Scintigraphic and Histopathologic Evaluation of Combined Bone Grafts
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: We aimed to assess various bone grafts on bone formation using bone scintigraphy and histology, especially the first study that evaluated the demineralized bone matrix (DBM) + tricalcium phosphate (TCP) + hyaluronic acid (HA) combination. Materials and Methods: A total of 44 pieces in groups of autogenous bone graft, TCP, DBM, DBM + TCP combination, and DBM + TCP + HA combination were applied to parietal bones of 24 New Zealand rabbits. Bone scintigraphies of the rabbits were performed at 2, 6, and 12 weeks. The uptake ratios were compared for the different types of grafts. In addition, in 2, 6, and 12 weeks, the graft areas were taken from the sacrificed rabbits and examined histologically. Results: In the 2-week evaluation, DBM + TCP combination and DBM + TCP + HA combination had more osteoblastic activity accumulation than the TCP and DBM groups. These findings supported that the DBM + TCP combination group showed new bone formation earlier in the histopathological evaluation. The DBM + TCP + HA combination had more uptake than the TCP and DBM groups on bone scintigraphy at 2 weeks, and this uptake ratio decreased in the following weeks. It was thought that the increased uptake in DBM + TCP + HA combination at 2 weeks was due to severe inflammation seen in the histopathological evaluation. Conclusion: The DBM + TCP + HA combination should not be used for graft repair, although it was thought to be a good combination in the early weeks.
Açıklama
oktay, murat/0000-0002-0893-4444;
WOS: 000330354500040
PubMed: 24220371
WOS: 000330354500040
PubMed: 24220371
Anahtar Kelimeler
Bone scintigraphy, demineralized bone matrix (DBM), tricalcium phosphate (TCP), hyaluronic acid (HA)
Kaynak
Journal Of Craniofacial Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
24
Sayı
6
