The effect of smoking on placental pendrin expression
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.
Açıklama
WOS: 000395199200003
PubMed: 28013561
PubMed: 28013561
Anahtar Kelimeler
Pendrin, placenta, smoking, thiocyanate
Kaynak
Journal Of Obstetrics And Gynaecology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
37
Sayı
1
