Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pakistan Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics. Methods: The study entailed histopathological diagnoses carried out on paraffin blocks at the Department of Pathology of the Medical Hospital of Duzce University, Turkey, between 2005 and 2011. Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95 was performed on tissue microarray using standard procedures. Each patient's age and gender as well as the tumour's grade, stage, diameter, ureteral surgical margins, vascular invasion, capsule invasion and subtype were assessed. In order to determine if the cases were still alive, relatives were telephoned and identity registration records were checked. SPSS 18 was used for statistical analysis. Results: There were 49 paraffin blocks in the study. Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026). There was a significant correlation between cluster of differentiation 95 and the Fuhrman grade (p=0.050). Conclusion: Expression of cluster of differentiation 95 and cyclooxygenase-2 may be correlated with prognostic parameters in renal cell carcinoma and may also be associated with tumour progression.
Açıklama
WOS: 000360441800004
PubMed: 26060153
PubMed: 26060153
Anahtar Kelimeler
CD95, Cyclooxygenase-2, COX-2, Prognosis, Renal cell carcinomas
Kaynak
Journal Of The Pakistan Medical Association
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
65
Sayı
6
