Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?

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dc.contributor.authorBahadır, Anzel
dc.contributor.authorEröz, Recep
dc.contributor.authorTürker, Yasin
dc.date.accessioned2020-05-01T09:11:30Z
dc.date.available2020-05-01T09:11:30Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000357329900002en_US
dc.descriptionPubMed: 25537992en_US
dc.description.abstractObjective: Diabetes mellitus is a major risk factor for cardiovascular disease (CVD). We investigated the relationship among biochemical and cardiac risk parameters with the methylenetetrahydrofolate reductase (MTHFR) C677T genotype in type 2 diabetes mellitus (T2DM) patients. Methods: One hundred seven T2DM subjects with severe CVD diagnosed by angiography were included consecutively in this cross-sectional study. Biochemical and clinical parameters were obtained from patients who were not positive for nephropathy and retinopathy. MTHFR C677T genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Normally and abnormally distributed continuous variables were analyzed using student t- and Mann-Whitney U tests. Categorical variables were analyzed using chi-square test. Results: In the study, 31 T2DM subjects had the CC (29.0%), 62 had the CT (57.9%), and 14 had the TT (13.1%) genotypes. There were no significant differences between subjects with wild-type (677CC) and with mutant (677CT+677TT) alleles in terms of diabetes duration, visceral fat area, total cholesterol, triglyceride, fasting plasma glucose, systolic blood pressure, diastolic blood pressure, high-sensitivity C-reactive protein, homocysteine (Hcy), and carotid intima-media thickness values. Conclusion: This study suggests that MTHFR gene polymorphisms can not be used as a marker for the assessment of cardiovascular risk in T2DM patients.en_US
dc.identifier.doi10.5152/akd.2014.5555en_US
dc.identifier.endpage530en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage524en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5555
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5624
dc.identifier.volume15en_US
dc.identifier.wosWOS:000357329900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subjectMTHFR C677T gene polymorphismen_US
dc.subjectcarotid intima-media thicknessen_US
dc.titleDoes the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?en_US
dc.typeArticleen_US

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