Does L-carnitine have any effect on cold preservation injury of non-fatty liver in the University of Wisconsin solution?
Yükleniyor...
Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the protective effect of L-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Methods: Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW Plus L-carnitine group. Retrieved liver grafts were preserved in UW and UW Plus L-carnitine solutions at +4 degrees C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. Results: No micro or macrovacuolar fat droplets were observed in the tissue slices. L-Carnitine effectively decreased enzyme release when added to UW solution (P < 0.05). Conclusion: in addition to fatty liver, L-carnitine might be a metabolic adjunct in preservation solutions for non-fatty liver within UW solution.
Açıklama
Coskun, Abdurrahman/0000-0002-1273-0604;
WOS: 000248729900010
PubMed: 17517073
WOS: 000248729900010
PubMed: 17517073
Anahtar Kelimeler
cold ischemia, L-carnitine, liver preservation, transplantation, University of Wisconsin
Kaynak
Hepatology Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
37
Sayı
8
