Evaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomas

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dc.contributor.authorHavva, Erdem
dc.contributor.authorFeyza, Basar
dc.contributor.authorNilufer, Kadioglu
dc.contributor.authorMurat, Oktay
dc.contributor.authorHandan, Ankarali
dc.contributor.authorAli, Yavuzcan
dc.contributor.authorSerdar, Dilbaz
dc.contributor.authorErdem, Havva
dc.contributor.authorBaşar, Feyza
dc.contributor.authorKadıoğlu, Nilüfer
dc.contributor.authorMurat, Oktay
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorDilbaz, Serdar
dc.date.accessioned2020-05-01T12:16:41Z
dc.date.available2020-05-01T12:16:41Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000217838200009en_US
dc.descriptionPubMed: 26405405en_US
dc.description.abstractApproximately, one fourth of women have leiomyomas. Leiomyomas are benign tumors that originated from smooth muscle cells. Estrogen is claimed to relate as a cause but exact mechanism has not fully understood. In this study, 95 leiomyoma cases that have been diagnosed by our department in years between 2010 and 2012 were examined. Age ranges of patients, sizes, locations, and numbers of leiomyomas were identified. Immunohistochemically ER (estrogen), PR (progesterone), and Gross cystic disease fluid protein-15 stains were performed to the paraffin blocks and their percentages of staining were noted. Statistically, submucosal and intramural locations were significantly related to ER and PR (p < 0,001). There were significant relationship between ER and PR in 30-50 years age group (p < 0,001). There were significant relationship between ER, PR and locations (p < 0,001), numbers (p < 0,001), sizes of leiomyomas (below 5 cm; p < 0,001), (between 5 and 10 cm; p = 0,037), larger than 10 cm; p = 0,002). Consequently, relationship between leiomyoma and ER, PR were revealed in this study. Also, relationship between leiomyoma locations and patient ages were identified statistically. There was no immunoreactivity with GCDFP-15 in leiomyomas.en_US
dc.identifier.doi10.1007/s13224-014-0617-1en_US
dc.identifier.endpage338en_US
dc.identifier.issn0971-9202
dc.identifier.issn0975-6434
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.1007/s13224-014-0617-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6409
dc.identifier.volume65en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofJournal Of Obstetrics And Gynecology Of Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUterine leiomyomaen_US
dc.subjectERen_US
dc.subjectPRen_US
dc.subjectGCDFP-15en_US
dc.titleEvaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomasen_US
dc.typeArticleen_US

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