Genetic origin of Behcet's disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on beta-globin gene cluster haplotype variation

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dc.contributor.authorÖztürk, Onur
dc.contributor.authorArıkan, Sanem
dc.contributor.authorBahadır, Anzel
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorAtalay, Erol Ö.
dc.date.accessioned2020-05-01T12:10:12Z
dc.date.available2020-05-01T12:10:12Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionOzturk, Onur/0000-0003-3404-4135en_US
dc.descriptionWOS: 000393734600005en_US
dc.descriptionPubMed: 28031553en_US
dc.description.abstractIn our study, we aimed to investigate the possible genetic drift, relationships, expansion and historical origin based on haplotype frequencies of the beta-globin gene cluster of normal and Behcet's disease (BD) population in Denizli, Turkey. We examined blood DNA samples obtained from our DNA bank. The association of population genetic parameters such as haplotypes, diversity, differentiation, Hardy Weinberg equilibrium and demographic analysis for two populations was performed by Arlequin ver. 3.5. Our results show that both populations have high similarity in genetic parameters in terms of development and expansion based on haplotype diversity through the history. We found that historical levels of gene flow were significantly higher between the two populations. According to historical population, growth parameter of tau values for normal and BD populations dated approximately 42 000 to 38 000 ybp, respectively. In conclusion, historically, two populations show similar genetic parameters and unimodal growth distribution. Our results are consistent with the view that the BD may have occurred in area, independent from Silk Road.en_US
dc.description.sponsorshipPamukkale UniversityPamukkale University [2005SBE001, 2005SBE002, 2006SBE004]en_US
dc.description.sponsorshipThis work was partially supported by Pamukkale University Research Fund Projects Nos 2005SBE001,2005SBE002 and 2006SBE004 regarding to consumables used.en_US
dc.identifier.doi10.1038/gene.2016.46en_US
dc.identifier.endpage32en_US
dc.identifier.issn1466-4879
dc.identifier.issn1476-5470
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.1038/gene.2016.46
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6072
dc.identifier.volume18en_US
dc.identifier.wosWOS:000393734600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofGenes And Immunityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleGenetic origin of Behcet's disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on beta-globin gene cluster haplotype variationen_US
dc.typeArticleen_US

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