Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study

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dc.contributor.authorErdem, Havva
dc.contributor.authorAydın, Hasan Rıza
dc.contributor.authorBahadır, Anzel
dc.contributor.authorGündoğdu, Betül
dc.contributor.authorBalta, Hilal
dc.contributor.authorŞener, Ebru
dc.contributor.authorErdoğan, Fazlı
dc.date.accessioned2020-04-30T23:31:37Z
dc.date.available2020-04-30T23:31:37Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000360441800004en_US
dc.descriptionPubMed: 26060153en_US
dc.description.abstractObjective: To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics. Methods: The study entailed histopathological diagnoses carried out on paraffin blocks at the Department of Pathology of the Medical Hospital of Duzce University, Turkey, between 2005 and 2011. Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95 was performed on tissue microarray using standard procedures. Each patient's age and gender as well as the tumour's grade, stage, diameter, ureteral surgical margins, vascular invasion, capsule invasion and subtype were assessed. In order to determine if the cases were still alive, relatives were telephoned and identity registration records were checked. SPSS 18 was used for statistical analysis. Results: There were 49 paraffin blocks in the study. Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026). There was a significant correlation between cluster of differentiation 95 and the Fuhrman grade (p=0.050). Conclusion: Expression of cluster of differentiation 95 and cyclooxygenase-2 may be correlated with prognostic parameters in renal cell carcinoma and may also be associated with tumour progression.en_US
dc.identifier.endpage601en_US
dc.identifier.issn0030-9982
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4363
dc.identifier.volume65en_US
dc.identifier.wosWOS:000360441800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal Of The Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD95en_US
dc.subjectCyclooxygenase-2en_US
dc.subjectCOX-2en_US
dc.subjectPrognosisen_US
dc.subjectRenal cell carcinomasen_US
dc.titleRelationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray studyen_US
dc.typeArticleen_US

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