Pregnancy-Associated Plasma Protein A and High-Sensitivitive C-Reactive Protein Levels in Chronic Subdural Haematoma Patients

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dc.contributor.authorHanımoğlu, Hakan
dc.contributor.authorUlu, Mustafa Onur
dc.contributor.authorBiçeroğlu, Hüseyin
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorBalak, Naci
dc.contributor.authorUzan, Mustafa
dc.date.accessioned2020-04-30T23:21:26Z
dc.date.available2020-04-30T23:21:26Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; Ulu, Mustafa Onur/0000-0002-6256-0869; Balak, Naci/0000-0002-2395-0004en_US
dc.descriptionWOS: 000298031700005en_US
dc.description.abstractObjective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase that regulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play an active role in the pathophysiology of several conditions involving inflammatory responses. We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronic subdural haematoma (CSDH) patients and healthy controls. Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematoma fluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in the serum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2). Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantly lower than control group [9.32 ng/mL (6.57 - 17.00)] (p< 0.01) and the hsCRP levels were significantly higher in patient group [4.57 mg/L (1.56 - 12.62)] (p< 0.01). The comparison of PAPP-A values in the serum and subdural haematoma in the patient group revealed significantly very high values in the subdural fluid [204.5 ng/mL (161.1 - 261.4)] than the serum [4.15 ng/mL (2.70-12.88)] (p < 0.0001). The hsCRP values, on the other hand, were significantly lower in the subdural haematoma fluid than the serum in the patient group (p = 0.016). Conclusion: PAPP-A may have an important function in the local inflammatory events and local structural changes associated with CSDH formation and growth. The detection of high peripheral hsCRP levels in the patient group suggests that a systemic inflammatory response follows after the traumatic insult leading to CSDH formation.en_US
dc.identifier.endpage336en_US
dc.identifier.issn1302-1664
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage330en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4195
dc.identifier.volume28en_US
dc.identifier.wosWOS:000298031700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal Of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic subdural haematomaen_US
dc.subjecthsCRPen_US
dc.subjectinflammationen_US
dc.subjectPAPP-Aen_US
dc.subjectpathophysiologyen_US
dc.subjectPregnancy-associated plasma protein Aen_US
dc.titlePregnancy-Associated Plasma Protein A and High-Sensitivitive C-Reactive Protein Levels in Chronic Subdural Haematoma Patientsen_US
dc.typeArticleen_US

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