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Öğe Evaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomas(Springer India, 2015) Havva, Erdem; Feyza, Basar; Nilufer, Kadioglu; Murat, Oktay; Handan, Ankarali; Ali, Yavuzcan; Serdar, Dilbaz; Erdem, Havva; Başar, Feyza; Kadıoğlu, Nilüfer; Murat, Oktay; Ankaralı, Handan; Yavuzcan, Ali; Dilbaz, SerdarApproximately, one fourth of women have leiomyomas. Leiomyomas are benign tumors that originated from smooth muscle cells. Estrogen is claimed to relate as a cause but exact mechanism has not fully understood. In this study, 95 leiomyoma cases that have been diagnosed by our department in years between 2010 and 2012 were examined. Age ranges of patients, sizes, locations, and numbers of leiomyomas were identified. Immunohistochemically ER (estrogen), PR (progesterone), and Gross cystic disease fluid protein-15 stains were performed to the paraffin blocks and their percentages of staining were noted. Statistically, submucosal and intramural locations were significantly related to ER and PR (p < 0,001). There were significant relationship between ER and PR in 30-50 years age group (p < 0,001). There were significant relationship between ER, PR and locations (p < 0,001), numbers (p < 0,001), sizes of leiomyomas (below 5 cm; p < 0,001), (between 5 and 10 cm; p = 0,037), larger than 10 cm; p = 0,002). Consequently, relationship between leiomyoma and ER, PR were revealed in this study. Also, relationship between leiomyoma locations and patient ages were identified statistically. There was no immunoreactivity with GCDFP-15 in leiomyomas.Öğe Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome(Professional Medical Publications, 2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Balbay, Ege Güleç; Kaya, MuratObjective: To evaluate the intraocular pressure (IOP), central corneal thickness (CCT), and peripapillary retinal nerve fiber layer (RNFL) thickness in Patients with Obstructive Sleep Apnea Syndrome. Methods: In this prospective study, 103 patients with OSAS (study group) and 37 healthy subjects were enrolled. All participants underwent comprehensive ophthalmic examinations. Mean outcome measures were intraocular pressure by Goldmann applanation tonometry, CCT measurement using ultrasound pachymeter and peripapillary RNFL thickness measured by spectral-domain optical coherence tomography. Results: The differences between the mean values of RNFL thickness in all quadrants were similar in both groups and were not statistically significant (p=0.274). The IOP and CCT measurement averages of all patients with OSAS were lower than the control group. However, this difference was not statistically significant. There was no correlation between the apnea-hypopnea index, lowest oxygen saturation (LAST) or Body Mass Index (BMI) and the peripapillary RNFL thickness, IOP or CCT when OSAS group was divided by severity. Conclusions: The study results suggest that peripapillary RNFL thickness, IOP or CCT did not differ significantly between OSAS and control groups. We also found no correlation between apnea severity (AHI), lowest oxygen saturation (LAST) and BMI and RNFL, CCT and IOP.Öğe Evaluation of middle ear pressure in the early period after adenoidectomy in children with adenoid hypertrophy without otitis media with effusion(W B Saunders Co-Elsevier Inc, 2015) Ünlü, İlhan; Ünlü, Elif Nisa; Kesici, Gülin Gökçen; Güçlü, Ender; Yaman, Hüseyin; İlhan, Ethem; Memiş, MehmetObjective: Our aim was to analyze the changes in middle ear pressure in the early period after adenoidectomy in children with adenoid hypertrophy without otitis media with effusion. Methods: This prospective, descriptive study was performed on 64 patients (with normal tympanic membranes and tympanograms) undergoing adenoidectomy or adenotonsillectomy. All patients were operated by single experienced team using curettage technique. First tympanometry was done on the day before surgery. Tympanometry was repeated on the first-, third-, and seventh-day after the operation. Patients are separated into two groups according to age as patients younger than 6 years (Group A) and patients older than 6 years (Group