Scintigraphic and Histopathologic Evaluation of Combined Bone Grafts

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dc.contributor.authorAtılgan, Hasan İkbal
dc.contributor.authorDemirel, Koray
dc.contributor.authorKankaya, Yüksel
dc.contributor.authorOktay, Murat
dc.contributor.authorŞahiner, Cem
dc.contributor.authorKorkmaz, Meliha
dc.contributor.authorKankaya, Duygu
dc.date.accessioned2020-04-30T23:31:47Z
dc.date.available2020-04-30T23:31:47Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444;en_US
dc.descriptionWOS: 000330354500040en_US
dc.descriptionPubMed: 24220371en_US
dc.description.abstractObjectives: We aimed to assess various bone grafts on bone formation using bone scintigraphy and histology, especially the first study that evaluated the demineralized bone matrix (DBM) + tricalcium phosphate (TCP) + hyaluronic acid (HA) combination. Materials and Methods: A total of 44 pieces in groups of autogenous bone graft, TCP, DBM, DBM + TCP combination, and DBM + TCP + HA combination were applied to parietal bones of 24 New Zealand rabbits. Bone scintigraphies of the rabbits were performed at 2, 6, and 12 weeks. The uptake ratios were compared for the different types of grafts. In addition, in 2, 6, and 12 weeks, the graft areas were taken from the sacrificed rabbits and examined histologically. Results: In the 2-week evaluation, DBM + TCP combination and DBM + TCP + HA combination had more osteoblastic activity accumulation than the TCP and DBM groups. These findings supported that the DBM + TCP combination group showed new bone formation earlier in the histopathological evaluation. The DBM + TCP + HA combination had more uptake than the TCP and DBM groups on bone scintigraphy at 2 weeks, and this uptake ratio decreased in the following weeks. It was thought that the increased uptake in DBM + TCP + HA combination at 2 weeks was due to severe inflammation seen in the histopathological evaluation. Conclusion: The DBM + TCP + HA combination should not be used for graft repair, although it was thought to be a good combination in the early weeks.en_US
dc.identifier.doi10.1097/SCS.0b013e3182a24742en_US
dc.identifier.endpage1907en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1902en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0b013e3182a24742
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4464
dc.identifier.volume24en_US
dc.identifier.wosWOS:000330354500040en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone scintigraphyen_US
dc.subjectdemineralized bone matrix (DBM)en_US
dc.subjecttricalcium phosphate (TCP)en_US
dc.subjecthyaluronic acid (HA)en_US
dc.titleScintigraphic and Histopathologic Evaluation of Combined Bone Graftsen_US
dc.typeArticleen_US

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