Protein oxidation markers in women with and without gestational diabetes mellitus: A possible relation with paraoxonase activity

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dc.contributor.authorGelişgen, Remise
dc.contributor.authorGenç, Habibe
dc.contributor.authorKayalı, Refik
dc.contributor.authorÖncül, Mahmut
dc.contributor.authorBenian, Ali
dc.contributor.authorGüralp, Onur
dc.contributor.authorUzun, Hafize
dc.date.accessioned2020-04-30T23:31:31Z
dc.date.available2020-04-30T23:31:31Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionUzun, Hafize/0000-0002-1347-8498; Gelisgen, Remise/0000-0003-4121-5107; Cakatay, Ufuk/0000-0001-9861-7380; Guralp, Onur/0000-0002-3517-3046en_US
dc.descriptionWOS: 000298144400021en_US
dc.descriptionPubMed: 21885148en_US
dc.description.abstractAims: To clarify the levels of protein oxidation markers such as protein carbonyl (PCO), protein hydroperoxides (P-OOH), advanced oxidation protein products (AOPP) and nitrotyrosine (NT), as well as antioxidative enzymes such as paraoxonase (PON-1) in women with and without gestational diabetes mellitus (GDM). Methods: The study was conducted on 23 women with GDM and 22 women without GDM. The levels of the P-OOH, AOPP, and PON-1 were determined by colorimetric methods; whereas NT and PCO levels were measured by ELISA. Results: The concentrations of protein oxidation markers were significantly increased and PON1 activity was significantly decreased in GDM group compared to those of normal pregnant women. The control group showed a significant negative correlation between PON-1 and PCO (r = -0.451, p = 0.027); whereas in GDM group, there was a significant positive correlation between P-OOH and HbA1c (r = 0.89, p = 0.001). There was no significant correlation between AOPP, PON-1, P-OOH, PCO, and HbA1c in either group. Conclusions: There is evidence of a possible association between protein oxidation and decreased PON1 activity in GDM. The increase in protein oxidation parameters in the GDM group leading to decreased PON1 activity might, we think, create a predisposition for clinical complications in GDM group. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipIstanbul UniversityIstanbul University [BYP-871/23122005]en_US
dc.description.sponsorshipThis work was supported by The Research Fund of Istanbul University (Project number: BYP-871/23122005).en_US
dc.identifier.doi10.1016/j.diabres.2011.08.001en_US
dc.identifier.endpage409en_US
dc.identifier.issn0168-8227
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage404en_US
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2011.08.001
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4265
dc.identifier.volume94en_US
dc.identifier.wosWOS:000298144400021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDiabetes Research And Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational diabetesen_US
dc.subjectProtein carbonylen_US
dc.subjectParaoxonaseen_US
dc.subjectProtein hydroperoxidesen_US
dc.subjectNitrotyrosineen_US
dc.titleProtein oxidation markers in women with and without gestational diabetes mellitus: A possible relation with paraoxonase activityen_US
dc.typeArticleen_US

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