Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model

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dc.contributor.authorBahadır, Anzel
dc.contributor.authorCeyhan, Ayşe
dc.contributor.authorGergin, Özlem Öz
dc.contributor.authorYalçın, Betül
dc.contributor.authorÜlger, Menekşe
dc.contributor.authorÖzyazgan, Tuğçe Merve
dc.contributor.authorYay, Arzu
dc.date.accessioned2020-04-30T23:21:52Z
dc.date.available2020-04-30T23:21:52Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000429627900013en_US
dc.descriptionPubMed: 29521316en_US
dc.description.abstractObjective: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues. Methods: A total of 49 adult female Wistar albino rats were equally divided into seven groups as follows: control (no medication), sesame oil (1 mg/kg), CDDP (single dose injection two times as once a week, 5 mg/kg/week), BC (100 mg/kg), CDDP+BC (pretreated BC for 30 min before CDDP injection), CMN (200 mg/kg), and CDDP+CMN (pretreated CMN for 30 min before CDDP injection). These treatments were applied intraperitoneally for CDDP and with gavage for CMN and BC. The oxidative/antioxidant indicators, inflammatory cytokines, and histopathological alterations were examined. Results: These alterations included a marked increase in malondialdehyde (MDA) level, significant decrease in catalase (CAT) and superoxide dismutase (SOD) activities, and significant elevation of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, interleukin (IL)-6 in the CDDP group compared with the other groups. Histopathologically, CDDP-induced severe myocardial degenerative changes were observed. However, the CDDP-induced disturbances in the above-mentioned parameters significantly improved by treatment with BC and particularly CMN. Conclusion: This study indicated that CDDP treatment markedly caused cardiotoxicity; however, treatment with CMN or BC ameliorated this cardiotoxicity in rats. Furthermore, these findings revealed that treatment with CMN has a higher cardioprotective effect than that with BC against CDDP-induced cardiotoxicity in rat cardiac tissues.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2018.53059en_US
dc.identifier.endpage221en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2018.53059
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4262
dc.identifier.volume19en_US
dc.identifier.wosWOS:000429627900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcisplatinen_US
dc.subjectcardiotoxicityen_US
dc.subjectcurcuminen_US
dc.subjectbeta-caroteneen_US
dc.subjectrat heart tissueen_US
dc.titleProtective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat modelen_US
dc.typeArticleen_US

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