Protein oxidation markers in women with and without gestational diabetes mellitus: A possible relation with paraoxonase activity
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aims: To clarify the levels of protein oxidation markers such as protein carbonyl (PCO), protein hydroperoxides (P-OOH), advanced oxidation protein products (AOPP) and nitrotyrosine (NT), as well as antioxidative enzymes such as paraoxonase (PON-1) in women with and without gestational diabetes mellitus (GDM). Methods: The study was conducted on 23 women with GDM and 22 women without GDM. The levels of the P-OOH, AOPP, and PON-1 were determined by colorimetric methods; whereas NT and PCO levels were measured by ELISA. Results: The concentrations of protein oxidation markers were significantly increased and PON1 activity was significantly decreased in GDM group compared to those of normal pregnant women. The control group showed a significant negative correlation between PON-1 and PCO (r = -0.451, p = 0.027); whereas in GDM group, there was a significant positive correlation between P-OOH and HbA1c (r = 0.89, p = 0.001). There was no significant correlation between AOPP, PON-1, P-OOH, PCO, and HbA1c in either group. Conclusions: There is evidence of a possible association between protein oxidation and decreased PON1 activity in GDM. The increase in protein oxidation parameters in the GDM group leading to decreased PON1 activity might, we think, create a predisposition for clinical complications in GDM group. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Uzun, Hafize/0000-0002-1347-8498; Gelisgen, Remise/0000-0003-4121-5107; Cakatay, Ufuk/0000-0001-9861-7380; Guralp, Onur/0000-0002-3517-3046
WOS: 000298144400021
PubMed: 21885148
WOS: 000298144400021
PubMed: 21885148
Anahtar Kelimeler
Gestational diabetes, Protein carbonyl, Paraoxonase, Protein hydroperoxides, Nitrotyrosine
Kaynak
Diabetes Research And Clinical Practice
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
94
Sayı
3
