Genetic origin of Behcet's disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on beta-globin gene cluster haplotype variation
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Publishing Group
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In our study, we aimed to investigate the possible genetic drift, relationships, expansion and historical origin based on haplotype frequencies of the beta-globin gene cluster of normal and Behcet's disease (BD) population in Denizli, Turkey. We examined blood DNA samples obtained from our DNA bank. The association of population genetic parameters such as haplotypes, diversity, differentiation, Hardy Weinberg equilibrium and demographic analysis for two populations was performed by Arlequin ver. 3.5. Our results show that both populations have high similarity in genetic parameters in terms of development and expansion based on haplotype diversity through the history. We found that historical levels of gene flow were significantly higher between the two populations. According to historical population, growth parameter of tau values for normal and BD populations dated approximately 42 000 to 38 000 ybp, respectively. In conclusion, historically, two populations show similar genetic parameters and unimodal growth distribution. Our results are consistent with the view that the BD may have occurred in area, independent from Silk Road.
Açıklama
Ozturk, Onur/0000-0003-3404-4135
WOS: 000393734600005
PubMed: 28031553
WOS: 000393734600005
PubMed: 28031553
Anahtar Kelimeler
Kaynak
Genes And Immunity
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
18
Sayı
1
