A REVERSIBLE THERMOSENSTTIVE ADHESIVE FOR RETINAL IMPLANTS In Vivo Experience with Plasma-deposited Poly(N-Isopropyl Acrylamide)

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dc.contributor.authorTunç, Murat
dc.contributor.authorHumayun, Mark
dc.contributor.authorCheng, Xuanhong
dc.contributor.authorRatner, Buddy D.
dc.date.accessioned2020-04-30T22:38:51Z
dc.date.available2020-04-30T22:38:51Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000260474200025en_US
dc.descriptionPubMed: 19430393en_US
dc.description.abstractPurpose: To study the in vivo effects of a thermosensitive retinal adhesive, plasma-polymerized N-isopropyl acrylamide (ppNIPAM), in rabbit eyes. Methods: Parylene C(poly(monochloro-p-xylylene)) (20 mu m) and poly(dimethyl siloxane) (PDMS) (>= 200 mu m) coated with ppNIPAM were used as implant materials. Following pars plana vitrectomy (PPV), ppNIPAM coated parylene (n = 3) and PDMS (n = 3) implants were inserted over the retina in six rabbits. Baseline and follow-up imaging (color fundus photographs, fluorescein angiography, and optic coherence tomography [OCT]) and electroretinogram recordings were performed. Histologic evaluation was performed following enucleation at 6 weeks. Results: Intraoperative retinal adhesion occurred in all eyes with ppNIPAM coated parylene and PDMS implants. Two eyes developed retinal tears during the implantation procedure and the ppNIPAM coated implants closed the retinal tears successfully preventing retinal detachment. OCT findings confirmed the retinal adhesion in all eyes. Four weeks after implantation one parylene and one PDMS implant detached partly from the retinal surface. Histology showed mild changes at the outer retinal segments. There was no evidence of ocular toxicity and inflammation. None of the eyes that had an implant covering the retinal tear developed a retinal detachment but had some inflammatory changes around the implants. Conclusions: ppNIPAM coated implants may provide retinal adhesion in vivo without measurable ocular toxicity in the short term. Covering a retinal tear, the ppNIPAM coated implants may prevent retinal detachment. RETINA 28:1338-1343, 2008en_US
dc.description.sponsorshipNational Science FoundationNational Science Foundation (NSF) [EEC 9529161]en_US
dc.description.sponsorshipSupported by the National Science Foundation to UWEB ERC (EEC 9529161).en_US
dc.identifier.doi10.1097/IAE.0b013e31817b6b42en_US
dc.identifier.endpage1343en_US
dc.identifier.issn0275-004X
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1338en_US
dc.identifier.urihttps://doi.org/10.1097/IAE.0b013e31817b6b42
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2486
dc.identifier.volume28en_US
dc.identifier.wosWOS:000260474200025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofRetina-The Journal Of Retinal And Vitreous Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthermosensitive plasma-polymerized N-isopropyl acrylamideen_US
dc.subjectretinal implantsen_US
dc.subjectretinal adhesionen_US
dc.subjectrabbit studyen_US
dc.titleA REVERSIBLE THERMOSENSTTIVE ADHESIVE FOR RETINAL IMPLANTS In Vivo Experience with Plasma-deposited Poly(N-Isopropyl Acrylamide)en_US
dc.typeArticleen_US

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