The effect of vitamin D status on different neuromuscular blocker agents reverse time
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Date
2020
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info:eu-repo/semantics/openAccess
Abstract
Background/aim: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times.Material and methods: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery undergeneral anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. Atthe end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigminewas administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was divided into twosubgroups according to sugammadex and group neostigmine in itself, with vitamin D levels above and below 30 ng/mL. Statisticalanalysis was performed on these 4 groups (Group neostigmine and vitamin D < 30 ng/mL), (Group neostigmine and vitamin D ? 30ng/mL), ( Group sugammadex and vitamin D < 30 ng/mL), (Group sugammadex and vitamin D ? 30 ng/mL).When two responses to train of four (TOF) stimulation were taken, the following times were recorded until extubation phase. The timeuntil TOF value 50%, 70%, 90%, and extubation were recorded.Results: There were statistically significant differences between Group sugammadex and vitamin D < 30 ng/mL and Group sugammadexand vitamin D ? 30 ng/mL (P = 0.007) for extubation times and 50% TOF reach times (P = 0.015). However, there was no differenceobserved between Group neostigmine and vitamin D < 30 ng/mL and Group neostigmine and vitamin D ? 30 ng/mL (P = 0.999).Conclusion: Vitamin D deficiency is important for anesthesiologists in terms of muscle strength and extubation time. Vitamin Ddeficiency seems to affect sugammadex reverse times but seems not to affect neostigmine reverse times. This conclusion needs furtherstudies.
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Journal or Series
Turkish Journal of Medical Sciences
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
50
Issue
4