B). All data were separately evaluated for each ear using Jerger Classification. Results: Of the 64 patients included in the study, 35 were male and 29 were female, and the average age was 91.01 +/- 37.4 (35-178) months. Pathological decreases in the middle ear pressures of at least one ear were determined in 48 (75%) patients on the first postoperative day and in 10 (15.6%) patients on the third postoperative day. Middle ear pressures returned to preoperative values by the seventh postoperative day except in two patients. There were statistically significant differences (p <0.0001) among preoperative and first, third, and seventh postoperative day mean middle ear pressure. There were no statistically significant differences between Groups A and B in terms of tympanometry values of both ears obtained preoperatively and on the first, third, and seventh postoperative day. Conclusion: In our study, temporary eustachian dysfunction and aural fullness occur in the early period after adenoidectomy and/or adenotonsillectomy. This situation may be due to post-surgery clots and edema in nasopharynx. We consider that tubal orifice can be exposed to surgical trauma as adenoidectomy surgeries are done by curettage technique. There is a need for comparative studies using microdebrider or laser adenoidectomy accompanied by an endoscope. (C) 2015 Elsevier Inc. All rights reserved.Öğe Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency(Springer, 2019) Akcan, Fatih Alper; Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Ünlü, İlhanObjectivesThe main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.MethodsA total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.ResultsThe mean 25(HO)Vitamin-D levels were 14.324.23ng/mL (7-24.6) and 29.38 +/- 7.05ng/mL (25-53.8) in study and control groups, respectively (p<0.001). The mean NMC time was 11.15 +/- 3.05 (6.3-17.6) and 8.40 +/- 2.33 (6-13.2) in study and control groups, respectively (p<0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 +/- 10.03 and the mean NMC time was 9.56 +/- 2.54 (p<0.001).Conclusion The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.Öğe Evaluation of Outcomes in Patients Given Dexmedetomidine in Functional Endoscopic Sinus Surgery(Annals Publ Co, 2011) Güven, Damla Güçlü; Demiraran, Yavuz; Sezen, Gülbin; Kepek, Ökkeş; İskender, AbdülkadirObjectives: We aimed to evaluate the effects of dexmedetomidine hydrochloride (DEX) on hemodynamic parameters and on surgeon and patient satisfaction during functional endoscopic sinus surgery (FESS). Methods: Forty patients who were to undergo FESS were enrolled in this randomized, prospective, controlled study. In the DEX group, conscious sedation was induced with an infusion of 1 mu g/kg of DEX 10 minutes before surgery, followed by an infusion of DEX at 0.2 mu g/kg per hour. A control group was given identical amounts of saline solution. During the procedure, hemodynamic data were recorded. The patients evaluated their pain on a visual analog scale (VAS). Intraoperative bleeding was rated on a 6-point scale for evaluation of operative field visibility. Results: We observed that the DEX group had lower bleeding scores (p = 0.019). The heart rates were lower in the DEX group at the time of induction (p = 0.052) and in the 1st (p = 0.009) and 20th minutes (p = 0.039) of induction. The mean blood pressure values were lower in the DEX group in the 5th (p < 0.001), 45th (p = 0.003), and 60th (p = 0.05) minutes of induction. The VAS score was lower in the DEX group in the 30th postoperative minute (p = 0.001); however, the VAS score was lower in the control group after the 12th hour (p < 0.001). Postoperative side effects such as nausea, tachycardia, hypotension, and vomiting were significantly less frequent in the DEX group (p < 0.001). Conclusions: We observed that the intraoperative bleeding, hemodynamic stability, and VAS scores were better and the side effects were less frequent in the DEX group.Öğe Evaluation of Quality of Life After Bilateral Endoscopic Thoracic Sympathectomy for Primary Hyperhidrosis(Wroclaw Medical Univ, 2010) Şanlı, Aydın; Önen, Ahmet; Karapolat, Sami; Eyüboğlu, Gün Murat; Taşdöğen, Aydın; Ulugün, İlknur; Özdemir, NezihBackground. Primary hyperhidrosis is a disorder from which 1% of the society suffers. Objectives. This present study is aimed to evaluate the effects of endoscopic thoracic sympathectomy on the primary hyperhidrosis. Material and Methods. Between February 2008 and April 2010, 30 patients with primary hyperhidrosis underwent endoscopic thoracoscopic sympathectomy. Before the operation, 4 (13.3%) cases had sweating on scalp with flushing on the forehead. There was primary palmar hyperhidrosis in 25 (83.3%) cases, facial hyperhidrosis in 17 (56.6%) cases and primary plantar hyperhidrosis in 19 (63.3%) cases. The second and the third thoracic sympathetic ganglia were bilaterally cauterized in 6 (20.0%) of the cases, while 2(nd), 3(rd) and 4(th) thoracic sympathetic ganglia were bilaterally cauterized in 24 (80.0%) cases. Results. Quality of life was evaluated by Hyperhidrosis Disease Severity Scale in preoperative and postoperative period. Before the operation, 10 (33.3%) cases expressed that hyperhidrosis was barely tolerable followed by 20 (66.7%) cases expressing that hyperhidrosis was intolerable. After the operation, compensatory sweating was never noticeable in 8 (26.6%) cases, tolerable in 15 (50.0%) cases, barely tolerable in 5 (16.7%) cases, intolerable in 2 (6.6%) cases. In order to assess the quality of life before and after the operation, a scale between 1 (very poor) and 10 (very good) has been implemented. It was found that average before the operation was 7 (2-8), while average after the operation was 8.2 (6-10) (P < 0.001). Conclusions. Endoscopic thoracic sympathectomy is most efficient treatment method of primary hyperhidrosis for enhancing the quality of life (Adv Clin Exp Med 2010, 19, 5, 619-624).Öğe Experimental Esophagitis Model Preventing Tracheal Aspiration(Wroclaw Medical Univ, 2015) Kiraz, Hasan A.; Erbaş, Mesut; Küçük, Adem; Topaloğlu, Naci; Erdem, Havva; Şahin, Hasan; Kiraz, AslıBackground. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered.Öğe Experimental fascial flap model in the dog: Free flap of the dorsal thoracic fascia(Thieme Medical Publ Inc, 2003) Uğurlu, Kemal; Özer, Kürşat; Hüthüt, İlkay; Özçelik, Derya; Tatlıdede, Soner; Egeman, Onur; Baş, LütfüFor years, various types of fascial flaps have been used in clinical practice; however, there are many unanswered questions regarding their basic physiology, anatomy and histopathologic changes occurring after transfer. Simple and reliable flap models are needed to investigate these questions, but very few of these flap models have been described in experimental animals to date. The purpose of this study was to describe a new reliable fascia flap model in the dog-the dorsal thoracic fascia flap. This fascia is defined as the anatomic layer that contains the blood supply to the scapular and parascapular fasciocutaneous flaps. Fourteen adult dogs were used in this experiment. The vascular anatomy of the dorsal thoracic fascia was studied by anatomic dissection and micro angiography. Anatomic dissection revealed that the main axial vessel supplying the dorsal thoracic fascia was the superficial branch of the thoracodorsal vessel. Based on the vascular pedicle, fascia flaps generally measuring 15x24 cm were created. At gross observation, all of these large flaps based solely on the vascular pedicle were observed to be well-perfused. Microangiographic examination revealed the intense vascularity of the superficial branches of the thoracodorsal vessels in the whole area of all flaps. It was concluded that this is a simple and reliable fascial flap model which can be prepared as a free or pedicled flap. It has a consistent, long vascular pedicle with large vessel diameters supporting a large fascial flap.