Effect of topical rifamycin application on epidural fibrosis in rats

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dc.contributor.authorDinç, Cem
dc.contributor.authorTuncer, Cengiz
dc.contributor.authorTürkoğlu, Mehmet Erhan
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorOcak, Pınar
dc.contributor.authorEr, Uygur
dc.date.accessioned2020-05-01T09:11:49Z
dc.date.available2020-05-01T09:11:49Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description16th World Congress of Neurosurgery of the World-Federation-of-Neurosurgical-Societies (WFNS) -- AUG 20-25, 2017 -- Istanbul, TURKEYen_US
dc.descriptionEser Ocak, Pinar/0000-0003-0132-9927en_US
dc.descriptionWOS: 000476701900004en_US
dc.descriptionPubMed: 31453541en_US
dc.description.abstractObjectives: This study aims to investigate the effects of topical rifamycin SV application on epidural fibrosis formation in a rat model. Materials and methods: Between March 2015 and April 2015, a total of 20 Wistar rats were equally and randomly divided into laminectomy only group (control group) and laminectomy and rifamycin SV group (treatment group). Laminectomy was performed between L3-L5 in all rats. Surgical field was irrigated with 1 mL rifamycin SV (1 mL). After four weeks, vertebral columns of the rats were removed en bloc between the L1 and L5 levels, and epidural fibrosis and arachnoid involvement were histopathologically evaluated and graded. Results: Grade 3 epidural fibrosis formation ratio was lower in the treatment group (40%) compared to the control group (80%). However, there was no statistically significant difference between the treatment and control groups in terms of epidural fibrosis (p=0.164) and arachnoid involvement (p=0.303). Conclusion: Intraoperative rifamycin irrigation tends to reduce epidural fibrosis formation risk, although not statistically significant.en_US
dc.description.sponsorshipWorld Federat Neurosurg Socen_US
dc.identifier.doi10.5606/tftrd.2019.2442en_US
dc.identifier.endpage29en_US
dc.identifier.issn2587-0823
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.5606/tftrd.2019.2442
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5777
dc.identifier.volume65en_US
dc.identifier.wosWOS:000476701900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Physical Medicine And Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpidural fibrosisen_US
dc.subjectlaminectomyen_US
dc.subjectrifamycinen_US
dc.titleEffect of topical rifamycin application on epidural fibrosis in ratsen_US
dc.typeArticleen_US

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