCa) detection rates, and clinical parameters were compared between groups. Results: The groups had no statistically significant differences in baseline characteristics. The PCa detection rate was 20% in the CB group and 16.3% in the SB group (p = 0.682). csPCa detection rates were also similar: 11.3% in the CB cohort and 7.5% in the SB cohort (p = 0.589). Notably, the CB subgroup with PI-RADS >= 4 lesions had a significantly higher csPCa detection rate (28.6%) than SB group (7.5%) (p = 0.016). Patients diagnosed with PCa had significantly lower free PSA and free/total PSA ratios (p < 0.05). Complication rates were low and similar in both groups. Conclusions: CB demonstrates the highest diagnostic yield for detecting csPCa, particularly in patients with PI-RADS >= 4 lesions. However, in resource-limited settings lacking mpMRI, systematic saturation biopsy remains a viable, safe, and effective alternative. PSA derivatives may serve as complementary tools to refine biopsy decisions.Öğe Redox-Mediated Phosphorus Adsorption on Manganese Oxysulfide in Aqueous Solutions(Wiley, 2025) Ulgudur, Nilufer; Gultekin, Zeyneb senaAlthough phosphorus is essential for living organisms, its release into the environment requires strict control due to pollution concerns. This study investigated the potential of phosphorus removal from water by manganese oxysulfide (MnOxSy) synthesized using a one-pot chemical precipitation method. Phosphorus adsorption capacity obtained as 42.1 mg/g (initial phosphorus concentration, 105.0 mg/L; pH 4.95; adsorbent dosage, 1 g/L). The adsorption mechanism included phosphorus speciation, MnOxSy protonation, electrostatic attraction, and redox adsorption. Phosphorus was removed by chemisorption as indicated by pseudo-second order kinetics (R 2, 0.9963-0.9999) forming monolayer coverage on MnOxSy (Langmuir, R 2 0.9775). Negative Delta H degrees and Delta G degrees values revealed that the adsorption was exothermic and spontaneous, confirming energetic favorability at ambient temperature. The phosphorus removal efficiencies in real liquid digestate (86.7% +/- 0.7%), simulated nutrient-rich wastewater (87.9% +/- 0.1%), and only phosphorus added solution (93.1% +/- 1.8%) were also comparable. These results indicated that MnOxSy is a promising adsorbent for the treatment of phosphorus from aqueous environment.Öğe Outcomes of Inverted Tympanomeatal Flap Elevation for Large Anterior Tympanic Membrane Perforations in Narrow External Auditory Canals(Wiley, 2026) Belada, AbdullahBackground and Objective Anterior tympanic membrane perforations-particularly in patients with a narrow external auditory canal-remain technically challenging due to limited visualization and inadequate anterior support. The inverted tympanomeatal flap technique has been proposed to address these issues, but evidence is limited. This study aimed to evaluate its anatomical and functional outcomes in large anterior perforations treated with endoscopic transcanal tympanoplasty. Methods This retrospective single-surgeon study included 70 patients with large anterior perforations and >= 20% anterior quadrant non-visualization. All underwent standardized audiometry and at least 6 months of follow-up. Outcomes were graft success, complications, and hearing improvement. Analyses included audiometric comparisons, logistic regression, and ROC curves to identify predictors of graft failure. Results The graft success rate was 95.7% (67/70). Mean ABG improved from 23.44 +/- 10.95 dB preoperatively to 13.52 +/- 8.86 dB postoperatively (p < 0.001), with a mean hearing gain of 9.91 +/- 8.61 dB (Cohen's d = 1.00). Larger perforation size (p = 0.046) and severe external auditory canal narrowing (p = 0.041) independently predicted graft failure. ROC analysis identified > 72% perforation size (AUC = 0.78) and > 40% canal narrowing (AUC = 0.71) as risk thresholds. No cases of chorda tympani injury, canal trauma, or iatrogenic cholesteatoma occurred. Conclusion In conclusion, inverted tympanomeatal flap elevation showed favorable graft success and hearing improvement in challenging anterior perforations with narrow canals. However, due to the retrospective single-surgeon design and absence of a control group, these results should be interpreted cautiously. Larger prospective studies are needed to validate its effectiveness.