Öğe Evaluation of the Clinical Efficacy of Using Thermal Camera for Cryotherapy in Patients with Total Knee Arthroplasty: A Prospective Study(Mdpi, 2019) Karaduman, Zekeriya Okan; Turhal, Ozan; Turhan, Yalçın; Orhan, Zafer; Arıcan, Mehmet; Uslu, Mustafa; Cangür, ŞengülBackground and objectives: Cryotherapy is a method of treatment using cold application. This study aimed to evaluate postoperative clinical and hematological parameters and pain associated with total knee arthroplasty in patients and compared cryotherapy to the conventional method of cold ice pack compressions. Materials and Methods: Between January 2015 and January 2016, 90 patients who underwent total knee arthroplasty for grade 4 gonarthrosis were prospectively evaluated. The patients were divided into three groups (n = 30, each): Group 1, cryotherapy was applied in the pre- and postoperative periods; Group 2, cryotherapy was applied only in the postoperative period; and Group 3 (control group), only a cold pack (gel ice) was applied postoperatively. In all groups, pre- and postoperative evaluations at 6, 24, and 48 h, hemorrhage follow-up, knee circumference measurement, visual analog scale pain score, knee circumference, and temperature measured by thermal camera were recorded. Results: Of the 90 patients, 10% were men and 90% were women. The mean age was 64.3 +/- 8.1 (range: 46-83) years. The patella upper end diameter values were significantly lower in the postoperative period in Groups 1 and 2 than in Group 3 (p = 0.003). Hemoglobin levels at 24 and 48 h postoperatively were significantly lower in Group 3 than in Group 1 (p < 0.001, each) and Group 2 (p = 0.038, p < 0.001). At 6, 24, and 48 h follow-ups, pain values were significantly lower in Group 2 than in Group 3 (p < 0.001). Preoperative 6, 24, and 48 h temperature values were significantly lower in Group 1 than in Group 3 (p < 0.001 for each). It was found that the difference between preoperative and postoperative knee flexion measurements was significantly different in both groups or the difference between the groups was changed in each period (p < 0.001). Conclusions: Postoperative cryotherapy is a potentially simple, noninvasive option and beneficial for the reduction of reducing pain, bleeding, length of stay, analgesic requirement and swelling after total knee arthroplasty. Moreover, there was no early or late prosthesis infection in cryotherapy groups, which may be considered as an additional measure to prevent prosthesis infection.Öğe Endometrial Örnekleme Yapılan Hastaların Sonografik Bulgularının ve Histopatolojik Sonuçlarının Değerlendirilmesi(Duzce Univ, 2018) Özbilgeç, Sıtkı; Kaya, Aşkı Ellibeş; Başbuğ, AlperAmaç: Bu çalışmanın amacı, endometrial örnekleme yapılan olgularda histopatolojik sonuçlar ve sonografik veriler arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Düzce Üniversitesi Tıp Fakültesi Hastanesi‘nde Ocak 2015 - Ocak 2017 yılları arasında endometrial örnekleme yapılan hastaların sonuçları retrospektif olarak hastane otomasyon sisteminden ve hasta dosyalarından incelenerek değerlendirildi. Hastalar menopozal durumlarına göre premenopoz ve postmenopoz olarak sınıflandırılarak, hasta gruplarındaki sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Hastaların 231‘i premenopozal, 202‘si postmenopozal dönemde idi. Premenopozal hastaların ortalama endometrial kalınlıkları 10,42 ± 6,75 (mm, mean±SD) iken, postmenopozal hastaların endometrial kalınlık ortalamaları 10,01 ± 7,26 (mm, mean±SD) bulundu. Premalign lezyonların görülme oranı, her iki grupta benzer bulundu (p=0,87, p=0,54). Postmenopozal 10 hastada malignite tanısı konuldu, bu hastaların tümünün ilk başvuru şikayeti postmenopozal kanamaydı. Yapılan ROC analiz ile malignite için endometrial kalınlık sınır değeri; 8,5 mm olarak bulundu. Premenopozal dönemde, endometrial polip % 22,1 (n=51) oranında izlenirken, postmenopozal dönemde %16,3 (n=33) oranında izlendi (p=0,014). Tamoksifen kullanan 8 hastanın patoloji sonucu %75 (n=6) benign, %12,5 (n=1) premalign, %12,5 (n=1) malign olarak raporlandı. Sonuç: Postmenopozal kanamalı hastalarda endometrial örnekleme malignite ekartasyonu açısından hayatidir.