Pregnancy-associated plasma protein-A and asthma

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dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorBalbay, Öner Abidin
dc.contributor.authorDuran, Sadık
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorBulut, İsmet
dc.contributor.authorYavuz, Özlem
dc.contributor.authorKurt, Emel
dc.date.accessioned2020-04-30T23:21:27Z
dc.date.available2020-04-30T23:21:27Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; Annakkaya, Ali Nihat N/0000-0002-7661-8830en_US
dc.descriptionWOS: 000247571900017en_US
dc.descriptionPubMed: 17565927en_US
dc.description.abstractPregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1 +/- 5.0 mU/L) were higher than those of the control group (4.9 +/- 2.1 mU/L) (P <.01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581; P <.01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.en_US
dc.identifier.doi10.1007/BF02849905en_US
dc.identifier.endpage367en_US
dc.identifier.issn0741-238X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://doi.org/10.1007/BF02849905
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4197
dc.identifier.volume24en_US
dc.identifier.wosWOS:000247571900017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHealth Communications Incen_US
dc.relation.ispartofAdvances In Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasthmaen_US
dc.subjectatherosclerosisen_US
dc.subjectIGFen_US
dc.subjectIGFBP-4en_US
dc.subjectPAPP-Aen_US
dc.titlePregnancy-associated plasma protein-A and asthmaen_US
dc.typeArticleen_US

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