Seasonal Association of Immune Thrombocytopenia in Adults

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dc.contributor.authorTombak, Anıl
dc.contributor.authorBoztepe, Burcu
dc.contributor.authorTiftik, Naci
dc.contributor.authorCömert, Melda
dc.contributor.authorSalim, Ozan
dc.contributor.authorAydın, Kaniye
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2020-04-30T23:31:48Z
dc.date.available2020-04-30T23:31:48Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionSaydam, Guray/0000-0001-8646-1673; GURKAN, EMEL/0000-0002-3060-4054en_US
dc.descriptionWOS: 000362846400002en_US
dc.descriptionPubMed: 26740892en_US
dc.description.abstractBackground: Immune thrombocytopenia (ITP) is an autoimmune disorder. It is characterized by thrombocytopenia due to thrombocyte destruction mediated by auto-antibodies; however, cytotoxic and defective regulatory T-lymphocytes play an important role in its pathogenesis. While childhood ITP is usually acute, self-limiting and generally seasonal in nature, ITP in adults is usually chronic; its relation with seasons has not been studied. Aims: We investigated whether months and/or seasons have triggering roles in adults with ITP. Study Design: Descriptive study. Methods: A retrospective case review of adult patients with primary ITP diagnosed at various University Hospitals in cities where Mediterranean climate is seen was performed. Demographic data, date of referral and treatments were recorded. Corticosteroid-resistant, chronic and refractory cases were determined. Relation between sex, corticosteroid-resistant, chronic and refractory ITP with the seasons was also investigated. Results: The study included 165 patients (124 female, mean age=42.8 +/- 16.6). Most cases of primary ITP were diagnosed in the spring (p=0.015). Rates of patients diagnosed according to the seasons were as follows: 35.8% in spring, 23% in summer, 20.6% in fall, and 20.6% in winter. With respect to months, the majority of cases occurred in May (18.2%). Time of diagnosis according to the seasons did not differ between genders (p=0.699). First-line treatment was corticosteroids in 97.3%, but 35% of the cases were corticosteroid-resistant. Steroid-resistant patients were mostly diagnosed in the spring (52.1%) (p=0.001). ITP was chronic in 52.7% of the patients and they were also diagnosed mostly in the spring (62.7%) (p=0.149). Conclusion: This is the first study showing seasonal association of ITP in adults and we have observed that ITP in adults is mostly diagnosed in the spring. The reason why more patients are diagnosed in the spring may be due to the existence of atmospheric pollens reaching maximum levels in the spring in places where a Mediterranean climate is seen.en_US
dc.identifier.doi10.5152/balkanmedj.2015.151223en_US
dc.identifier.endpage351en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2015.151223
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4473
dc.identifier.volume32en_US
dc.identifier.wosWOS:000362846400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergensen_US
dc.subjectimmune thrombocytopeniaen_US
dc.subjectpollenen_US
dc.subjectseasonsen_US
dc.titleSeasonal Association of Immune Thrombocytopenia in Adultsen_US
dc.typeArticleen_US

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