The effect of smoking on placental pendrin expression

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dc.contributor.authorKarataş, Ahmet
dc.contributor.authorErdem, Havva
dc.contributor.authorKarataş, Zehra
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorÇakmak, Bülent
dc.date.accessioned2020-04-30T23:33:10Z
dc.date.available2020-04-30T23:33:10Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000395199200003en_US
dc.descriptionPubMed: 28013561en_US
dc.description.abstractPendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.en_US
dc.identifier.doi10.1080/01443615.2016.1174825en_US
dc.identifier.endpage14en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2016.1174825
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4912
dc.identifier.volume37en_US
dc.identifier.wosWOS:000395199200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPendrinen_US
dc.subjectplacentaen_US
dc.subjectsmokingen_US
dc.subjectthiocyanateen_US
dc.titleThe effect of smoking on placental pendrin expressionen_US
dc.typeArticleen_US

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