Öğe Level of Personality Functioning in Turkish Clinical and Community Samples: Validation of the LPFS-SR-TR and Its Associations With Axis I Disorders(Wiley, 2026) Ozcan, Begum Yaman; Cangur, Sengul; Kara, Neslihan; Konuk, NumanThis study examines the validity and reliability of the Turkish version of the Level of Personality Functioning Scale-Self-Report (LPFS-SR-TR) and its associations with personality disorder (PD) categories and Axis I comorbidities. The cross-sectional study included 720 participants aged 18-65. From a consecutive sample of 732 patients who presented to the outpatient psychiatry clinic, experienced psychiatrists suspected 207 of having PD. They were further diagnosed using the structured clinical interview for DSM-III-R personality disorders (SCID-II). Patients were also investigated for Axis I disorders using the SCID-5 clinical version. A community-based control group of 513 participants recruited through convenience sampling received self-assessment-based SCID-II without a clinical interview. Both groups underwent the Big Five Inventory (BFI) and LPFS-SR-TR. The six-factor model provided the best statistical fit. Significant correlations between the LPFS-SR-TR and BFI indicate concurrent validity. Patients scored higher on the LPFS-SR-TR. Using a total score threshold of greater than 277.5 resulted in 93.2% sensitivity and 83.0% specificity (AUC = 0.94) for identifying PDs, indicating discriminant validity. Serial logistic models suggested incremental validity. The scale demonstrated strong internal consistency (Cronbach's alpha = 0.96) and test-retest reliability (ICC = 0.86). The LPFS-SR-TR is valid and reliable for assessing the presence and severity of PDs. The hypothesized one-dimensional factor structure may be supported given its ability to distinguish PDs from a community sample. Axis I comorbidities are common and diverse without any discernible pattern.Öğe Forensic age estimation at the 15-and 18-year thresholds using MRI of the wrist: application of the Vieth staging method(Springer, 2026) Alatas, Ozkan; Binici, Ridvan; Sari, Onur; Gurses, Murat Serdar; Has, Busra; Belet, UmitObjectives The objective of this study was to assess distal radial epiphyseal fusion on MRI based on the Vieth staging method and to evaluate the relevance of the obtained findings for determining legal majority in forensic age estimation. Methods Wrist images obtained via a 1.5 T MRI scanner were retrospctively evaluated by two independent observers in a study population of 516 cases (252 females, 264 males) aged 10-28 years, following the application of exclusion criteria. MR images were independently evaluated by two experienced radiologists, with intraobserver agreement assessed through repeat evaluation after one month and consensus assessment performed jointly by both observers. Intra- and interobserver agreement rates were evaluated using Cohen's kappa and linear weighted kappa statistics. Descriptive statistics, including minimum, maximum, mean +/- standard deviation, 95% confidence interval, and median, were defined for age distribution. Sex-specific age differences within each stage were analyzed using either the Student's t-test or the Mann-Whitney U test. Results Descriptive age statistics were evaluated separately for females and males. No significant sex-related age difference was observed at stage 2, whereas males were significantly older than females at all subsequent stages. Inter- and intraobserver agreement assessment was very good, with high agreement levels observed for both analyses. Conlusion The findings indicate that the Vieth staging method applied to wrist MRI may be applicable for forensic age estimation at the 15- and 18-year legal thresholds in both sexes. However, further validation in diverse populations using balanced age groups and experienced observers is required.Öğe Diagnostic value of postoperative magnetic resonance imaging in predicting clinical outcomes after meniscal repair: A retrospective cohort study(Springer, 2026) Bulum, Yunus Emre; Cicek, Necati; Karatas, Muhammed Enes; Dalaslan, Rasit Emin; Poyanli, Oguz SukruBackground Magnetic resonance imaging (MRI) is widely used to evaluate meniscal healing after surgical repair; however, the extent to which postoperative MRI findings reflect clinically meaningful recovery remains uncertain. This study aimed to examine the relationship between MRI-based healing appearance and patient-reported functional outcomes after meniscal repair. Methods This retrospective observational study included adult patients who underwent arthroscopic meniscal repair between January 2018 and December 2024 at a tertiary care centre. Patients with at least 12 months of follow-up, available postoperative MRI, and complete clinical outcome data were included. Postoperative MRI was obtained at a mean of 18.6 +/- 7.4 months after surgery (range: 12-36 months). Meniscal healing on MRI was classified as complete healing, partial healing, or failed healing/retear. Clinical outcomes were assessed using the International Knee Documentation Committee (IKDC), Lysholm, and Tegner scores. Clinical success was defined as IKDC >= 80 and Lysholm >= 85. The association between MRI healing status and clinical outcomes was evaluated using group comparisons and correlation analyses. Results A total of 240 patients (mean age 27.4 +/- 6.8 years; 71.7% male) were analyzed. MRI demonstrated complete healing in 40.8% of patients, partial healing in 31.7%, and failed healing or retear in 27.5%. Mean IKDC, Lysholm, and Tegner scores differed significantly across MRI groups (all p <= 0.002), with lower scores observed in patients with MRI-defined failure. However, 63.6% of patients classified as having failed healing on MRI met the criteria for clinical success. MRI healing status showed moderate correlations with IKDC (r = 0.42), Lysholm (r = 0.39), and Tegner (r = 0.31) scores (all p < 0.001). The MRI-IKDC correlation was higher in patients who underwent concomitant anterior cruciate ligament reconstruction than in those who underwent isolated meniscal repair. Conclusions Postoperative MRI appearance after meniscal repair is associated with patient-reported and functional outcomes, but the strength of this relationship is limited. MRI-defined structural abnormalities may persist despite satisfactory clinical recovery, indicating that MRI has restricted specificity for identifying clinically meaningful failure. These findings suggest that MRI should be interpreted in conjunction with clinical assessment rather than used as a standalone indicator of postoperative success.Öğe Persistent extensor strength deficit despite acceptable clinical outcomes after surgical treatment of patella fractures: a mid- to long-term follow-up study(Springer, 2026) Dalaslan, Rasit Emin; Yucel, Mucahid Osman; Saglam, Sonmez; Arican, Mehmet; Karaduman, Zekeriya Okan; Sav, IsmailIntroduction To evaluate mid-to long-term clinical outcomes together with objective isokinetic measurements of knee flexor and extensor muscle strength in patients who underwent surgical treatment for AO/OTA type C patella fractures, and to investigate the relationship between fracture severity, clinical scores, and strength deficits. We hypothesized that significant quadriceps strength deficits would persist despite acceptable clinical outcomes and that these deficits would be associated with worse pain and functional scores. Materials and methods This retrospective cohort study included 58 patients treated surgically for patella fractures between 2015 and 2024, with a median follow-up duration of 60 months (IQR: 32-94; range: 13.1-132.0 months). The primary outcome was extensor muscle strength deficit measured by isokinetic dynamometry. Secondary outcomes included flexor strength deficit, Lysholm score, visual analog scale (VAS), and knee range of motion. Isokinetic dynamometry at 60 degrees/s was used to measure concentric flexor and extensor peak torque values, and strength deficits were calculated by comparison with the contralateral limb. Outcomes were compared among fracture subtypes (C1, C2, C3), and correlations between strength deficits and clinical scores were analyzed. Non-parametric tests (Kruskal-Wallis) and partial correlation analysis (Pearson, adjusted for age) were used for statistical analysis. Results At final follow-up, patients demonstrated generally acceptable clinical outcomes (mean Lysholm: 80.12 +/- 16.88; mean VAS: 2.19 +/- 1.79) with minimal extension deficits. However, the primary outcome, extensor muscle strength deficit, remained