Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions?
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Assoc Trauma Emergency Surgery
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND The aim of this study was to investigate whether intraabdominal Ankaferd Blood Stopper (ABS) causes increased intraabdominal adhesion formation and to determine any side effects of ABS in vivo. METHODS The present experimental study was designed to examine the effects of Ankaferd solution on peritoneal adhesion formation in a rat model of cecal abrasion. Intraperitoneal adhesions were assessed macroscopically and histopathologically on the 10th postoperative day. The possible adverse affects of ABS on liver and lung tissues were analyzed histopathologically, and blood chemistry was also evaluated. RESULTS Our study revealed that ABS reduced intraperitoneal adhesion formation in an experimental rat model. The blood chemistry was not disturbed due to ABS administration. Intraperitoneal administration of ABS led to some minor changes in the lungs and serosal surfaces of the intestines, with minor architectural changes in the liver that were not considered as toxic. Further studies with various application doses and routes with more detailed cellular analysis are thus warranted to clarify the possible pleiotropic and adverse effects of this new agent away from hemostasis. CONCLUSION There was less intraperitoneal adhesion formation in the ABS group than in the control group and saline group. Intraperitoneal administration of ABS has no toxic effects on blood chemistry or the lungs, kidneys and the liver, but it has some minor adverse effects.
Açıklama
Ankarali, Handan Camdeviren/0000-0002-3613-0523; Gultekin, Fatma Ayca/0000-0002-4148-5871; Cakmak, Guldeniz Karadeniz/0000-0001-5802-4441; Emre, Ali Ugur/0000-0002-1136-0517; Karakaya, Kemal/0000-0002-6742-9923
WOS: 000281963300001
PubMed: 21038113
WOS: 000281963300001
PubMed: 21038113
Anahtar Kelimeler
Adhesion, Ankaferd Blood Stopper, hemostasis, rat, side effect
Kaynak
Ulusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
16
Sayı
5