Öğe Evaluation of the inferior turbinate in patients with deviated nasal septum by using computed tomography(Lippincott Williams & Wilkins, 2004) Egeli, Erol; Demirci, Levent; Yazıcı, Burhan; Harputluoğlu, UğurObjectives/Hypothesis. The objective was to measure the dimensions, composition, and possible structural and radiological changes of the compensatory hypertrophic inferior turbinate in patients with deviated nasal septum. Study Design: A prospective, non-randomized clinical trial at a university medical center. Methods. Twenty-three patients with deviated nasal septum and compensatory hypertrophy of the inferior turbinate in the contralateral nasal cavity were examined by computed tomography. Results. The dimensions of the compensatory hypertrophic inferior turbinate in patients with septal deviation were compared with normal control subjects. The difference in width of the medial and lateral mucosa and the conchal. bone between the two groups was statistically significant (P <.05). Conclusion. The present study uncovers the dimensions and composition of the inferior turbinate with compensatory hypertrophy in patients with nasal septum deviation. The findings support the decision to excise the inferior turbinate bone at the time of septoplasty, because of the significant bony and mucosal expansion.Öğe Evaluation of the outcomes of laparoscopic hysterectomy for normal and enlarged uterus (> 280 g)(Springer Heidelberg, 2014) Yavuzcan, Ali; Çağlar, Mete; Üstün, Yusuf; Dilbaz, Serdar; Kumru, SelahattinThe aim of this study was to evaluate intraoperative and postoperative outcomes of laparoscopic hysterectomy (LH) with routine intraoperative cystoscopy (CYS) for enlarged uterus (> 280 g). The patients, who underwent LH procedure in the Department of Obstetrics and Gynecology in Duzce University Faculty of Medicine between July 2012 and July 2013, were included in this study. Perioperative outcomes were compared between patients with and without enlarged uterus. Uterus weight of the operated patients ranges between 38 and 700 g. Mean uterus weight was 196.40 +/- A 142.32 g. Although we found longer operation time (148.75 +/- A 32.37 vs. 128.28 +/- A 27.58) and higher delta hemoglobin (2.98 +/- A 3.09 vs. 1.61 +/- A 1.29) in patients with enlarged uterus undergoing LH, these findings were not statistically significant (p = 0.077 and 0.058). No significant difference was found between the two groups in terms of need for insertion of pelvic drainage (p = 0.664), duration of bladder catheterization (p = 0.673), time of first postoperative flatus (p = 0.509) and the duration of hospitalization (p = 0.844). None of the patients had postoperative fever. The two groups were not significantly different in terms of postoperative body temperature (p = 0.736). In normal uterus group, 1 patient developed ureterovaginal fistula and 1 patient required re-operation. No major complication was observed in large uterus group. In our study, we compared the outcomes of LH in patients with large uterus measuring up to 700 g. and patients with normal uterus, and we achieved successful results by making minor changes in the operation technique and performing diagnostic CYS at the end of the operation.Öğe Evaluation of the effects of desflurane and sevoflurane anesthesia on alveolar epithelial permeability by Tc-99m DTPA inhalation scintigraphy(Tubitak Scientific & Technical Research Council Turkey, 2013) İskender, Abdülkadir; Erkan, Melih Engin; Erbaş, Mesut; Güven, Damla Güçlü; Sezen, Gülbin; Aşık, Muhammet; Yıldırım, MustafaAim: Recently studies showed that volatile anesthetics affect the ciliary beat frequency in vitro. We know that impairment of ciliary beat frequency is related to a risk of pulmonary complications with general anesthesia. Other studies have also shown that exposure to a volatile anesthetic can increase the permeability of the alveolar-capillary barrier. The present study aimed to determine the effects of desflurane and sevoflurane anesthesia on the technetium-labeled diethylene triamine penta-acetic acid (Tc-99m DTPA) clearance rate of the alveolar epithelium. Materials and methods: A total of 40 patients who underwent elective tympanoplasty with general anesthesia were included in this study. Patients having any systemic disease or infection, or with any property that affected lung functions, were excluded from the study. Patients were randomized into 2 groups (20 patients in each) as receiving sevoflurane and desflurane. A Tc-99m DTPA aerosol inhalation lung imaging method was used to assess lung functions. Results: Demographic properties were similar in both groups. There were no significant differences between basal and postoperative lung clearance of inhaled Tc-99m DTPA in either group. Conclusion: We propose that neither sevoflurane nor desflurane induces pulmonary alveolar capillary injury in the acute period of general anesthesia based on Tc-99m DTPA scan results.Öğe Evaluation of Different Surgical Techniques to Repair Iatrogenic Esophageal Injury; an Experimental Study(Journal Neurological Sciences, 2015) İş, Merih; Pehlivan, Mevlüt; Akyüz, Fevzullah; Çelikoğlu, Erhan; Gökçe, Aysun; Aytekin, Hikmet; Altay, TamerObjective: Esophageal perforation during anterior spine surgery is a rare but serious complication that may lead to death, if not managed properly. Optimal management of these injuries is still debated, which varies from conservative approach to different types of surgical repair. The purpose of this study was to evaluate and compare the healing process following various surgical techniques to repair experimentally induced esophageal injury in rodents. We hypothesized that repair techniques that involve flap rotation along with primary suture was superior to primary suture alone. Material and Methods: Fifty male Sprague-Dawley rats were used for this study. Esophageal injury was induced by a vertical incision through all layers of its wall. Groups were determined according to the repair techniques used, i.e., Group-1 (sham, no injury), Group-2 (primary suture), Group 3 (primary suture plus muscle flap), Group 4 (primary suture omental flap) and Group 5 (untreated). Esophageal segments repaired were obtained fourteen days after the injury/repair surgery for histopathological evaluation. Results: Total histopathological damage scores were highest in Group 5. Lower total scores were obtained in Group 3 than in Group 2 and 5, whereas total scores between Groups 2 and 4, 2 and 5, and 3 and 4 were similar. Infiltration and submucosal/muscular healing scores were higher in Group 2 than in 3. There was no difference in any of the parameters between groups 2 and 4, 2 and 5, and 3 and 4. Conclusions: Primary suture closure reinforced by a muscle flap provides better healing in a rat model of iatrogenic esophageal injury. Primary suture reinforced by omentum, or primary suture alone may be considered as second options for repair.Öğe Evaluation of deaf children in a large series in Turkey(Elsevier Ireland Ltd, 2005) Öztürk, Özcan; Sılan, Fatma; Oğhan, Fatih; Egeli, Erol; Belli, Şeyda; Tokmak, Abdurrahman; Zafer, CansuObjective: Evaluation of the deafness etiology, ear examination findings and hearing levels of deaf children in a large series. Patients and methods: We studied 840 deaf primary school children (486 mate, 354 female, mean age 12.69 +/- 3.52, range 5-22). A questionaire investigating the prenatal, perinatal and postnatal etiological causes was prepared and pedigree analysis was performed. After ENT examination, odyologic tests were performed. Results: The etiological features of deafness were found for genetic causes as 429 cases (51.1%), 127 children (15.1%) for acquired group and 284 children (33.8%) for unknown group. We confirmed 136 (15.5%) syndromic deaf children and 19 of them (13.9%) were autosomal recessive (AR), 105 of them (77.2%) were autosomal dominant (AD), six (4.4%) of them were X-linked. Two hundred and ninety-three deaf (33.4%) children were in the familial nonsyndromic group. In this group, the inheritance of 255 (87%) were AR, 23 (7.8%) were AD and 15 (5.2%) were X-linked recessive. Febrile convulsion was identified as the most common etiology in 36 (4.3%) cases in the acquired group. Three hundred and twenty-two (67.7%) children had profound HL (above 91 dB), 111 (23.3%) had severe HL and 43 (9%) had moderately severe HL. Sensorineural. HL was found in 439 (92.2%) and mixed type hearing loss was seen 37 (7.8%) of 476 cases. We found many major and minor abnormalities and ocular, ear and dental pathologies. The prevalence of ear diseases was found in 203 (24.2%) of children. Impacted wax was found in 80 (9.5%) of 840 children with otoscopic examination and was the most common pathology, retraction in 70 (8.3%) and perforation in 15 (1.8%) followed it. Conclusion: Preventable ear disease are important health problems among school children for the deaf because these diseases can affect the real level and type of deafness, so determining early diagnostic criteria, ear diseases and minor abnormalities is important for early rehabilitation. Syndromes can be prevented in pregnancy, infections can be prevented in prenatal or postnatal period but unknown group cannot be prevented although the unknown etiology can be reduced by multidiciplinary approach. