Investigation of the preventive effect of proanthocyanidin in ischemia-reperfusion injury in lung transplantation: An experimental study

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dc.contributor.authorSapmaz, Ersin
dc.contributor.authorÇaylak, Hasan
dc.contributor.authorKavaklı, Kuthan
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorŞirin, Yusuf Sinan
dc.contributor.authorGenç, Onur
dc.date.accessioned2020-04-30T23:18:42Z
dc.date.available2020-04-30T23:18:42Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionSapmaz, Ersin/0000-0003-1252-2714;en_US
dc.descriptionWOS: 000450917400012en_US
dc.descriptionPubMed: 32082803en_US
dc.description.abstractBackground: This study aims to investigate the preventive effect of proanthocyanidin against ischemia-reperfusion injury after lung transplantation. Methods: The study included 12 swines (weighing 35 +/- 5 kg) and separated into four groups. Groups 1 and 3 were identified as control groups and left upper lobectomy was performed. Groups 2 and 4 were identified as transplantation groups and left lower lobectomy and heterotransplantation were performed. Proanthocyanidin was only given to groups 3 and 4. Tissue samples were analyzed under light microscope and histopathological findings were recorded. Results: There was no statistically significant difference between control groups in terms of the numerical values of histopathological findings that include congestion (p=0.565), alveolar edema (p=0.197) and peribronchial inflammation (p=0.444). However, numerical values of acute cellular rejection were statistically significantly different between transplantation groups (p=0.048). Mean oxidative stress enzyme levels were higher in group 2 compared to group 4; however, the difference was not statistically significant (p>0.05). Conclusion: According to the findings of our experimental study, proanthocyanidin can be safely used in lung transplantation based on its preventive effect in ischemia-reperfusion injury that may lead to morbidity and mortality.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2018.16078en_US
dc.identifier.endpage613en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2018.16078
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3483
dc.identifier.volume26en_US
dc.identifier.wosWOS:000450917400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExperimentalen_US
dc.subjectischemia-reperfusionen_US
dc.subjectlung transplantationen_US
dc.subjectoxidative stressen_US
dc.subjectproanthocyanidinen_US
dc.titleInvestigation of the preventive effect of proanthocyanidin in ischemia-reperfusion injury in lung transplantation: An experimental studyen_US
dc.typeArticleen_US

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