Pregnancy-associated plasma protein-A and asthma
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Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Health Communications Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1 +/- 5.0 mU/L) were higher than those of the control group (4.9 +/- 2.1 mU/L) (P <.01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581; P <.01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.
Açıklama
Coskun, Abdurrahman/0000-0002-1273-0604; Annakkaya, Ali Nihat N/0000-0002-7661-8830
WOS: 000247571900017
PubMed: 17565927
WOS: 000247571900017
PubMed: 17565927
Anahtar Kelimeler
asthma, atherosclerosis, IGF, IGFBP-4, PAPP-A
Kaynak
Advances In Therapy
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
24
Sayı
2
