Erythropoietin stimulates patellar tendon healing in rats

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dc.contributor.authorUslu, Mustafa
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorOktay, Murat
dc.contributor.authorİnanmaz, Mustafa Erkan
dc.contributor.authorIşık, Cengiz
dc.contributor.authorKandiş, Hayati
dc.date.accessioned2020-05-01T12:11:54Z
dc.date.available2020-05-01T12:11:54Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Kursat/0000-0001-7550-6370; Kandis, Hayati/0000-0001-9151-6050; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000367634100003en_US
dc.descriptionPubMed: 26067853en_US
dc.description.abstractBackround: Erythropoietin (EPO), regulating erythropoiesis, is used to provide protective and regenerative activity in non-haematopoietic tissues. There is insufficient knowledge about the role of EPO activity in tendon healing. Therefore, we investigated the effect of EPO treatment on healing in rat patellar tendons. Methods: One hundred and twenty-six, four-month-old male Sprague-Dawley rats were randomly assigned to three experimental groups: 1, no treatment; 2, treatment with isotonic saline (NaCl) and 3, treatment with EPO. Each group was randomly subdivided into two groups for sacrifice at three (1a, 2a, 3a) or six weeks (1b, 2b, 3b). Complete incision of the left patellar tendon from the distal patellar pole was performed. We applied body casts for 20 days after the incised edges of the patellar tendon were brought together with a surgical technique. Both legs were harvested and specimens from each group underwent histological, biomechanical, and protein mRNA expression analyses. Results: There were statistically significant differences in the ultimate breaking force between the EPO group and others at both weeks three and six (p<0.05); significant differences in fibroblast proliferation, capillary vessel formation, and local inflammation were found between groups 1 a and 3a, and 2a and 3a (p<0.05). There were statistical differences between la, 3a and 2a, 3a for Col III, TGF-beta 1, and VEGF and between 1b, 3b and 2b, 3b for Col I, Col III, TGF-beta 1, and VEGF mRNA expressions. Conclusion: EPO had an additive effect with surgery on the injured tendon healing process in rats compared to the control groups biomechanically, histopathologically and with tissue protein mRNA expression. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2012.04.02.91]en_US
dc.description.sponsorshipAs a main author I received benefits for this research article by Duzce University Research Fund (project number 2012.04.02.91).en_US
dc.identifier.doi10.1016/j.knee.2015.01.011en_US
dc.identifier.endpage468en_US
dc.identifier.issn0968-0160
dc.identifier.issn1873-5800
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1016/j.knee.2015.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6260
dc.identifier.volume22en_US
dc.identifier.wosWOS:000367634100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofKneeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRaten_US
dc.subjectErythropoietinen_US
dc.subjectTendon healingen_US
dc.subjectPatellar tendon injuryen_US
dc.titleErythropoietin stimulates patellar tendon healing in ratsen_US
dc.typeArticleen_US

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