Pregnancy-Associated Plasma Protein A and High-Sensitivitive C-Reactive Protein Levels in Chronic Subdural Haematoma Patients
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal Neurological Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase that regulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play an active role in the pathophysiology of several conditions involving inflammatory responses. We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronic subdural haematoma (CSDH) patients and healthy controls. Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematoma fluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in the serum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2). Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantly lower than control group [9.32 ng/mL (6.57 - 17.00)] (p< 0.01) and the hsCRP levels were significantly higher in patient group [4.57 mg/L (1.56 - 12.62)] (p< 0.01). The comparison of PAPP-A values in the serum and subdural haematoma in the patient group revealed significantly very high values in the subdural fluid [204.5 ng/mL (161.1 - 261.4)] than the serum [4.15 ng/mL (2.70-12.88)] (p < 0.0001). The hsCRP values, on the other hand, were significantly lower in the subdural haematoma fluid than the serum in the patient group (p = 0.016). Conclusion: PAPP-A may have an important function in the local inflammatory events and local structural changes associated with CSDH formation and growth. The detection of high peripheral hsCRP levels in the patient group suggests that a systemic inflammatory response follows after the traumatic insult leading to CSDH formation.
Açıklama
Coskun, Abdurrahman/0000-0002-1273-0604; Ulu, Mustafa Onur/0000-0002-6256-0869; Balak, Naci/0000-0002-2395-0004
WOS: 000298031700005
WOS: 000298031700005
Anahtar Kelimeler
Chronic subdural haematoma, hsCRP, inflammation, PAPP-A, pathophysiology, Pregnancy-associated plasma protein A
Kaynak
Journal Of Neurological Sciences-Turkish
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
28
Sayı
3