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester(Duzce Univ, 2018) Teberik, Kuddusi; Başbuğ, Alper; Sağlam, Hakan; Karaaslan, Musa; Kaya, MuratObjective: To analyze the effects of pregnancy on anterior segment parameters and retinal nerve fiber layer (RNFL) thickness. Methods: The study designed prospectively conducted among 122 singleton pregnant women and 49 non-pregnant women. Intraocular pressure (IOP) was measured via the Goldman applanation tonometry. Central corneal thickness (CCT), axial lenght (AxL) and anterior chamber depth (ACD) measurement were performed with Echoscan US 500. For investigating the thickness of RNFL in detail, the optical coherence tomography was used. One Way ANOVA test was used to make a comparison between normal distribution groups. Results: There was no statistically significant difference regarding age. The IOP were 16.0 mmHg in the 1st trimester, 14.6 mmHg in the 2nd trimester, 13.6 mmHg in the 3rd trimester and 15.56 mmHg in the non-pregnant. Statistically, the findings of the 2nd and the 3rd trimester were significantly different from that of the 1st trimester (p = 0.033, p = 0.001, respectively). CCT averages were 554 mu m, 564 mu m and 552 mu m, respectively, according to the trimester, while it was 542 mu m in non-pregnant women. The difference between CCT averages between pregnancies in the 2nd and 3rd trimesters and non-pregnant women was statistically significant (p = 0.022, p = 0.041, respectively). The comparison of average thickness of four RNFL showed no difference between the pregnant and non-pregnant. Conclusions: During gestation, there was an increase in CCT with a decrease in IOP. We also determined that the ACD, AxL, and RNFL thickness measurements do not change with pregnancy.Öğe Etiology of deafness at the Yeditepe School for the deaf in Istanbul(Elsevier Sci Ireland Ltd, 2003) Egeli, Erol; Çiçekçi, Günferi; Sılan, Fatma; Öztürk, Özcan; Harputluoğlu, Uğur; Onur, Aşkın; Yıldız, AyselObjective: The etiology of deafness can be classified as genetic, acquired and unknown. An unknown etiology was a high incidence in previous reports. The aim of this study is to explore the etiology of deafness and to reduce the cases in the unknown group. Methods: This study was conducted on 162 students at the Yeditepe School for the deaf. Otologic, physical and psychological. examinations were performed by a team of doctors including four otologists, a geneticist, a dentist, an ophthalmologist and an audiologist. Results: A genetic cause was identified in 41.35%, acquired 37.65% and unknown 20.98%. Genetic etiologies were stratified as familial and syndromic subgroups. A familial cause was found in 60 of 162 children and in 22 of those 60 cases, the parents had a consanguineous marriage. There was 11 cases associated with a syndrome. Ninety four minor abnormalities have been established in some deaf children. Febrile convulsion (36%) was identified as the most common etiology in acquired cases. Conclusion: In contrast with other studies the consanguineous marriage was present in 36.6% of the familial cases and 38.8% in total of the school. An unknown etiology was reported in high rates in previous reports. These unknown cases could be described as a part of a syndrome by a crowded team of consultants. Evaluation of early diagnostic criterias and minor abnormalities can help us to provide early rehabilitation of deafness in childhood. Published by Elsevier Science Ireland Ltd.