The effect of melatonin on antifungal susceptibility in planktonic and biofilm forms of Candida strains isolated from clinical samples

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dc.contributor.authorKılınçel, Özge
dc.contributor.authorÇalışkan, Emel
dc.contributor.authorŞahin, İdris
dc.contributor.authorÖztürk, Cihadiye Elif
dc.contributor.authorKılıç, Nida
dc.contributor.authorÖksüz, Şükrü
dc.date.accessioned2020-04-30T23:33:02Z
dc.date.available2020-04-30T23:33:02Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKilincel, Ozge/0000-0003-1872-6670en_US
dc.descriptionWOS: 000460630700006en_US
dc.descriptionPubMed: 29390164en_US
dc.description.abstractIn recent years, the significant increase in the isolation ofantifungal resistantCandidaspecies in presence of biofilm, have made it necessary to develop alternative agents for the treatment of these infections. In this study, the effect of antifungal susceptibility of melatonin were investigated in planktonic and biofilm forms of Candida strains isolated from theclinical samplessent to our laboratory. Biofilm formation was determined by modified microplate method. In order to determine antifungal susceptibility in biofilm-forming strains, MIC was determined by broth microdilution method in planktonic form, and MBEC values by Calgary biofilm method in biofilm form. Susceptibility tests were repeated in the presence of melatonin. Antifungal susceptibility tests repeated with antifungals combined with melatonin showed a decrease in both MIC and MBEC values;melatonin was found to be more effective especially in planktonic forms. While the most effective combination was achieved with fluconazole in the planktonic form, no statistically significant difference was found between the combinations in biofilm form. As a result, melatonin was thought to be a new alternative in the treatment of Candida infections.en_US
dc.description.sponsorshipDuzce University Scientific Research Projects CommissionDuzce University [2015.04.01.352]en_US
dc.description.sponsorshipThis work was supported by Duzce University Scientific Research Projects Commission [grant number 2015.04.01.352].en_US
dc.identifier.doi10.1093/mmy/myx157en_US
dc.identifier.endpage51en_US
dc.identifier.issn1369-3786
dc.identifier.issn1460-2709
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1093/mmy/myx157
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4880
dc.identifier.volume57en_US
dc.identifier.wosWOS:000460630700006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofMedical Mycologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantifungal susceptibilityen_US
dc.subjectbiofilmen_US
dc.subjectCandida sppen_US
dc.subjectmelatoninen_US
dc.titleThe effect of melatonin on antifungal susceptibility in planktonic and biofilm forms of Candida strains isolated from clinical samplesen_US
dc.typeArticleen_US

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