Does L-carnitine have any effect on cold preservation injury of non-fatty liver in the University of Wisconsin solution?
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Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Blackwell Publishing
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Aim: To evaluate the protective effect of L-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Methods: Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW Plus L-carnitine group. Retrieved liver grafts were preserved in UW and UW Plus L-carnitine solutions at +4 degrees C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. Results: No micro or macrovacuolar fat droplets were observed in the tissue slices. L-Carnitine effectively decreased enzyme release when added to UW solution (P < 0.05). Conclusion: in addition to fatty liver, L-carnitine might be a metabolic adjunct in preservation solutions for non-fatty liver within UW solution.
Description
Coskun, Abdurrahman/0000-0002-1273-0604;
WOS: 000248729900010
PubMed: 17517073
WOS: 000248729900010
PubMed: 17517073
Keywords
cold ischemia, L-carnitine, liver preservation, transplantation, University of Wisconsin
Journal or Series
Hepatology Research
WoS Q Value
Q3
Scopus Q Value
Q1
Volume
37
Issue
8
