Prenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological study

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dc.contributor.authorCanan, Sinan
dc.contributor.authorAktaş, Abit
dc.contributor.authorUlkay, Muzaffer Başak
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorRağbetli, Murat Çetin
dc.contributor.authorAyyıldız, Mustafa
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2020-04-30T23:21:30Z
dc.date.available2020-04-30T23:21:30Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKaplan, Suleyman/0000-0003-1477-5002; AYYILDIZ, Mustafa/0000-0002-6594-3080; ulkay, muzaffer basak/0000-0002-0928-0462; Geuna, Stefano/0000-0002-6962-831X; Canan, Sinan/0000-0002-9864-1767en_US
dc.descriptionWOS: 000260953300011en_US
dc.descriptionPubMed: 18678241en_US
dc.description.abstractThe toxic effect of non-steroidal anti-inflammatory drugs (NSAIDs) during development has been widely investigated. While it has been shown that these drugs impair central nervous development and compromise the neural activity, the effects of these substances on the development of peripheral nerves are still not clarified. In the present Study, sciatic nerves withdrawn from three experimental groups of 4-week-old rats, prenatally exposed to either saline solution, or cliclofenac sodium, and controls not exposed to any substance, were evaluated in terms of axon number, cross-sectional area of axon and myelin sheet thickness as well as of the ultrastructure of nerve fibers. Comparisons of stereological estimations among these three groups showed that axon number and mean axon cross-sectional area, but not average myelin sheet thickness, were significantly decreased in rats that were exposed to both diclofenac sodium and also to the saline solution, in comparison of the control group. Electron microscope analysis revealed, in both treated groups, deterioration of myelin sheaths that was more pronounced in rats that were exposed to cliclofenac sodium. Altogether, these findings show that the prenatal administration of both diclofenac sodium and saline solution impairs peripheral nervous system development, thus suggesting that this potential teratogenic effect should be also taken into consideration in the clinical use of these substances in pregnant patients. (C) 2008 ISDN. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijdevneu.2008.07.005en_US
dc.identifier.endpage738en_US
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijdevneu.2008.07.005
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4203
dc.identifier.volume26en_US
dc.identifier.wosWOS:000260953300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofInternational Journal Of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSciatic nerveen_US
dc.subjectAxon numberen_US
dc.subjectDiclofenac sodiumen_US
dc.subjectStereologyen_US
dc.subjectRaten_US
dc.titlePrenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological studyen_US
dc.typeArticleen_US

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