The effect of intra-arterial papaverine on ECoG activity in the ketamine anesthetized rat

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dc.contributor.authorKarataş, Ayşe
dc.contributor.authorGökçe, Fatih
dc.contributor.authorDemir, Şerif
dc.contributor.authorAnkaralı, Seyit
dc.date.accessioned2020-04-30T23:33:00Z
dc.date.available2020-04-30T23:33:00Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Seyit/0000-0003-3752-0846;en_US
dc.descriptionWOS: 000260614900012en_US
dc.descriptionPubMed: 18778752en_US
dc.description.abstractThe opium alkaloid papaverine (PPV) Causes vasodilatation of the cerebral arteries through direct action on smooth muscle that reduces the constriction of smooth muscle. Intra-arterial papaverine (IAP) has been used widely to increase the regional cerebral blood flow in order to reverse the cerebral vasospasm that occurs during endovascular procedures. IAP-induced seizures have been reported, although PPV has anticonvulsive effects. This study determined the effects of LAP on electrocorticography (ECoG) in the ketamine anesthetized rats. We used 24 Sprague-Dawley male rats weighing 200-250 g. The animals were divided randomly into four groups: three treatment groups (groups 1-3) and a control (group,4). Groups 1, 2, and 3 were given 1, 7, and 14 mg/kg IAP, respectively. The ECoG was compared across groups. Our results indicate(] that IAP did not cause seizures and that it decreased the frequency of ketamine-induced epileptiform activity in the 14 mg/kg group. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.neulet.2008.08.071en_US
dc.identifier.endpage61en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2008.08.071
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4872
dc.identifier.volume445en_US
dc.identifier.wosWOS:000260614900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapaverineen_US
dc.subjectEpilepsyen_US
dc.subjectRaten_US
dc.subjectVasospasmen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.titleThe effect of intra-arterial papaverine on ECoG activity in the ketamine anesthetized raten_US
dc.typeArticleen_US

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