Öğe Estimating the chance of success in IVF treatment using a ranking algorithm(Springer Heidelberg, 2015) Güvenir, H. Altay; Mısırlı, Gizem; Dilbaz, Serdar; Özdeğirmenci, Özlem; Demir, Berfu; Dilbaz, BernaIn medicine, estimating the chance of success for treatment is important in deciding whether to begin the treatment or not. This paper focuses on the domain of in vitro fertilization (IVF), where estimating the outcome of a treatment is very crucial in the decision to proceed with treatment for both the clinicians and the infertile couples. IVF treatment is a stressful and costly process. It is very stressful for couples who want to have a baby. If an initial evaluation indicates a low pregnancy rate, decision of the couple may change not to start the IVF treatment. The aim of this study is twofold, firstly, to develop a technique that can be used to estimate the chance of success for a couple who wants to have a baby and secondly, to determine the attributes and their particular values affecting the outcome in IVF treatment. We propose a new technique, called success estimation using a ranking algorithm (SERA), for estimating the success of a treatment using a ranking-based algorithm. The particular ranking algorithm used here is RIMARC. The performance of the new algorithm is compared with two well-known algorithms that assign class probabilities to query instances. The algorithms used in the comparison are Na < ve Bayes Classifier and Random Forest. The comparison is done in terms of area under the ROC curve, accuracy and execution time, using tenfold stratified cross-validation. The results indicate that the proposed SERA algorithm has a potential to be used successfully to estimate the probability of success in medical treatment.Öğe Esthesioneuroblastoma located in the thoracic extradural space: Case report(Elsevier Sci Ltd, 2016) Akgül, Mehmet Hüseyin; Gezen, Ferruh; Uzunlar, Ali KemalOBJECTIVE: Esthesioneuroblastoma accounted for only 6% of the malignant nasal cavity neoplasms (ENB) is a rare tumor which originates from the olfactory epithelium. ENB's are locally agresive and can metastasize by lymphatic and hematogenous routes. A patient with the mass on the nasal dorsum was reported in this article. CASE HISTORY: A 52-year-old-man admitted to the hospital with a 3 months history of progressive nasal obstruction, epistaxis and mass on the nasal dorsum. On rhinoscopy, a polypoid mass was seen in the both nasal cavity and intrana sal biopsy with local anesthesia was performed. Hi stopathologic diagnosis of the tumor was Kadish stage B esthesioneuroblastoma. Tumor was excised by using bilateral endoscopic endonasal resection and lateral rhinotomy approach and paranasal radiotherapy performed postoperatively. Ten months after surgery, neck metastasis was occured and patient was underwent neck dissection. Twenteeth months after initial treatment, distant metastasis was identified on the T 10 vertebra and following the cranial and spinal radiotherapy to the neck he was free of local recurrence at follow up 13 months after surgery. CONCLUSION: It has been known that the metastasis of the ENB to the spinal cord is an uncommon event, and it occurs often years after initial diagnosis. MRI scan is helpful for making the diagnosis, and surgery is the treatment of choice for obtaining diagnostic tissue and debulking the tumor. Radiotherapy is also a mainstay of postoperative treatment. (C) 2016 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.Öğe Epiglottic tuberculosis in a patient treated with steroids for Addison's disease(Tohoku Univ Medical Press, 2003) Egeli, Erol; Oğhan, Fatih; Alper, Murat; Harputluoğlu, Uğur; Bulut, İsmetIsolated epiglottic tuberculosis (TBC) is uncommon and has rarely been described. We report the case of a 40-year-old man with tuberculous involvement of the epiglottis and primary adrenal insufficiency. Endoscopic examination showed a severely swollen epiglottis with granulomatous and partially necrotic mucosa. The patient has been treated with glucocorticoids for four years due to primary adrenocortical. insufficiency. We therefore assume that tuferculous involvement of epiglottis is due to the reactivation of pulmonary TBC. We also discuss differential diagnosis and management of epiglottic TBC and Addison's disease.
