Prenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological study
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The toxic effect of non-steroidal anti-inflammatory drugs (NSAIDs) during development has been widely investigated. While it has been shown that these drugs impair central nervous development and compromise the neural activity, the effects of these substances on the development of peripheral nerves are still not clarified. In the present Study, sciatic nerves withdrawn from three experimental groups of 4-week-old rats, prenatally exposed to either saline solution, or cliclofenac sodium, and controls not exposed to any substance, were evaluated in terms of axon number, cross-sectional area of axon and myelin sheet thickness as well as of the ultrastructure of nerve fibers. Comparisons of stereological estimations among these three groups showed that axon number and mean axon cross-sectional area, but not average myelin sheet thickness, were significantly decreased in rats that were exposed to both diclofenac sodium and also to the saline solution, in comparison of the control group. Electron microscope analysis revealed, in both treated groups, deterioration of myelin sheaths that was more pronounced in rats that were exposed to cliclofenac sodium. