Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions?

Basit Öğe Kaydı
dc.contributor.authorCömert, Mustafa
dc.contributor.authorKarakaya, Kemal
dc.contributor.authorBarut, Figen
dc.contributor.authorÇakmak, Güldeniz Karadeniz
dc.contributor.authorUçan, Hamdi Bülent
dc.contributor.authorGültekin, Fatma Ayça
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Gultekin, Fatma Ayca/0000-0002-4148-5871; Cakmak, Guldeniz Karadeniz/0000-0001-5802-4441; Emre, Ali Ugur/0000-0002-1136-0517; Karakaya, Kemal/0000-0002-6742-9923en_US
dc.descriptionWOS: 000281963300001en_US
dc.descriptionPubMed: 21038113en_US
dc.description.abstractBACKGROUND The aim of this study was to investigate whether intraabdominal Ankaferd Blood Stopper (ABS) causes increased intraabdominal adhesion formation and to determine any side effects of ABS in vivo. METHODS The present experimental study was designed to examine the effects of Ankaferd solution on peritoneal adhesion formation in a rat model of cecal abrasion. Intraperitoneal adhesions were assessed macroscopically and histopathologically on the 10th postoperative day. The possible adverse affects of ABS on liver and lung tissues were analyzed histopathologically, and blood chemistry was also evaluated. RESULTS Our study revealed that ABS reduced intraperitoneal adhesion formation in an experimental rat model. The blood chemistry was not disturbed due to ABS administration. Intraperitoneal administration of ABS led to some minor changes in the lungs and serosal surfaces of the intestines, with minor architectural changes in the liver that were not considered as toxic. Further studies with various application doses and routes with more detailed cellular analysis are thus warranted to clarify the possible pleiotropic and adverse effects of this new agent away from hemostasis. CONCLUSION There was less intraperitoneal adhesion formation in the ABS group than in the control group and saline group. Intraperitoneal administration of ABS has no toxic effects on blood chemistry or the lungs, kidneys and the liver, but it has some minor adverse effects.en_US
dc.identifier.endpage389en_US
dc.identifier.issn1306-696X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5612
dc.identifier.volume16en_US
dc.identifier.wosWOS:000281963300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjecthemostasisen_US
dc.subjectraten_US
dc.subjectside effecten_US
dc.titleDoes intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5612.pdf
Boyut:
1.48 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu