Does L-carnitine have any effect on cold preservation injury of non-fatty liver in the University of Wisconsin solution?

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dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorGünal, Ömer
dc.contributor.authorŞahin, İbrahim
dc.contributor.authorAslaner, Arif
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorYavuz, Özlem
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604;en_US
dc.descriptionWOS: 000248729900010en_US
dc.descriptionPubMed: 17517073en_US
dc.description.abstractAim: To evaluate the protective effect of L-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Methods: Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW Plus L-carnitine group. Retrieved liver grafts were preserved in UW and UW Plus L-carnitine solutions at +4 degrees C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. Results: No micro or macrovacuolar fat droplets were observed in the tissue slices. L-Carnitine effectively decreased enzyme release when added to UW solution (P < 0.05). Conclusion: in addition to fatty liver, L-carnitine might be a metabolic adjunct in preservation solutions for non-fatty liver within UW solution.en_US
dc.identifier.doi10.1111/j.1872-034X.2007.00088.xen_US
dc.identifier.endpage660en_US
dc.identifier.issn1386-6346
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage656en_US
dc.identifier.urihttps://doi.org/10.1111/j.1872-034X.2007.00088.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5613
dc.identifier.volume37en_US
dc.identifier.wosWOS:000248729900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofHepatology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcold ischemiaen_US
dc.subjectL-carnitineen_US
dc.subjectliver preservationen_US
dc.subjecttransplantationen_US
dc.subjectUniversity of Wisconsinen_US
dc.titleDoes L-carnitine have any effect on cold preservation injury of non-fatty liver in the University of Wisconsin solution?en_US
dc.typeArticleen_US

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