substantial a mean extensor strength deficit of 36.31 +/- 17.27%, and 84.5% of patients exhibited marked extensor asymmetry (>= 20%). Flexor strength deficits were less pronounced (19.09 +/- 10.75%) but remained clinically relevant. No statistically significant differences were detected in clinical scores, range of motion, or strength deficits were observed among fracture subtypes (p > 0.05). Greater extensor and flexor strength deficits were significantly associated with higher VAS scores and lower Lysholm scores (all p < 0.05). Revision surgery was required in 12% of patients, and implant removal in 38%, indicating a considerable secondary surgical burden. Conclusions Despite satisfactory clinical scores and radiographic healing, substantial and persistent quadriceps weakness appears to be common after surgically treated patella fractures. Objective strength deficits are strongly associated with pain and functional outcomes and may not be fully captured by conventional clinical assessments. Long-term management should therefore incorporate objective muscle strength evaluation and targeted rehabilitation strategies to address persistent extensor weakness.Öğe Morphometric and topographic analysis of the flexor carpi radialis tendon, its tunnel, and the median nerve: an MRI-based anatomical guide for wrist interventions(Springer France, 2026) Kaya, Seren; Secgin, Yusuf; Senol, Deniz; Harmandaoglu, Oguzhan; Ozturk, Oguzhan; Onbas, OmerPurpose This study aimed to evaluate the morphometric features of the flexor carpi radialis(FCR) tendon and its tunnel, and their topographical relationships, using wrist magnetic resonance(MR) images. Methods Axial MR images of 190 individuals aged 18-45 years (95 women and 95 men) were retrospectively analysed. Measurements included distances of the FCR tendon to the radial artery (RA), ulnar artery (UA), median nerve (MN), and scaphoid; trapezium tubercle dimensions; FCR tunnel angle, area, and retinacular thicknesses; retinaculum bending ratio; FCR tendon-to-MN area ratio; and FCR tunnel-to-carpal tunnel ratios. The topographic relationship between the FCR tendon and MN was assessed at the levels of the FCR tunnel and pisiform. Positions of the MN and other tendons in the carpal tunnel were also recorded. Results The mean FCR tunnel area was 8990 +/- 2238 mm(2) in males and 7979 +/- 1792 mm(2) in females. Significant sex-related differences were identified in the distances of the FCR to the RA, UA, and MN, as well as in tunnel areas (p < 0.05). Right-left comparisons revealed significant differences in the distances of the FCR to the scaphoid, UA, and MN, in the FCR tunnel area, and in retinacular thickness above and below the tunnel (p < 0.05). Variations were observed in the structures between the FCR tendon and MN, and in MN positioning relative to other tendons. Conclusion The findings may provide an anatomical guide to how FCR-region variations influence invasive procedures, particularly in conditions such as carpal tunnel syndrome and FCR tendinopathy, considering sex and laterality.Öğe Clinical utility of the Oakland score in rectal bleeding: Implications for admission decisions and cost efficiency(Springer, 2026) Cetin, Mehmet Fuat; Gonullu, Mehmet Emin; Yekenkurul, Erman; Gursoy, FatihBackground Rectal bleeding is a frequent cause of emergency admissions, yet objective criteria for hospitalization remain limited. The Oakland Score was developed to identify low-risk patients suitable for outpatient management. Methods This retrospective single-center study analyzed 346 patients presenting with rectal bleeding between 2015 and 2025. Patients were categorized as low-risk (Oakland <= 8, n = 142) or high-risk (Oakland >= 8, n = 204). Clinical parameters, transfusion, tranexamic acid (TXA) use, and total hospital costs were compared. Results High-risk patients were older (64.2 +/- 14.2 vs 52.4 +/- 14.1 years, p < 0.001), had lower hemoglobin (10.6 +/- 2.2 vs 12.6 +/- 1.9 g/dL, p < 0.001), lower systolic pressure (116.1 +/- 17.0 vs 124.3 +/- 15.2 mmHg, p < 0.001), and higher heart rate (92.5 +/- 14.1 vs 83.2 +/- 11.6 bpm, p < 0.001). Hospital admission (91.2% vs 40.8%), transfusion (35.3% vs 5.6%), and TXA use (73.5% vs 28.2%) were significantly greater in high-risk patients (all p < 0.001). The Oakland Score correlated positively with total cost (r = 0.55, p < 0.001) and length of stay (r = 0.52, p < 0.001). ROC analysis showed excellent discrimination for hospital admission (AUC = 0.86, p < 0.001). Conclusion The Oakland Score reliably predicts both clinical severity and healthcare burden in patients presenting with rectal bleeding. Integrating this simple and objective tool into emergency department protocols can help physicians identify low-risk patients who may be safely discharged, thereby reducing unnecessary hospitalizations, optimizing resource use, and improving overall cost-effectiveness of care.Öğe Hyperbaric oxygen therapy attenuates urethral stricture formation after urethral injury: an experimental rabbit study (vol 44, 220, 2026)(Springer, 2026) Danis, Hasan; Yuksel, Alpaslan; Baba, Dursun; Senoglu, Yusuf; Taskiran, Arda Taskin; Basaran, Ekrem; Kantarcloelu, Sinem[Abstract Not Available]Öğe Hyperbaric oxygen therapy attenuates urethral stricture formation after urethral injury: an experimental rabbit study(Springer, 2026) Danis, Hasan; Yuksel, Alpaslan; Baba, Dursun; Senoglu, Yusuf; Taskiran, Arda Taskin; Basaran, Ekrem; Tekin, AliPurpose Urethral stricture (US) is a frequent and challenging urological entity characterized by spongiofibrosis and luminal narrowing, often leading to recurrent infections, urinary retention, and upper tract deterioration. Despite various endoscopic and open surgical options, high recurrence rates remain a major problem, and there is no established medical therapy to prevent stricture formation. To investigate the protective effect of hyperbaric oxygen (HBO) therapy on fibrosis and stricture formation in an experimental urethral injury model in rabbits using objective endoscopic, radiologic, and histopathologic parameters. Methods Twenty-eight male New Zealand rabbits were randomized into three groups: sham (n = 8), urethral injury without treatment (control, n = 10), and urethral injury plus HBO (HBO, n = 10). Among the 20 rabbits with urethral injury, allocation to the untreated control group (Group 2) and the HBO treatment group (Group 3) was performed in a 1:1 ratio using a computer-generated randomization list. Standardized circumferential electrocoagulation was applied to the bulbar urethra in the control and HBO groups. HBO was administered at 2 ATA, 90 min/day for 21 consecutive days starting on the day of injury. On day 28, all animals underwent urethroscopy and retrograde urethrography; urethral specimens were then harvested for histopathological evaluation. Fibrosis was graded (0-3) using Masson trichrome staining. Results Normal urethral diameters were similar among the groups (p = 0.604). Median stricture diameter was significantly lower in the untreated control group compared with the HBO and sham groups (2.15 mm vs. 8.05 mm and normal segment, respectively; p < 0.001). Median percentage urethral narrowing was 78.52% in the control group and 23.51% in the HBO group (p < 0.001). Fibrosis scores were significantly higher in the control group than in the HBO and sham groups (p < 0.001). Conclusion HBO therapy significantly attenuated fibrosis and urethral narrowing in this experimental urethral injury model. These findings suggest that HBO may represent a promising adjuvant strategy to prevent US formation after urethral trauma, warranting further clinical investigation.Öğe Factors predicting the severity of gastrointestinal involvement in children with IgA vasculitis? A Turkish multicenter cohort study(Springer, 2026) Belder, Nuran; Acun, Busra; Ozturk, Didem; Kaya Yildirim, Naile; Oksel, Betul; Atamyildiz Ucar, Sila; Bakkaloglu, Sevcan A.Gastrointestinal (GI) involvement of IgA vasculitis (IgAV) has various clinical presentations from isolated abdominal pain to severe gastrointestinal bleeding. The aim of this study is to determine the incidence of GI involvement in children with IgAV and identify the predictors of severe GI involvement. Medical records of IgAV patients with GI involvement from 30 centers in T & uuml;rkiye between 2014 and 2024 were retrospectively reviewed. Patients were classified into two groups according to the severity of GI presentations: Group 1 consisted of mild GI involvement, while Group 2 had severe GI involvement. Severe GI involvement was observed in 476 (42%) out of 1131 patients. A significant postpandemic (after March 2020) increase in GI involvement was observed (p < 0.001). Abdominal pain as an initial symptom, vomiting, purpuric rash on upper extremities and trunk, and kidney involvement were more frequent in Group 2 than in Group 1 (all p < 0.01). Leukocytosis, neutrophilia, thrombocytosis, increased C-reactive protein (CRP) level and neutrophil-to-lymphocyte ratio (NLR), and decreased serum total protein and albumin levels were detected more frequently in Group 2 (all p < 0.01). In multivariate regression analysis, thrombocytosis, elevated NLR and CRP, hypoalbuminemia, abdominal pain preceding rash, vomiting, and upper extremity rash were associated with severe GI involvement (all p < 0.05). ROC analyses identified the following optimal cut-off values for predicting severe GI involvement: WBC > 12.90 10<^>3/& micro;L, ANS > 7.81 10(3)/& micro;L, NLR > 3.09, PLT > 404 103/& micro;L, CRP > 20 mg/L, plasma albumin <= 4 g/dL. Conclusion: Abdominal pain preceding rash, purpuric rash on upper extremities, vomiting, thrombocytosis, hypoalbuminemia, increased NLR, and high CRP may predict severe GI involvement in children with IgAV. What is Known: center dot Gastrointestinal (GI) manifestations of pediatric Immunglobulin A vascuitis (IgAV) vary from isolated abdominal pain to severe GI bleeding and complications like intussusception. center dot Older age at disease onset, genital involvement, and widespread persistent rash may predict GI involvement inIgAV. What is New: center dot The incidence of IgAV with severe GI involvement has increased in recent years. center dot Abdominal pain preceding the purpuric rash and purpuric rash involving the trunk and upper extremities mayserve as clinical predictors of severe GI involvement in children with IgAV.Öğe Evaluation of antibacterial efficacy of laser-assisted and passive ultrasonic irrigation methods in disinfection of post space and effects on bond strength of glass fiber posts to radicular dentin(Springer London Ltd, 2025) Dogan Cankaya, Tulin; Ugur Aydin, Zeliha; Kalyoncuoglu, Ulku Tugba; Erdonmez, DemetThe aim of this study was to evaluate the antibacterial efficacy of various irrigation activation methods and their effects on the push-out bond strength (PBS) of glass fiber posts (GFP) to radicular dentin in teeth with post spaces infected with E. faecalis. Sixty human mandibular premolar teeth were decoronized. All root canals were shaped using a similar protocol and sterilized in an autoclave. Sterilization was confirmed in 10 randomly selected samples. 50 root canals were obturated. Post spaces were prepared in all samples, and root canals were contaminated with E. faecalis and incubated for 4 weeks. Bacterial growth was confirmed in 10 randomly selected samples. Samples were randomly divided into four groups according to irrigation activation methods (n = 10): Standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), photon-induced photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS). CFU levels were recorded before and after disinfection by taking samples from the root canals with paper points. GFPs were cemented with self-adhesive resin cement. 2 mm thick sections were taken from the apical, middle, and coronal parts of GFPs, and a push-out test was performed with a universal testing machine. Failure modes were examined under a stereomicroscope (40x). Data were analyzed statistically. None of the irrigation methods tested achieved complete bacterial elimination. However, PIPS and SWEEPS achieved significantly greater bacterial reduction than SNI (Delta CFU [S1-S2], mean: PIPS 0.097; SWEEPS 0.090; SNI 0.045; P < .05). No significant differences were observed in PBS among groups (P > .05); values were generally higher coronally than apically (e.g., SNI 79.1 +/- 50.1 vs. 34.1 +/- 26.7 MPa), regardless of irrigation method. Adhesive fractures were dominant in all sections in SWEEPS, cohesive fractures were dominant in SNI, and mixed fractures were dominant in PUI. PIPS and SWEEPS are more effective than SNI in reducing bacterial load in the post space; however, this superiority is not reflected in bond strength. Irrigation activation method may affect the dentin surface and fracture type but does not make a decisive difference on PBS.
