Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum

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dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorErman, Hayriye
dc.contributor.authorTopuz, Seren
dc.contributor.authorBıyık, İsmail
dc.contributor.authorErkan, Müşerref
dc.date.accessioned2020-05-01T12:10:15Z
dc.date.available2020-05-01T12:10:15Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionUzun, Hafize/0000-0002-1347-8498en_US
dc.descriptionWOS: 000319130800005en_US
dc.descriptionPubMed: 23330872en_US
dc.description.abstractObjective: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). Methods: Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p <= 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p <= 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. Conclusion: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.en_US
dc.identifier.doi10.3109/14767058.2013.766699en_US
dc.identifier.endpage870en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage866en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.766699
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6101
dc.identifier.volume26en_US
dc.identifier.wosWOS:000319130800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjecthyperemesis gravidarumen_US
dc.subjectleptinen_US
dc.subjectPYY-3en_US
dc.titleGhrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarumen_US
dc.typeArticleen_US

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