A REVERSIBLE THERMOSENSTTIVE ADHESIVE FOR RETINAL IMPLANTS In Vivo Experience with Plasma-deposited Poly(N-Isopropyl Acrylamide)
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To study the in vivo effects of a thermosensitive retinal adhesive, plasma-polymerized N-isopropyl acrylamide (ppNIPAM), in rabbit eyes. Methods: Parylene C(poly(monochloro-p-xylylene)) (20 mu m) and poly(dimethyl siloxane) (PDMS) (>= 200 mu m) coated with ppNIPAM were used as implant materials. Following pars plana vitrectomy (PPV), ppNIPAM coated parylene (n = 3) and PDMS (n = 3) implants were inserted over the retina in six rabbits. Baseline and follow-up imaging (color fundus photographs, fluorescein angiography, and optic coherence tomography [OCT]) and electroretinogram recordings were performed. Histologic evaluation was performed following enucleation at 6 weeks. Results: Intraoperative retinal adhesion occurred in all eyes with ppNIPAM coated parylene and PDMS implants. Two eyes developed retinal tears during the implantation procedure and the ppNIPAM coated implants closed the retinal tears successfully preventing retinal detachment. OCT findings confirmed the retinal adhesion in all eyes. Four weeks after implantation one parylene and one PDMS implant detached partly from the retinal surface. Histology showed mild changes at the outer retinal segments. There was no evidence of ocular toxicity and inflammation. None of the eyes that had an implant covering the retinal tear developed a retinal detachment but had some inflammatory changes around the implants. Conclusions: ppNIPAM coated implants may provide retinal adhesion in vivo without measurable ocular toxicity in the short term. Covering a retinal tear, the ppNIPAM coated implants may prevent retinal detachment. RETINA 28:1338-1343, 2008
Açıklama
WOS: 000260474200025
PubMed: 19430393
PubMed: 19430393
Anahtar Kelimeler
thermosensitive plasma-polymerized N-isopropyl acrylamide, retinal implants, retinal adhesion, rabbit study
Kaynak
Retina-The Journal Of Retinal And Vitreous Diseases
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
28
Sayı
9
