Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). Methods: Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p <= 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p <= 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. Conclusion: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.
Açıklama
Uzun, Hafize/0000-0002-1347-8498
WOS: 000319130800005
PubMed: 23330872
WOS: 000319130800005
PubMed: 23330872
Anahtar Kelimeler
Ghrelin, hyperemesis gravidarum, leptin, PYY-3
Kaynak
Journal Of Maternal-Fetal & Neonatal Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
26
Sayı
9
