Stage-specific transcriptome of Bursaphelenchus xylophilus reveals temporal regulation of effector genes and roles of the dauer-like stages in the lifecycle

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dc.contributor.authorTanaka, Suguru E.
dc.contributor.authorDayı, Mehmet
dc.contributor.authorMaeda, Yasunobu
dc.contributor.authorTsai, Isheng J.
dc.contributor.authorTanaka, Ryusei
dc.contributor.authorBligh, Mark
dc.contributor.authorKikuchi, Taisei
dc.date.accessioned2020-04-30T23:32:12Z
dc.date.available2020-04-30T23:32:12Z
dc.date.issued2019
dc.departmentDÜ, Ormancılık Meslek Yüksekokuluen_US
dc.descriptionFukuda, Kenji/0000-0002-9980-3107; Tsai, Isheng Jason/0000-0002-2123-5058; Kikuchi, Taisei/0000-0003-2759-9167en_US
dc.descriptionWOS: 000464495800004en_US
dc.descriptionPubMed: 30988401en_US
dc.description.abstractThe pine wood nematode Bursaphelenchus xylophilus is the causal agent of pine wilt disease, one of the most devastating forest diseases in East Asian and West European countries. The lifecycle of B. xylophilus includes four propagative larval stages and gonochoristic adults which are involved in the pathogenicity, and two stages of dispersal larvae involved in the spread of the disease. To elucidate the ecological roles of each developmental stage in the pathogenic life cycle, we performed a comprehensive transcriptome analysis using RNA-seq generated from all developmental stages of B. xylophilus and compared transcriptomes between stages. We found more than 9000 genes are differentially expressed in at least one stage of the life cycle including genes involved in general nematode biology such as reproduction and moulting but also effector genes likely to be involved in parasitism. The dispersal-stage transcriptome revealed its analogy to C. elegans dauer and the distinct roles of the two larval stages from each other regarding survival and transmission. This study provides important insights and resources to understand B. xylophilus parasitic biology.en_US
dc.identifier.doi10.1038/s41598-019-42570-7en_US
dc.identifier.issn2045-2322
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-019-42570-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4644
dc.identifier.volume9en_US
dc.identifier.wosWOS:000464495800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleStage-specific transcriptome of Bursaphelenchus xylophilus reveals temporal regulation of effector genes and roles of the dauer-like stages in the lifecycleen_US
dc.typeArticleen_US

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