Antileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitro

Basit Öğe Kaydı
dc.contributor.authorAlpay, Merve
dc.contributor.authorDikmen, Begüm Yurdakök
dc.contributor.authorKısmalı, Görkem
dc.contributor.authorSel, Tevhide
dc.date.accessioned2020-04-30T22:39:29Z
dc.date.available2020-04-30T22:39:29Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000382405800020en_US
dc.descriptionPubMed: 27461609en_US
dc.description.abstractAim of Study: This research indicated to evaluate the effects of piperlongumine (PL), a biologically active alkaloid, and alpha lipoic acid (ALA), a naturally occurring cofactor existed in multienzyme complexes regulating metabolism on leukemia cells. Excessive production of reactive oxygen species (ROS) can lead to oxidative stress, a state that has been observed in several hematopoietic malignancies, including acute and chronic myeloid leukemias. The importance of the association between oxidative stress and malignancy is not currently clear; however, there is evidence that tumor.derived ROS may promote cell survival, migration and metastasis, proliferation and even drug.resistance depending on the origin of the cancer. Increased oxidative stress in leukemic cells may represent a potential therapeutic target, although there are differing opinions on whether therapeutic strategies should aim to antagonize or further promote oxidative stress in leukemic cells. Materials and Methods: The effects of PL alone (5, 15, 30 M) and in combination (30 M) with ALA (200 M) on Jurkat, NB4 and MEC1 leukemia cell lines were investigated through MTT, caspase-3 and cyclooxygenase-2 (COX-2) activities. Results: Inhibition of COX-2 and the induction of caspase.3 cleavage in Nb4 (acute promyelocytic leukemia) cells were found to be significant following PL application and synergistic effects with combination of ALA (inhibition of COX-2 as 23.74% and 3.55-fold increase of caspase-3). Conclusion: PL and ALA may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.en_US
dc.identifier.doi10.4103/0973-1482.151936en_US
dc.identifier.endpage560en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage556en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.151936
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2737
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382405800020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectCOX-2en_US
dc.subjectleukemic cell linesen_US
dc.subjectoxidative stressen_US
dc.subjectpiperlongumineen_US
dc.titleAntileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitroen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
2737.pdf
Boyut:
923.27 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu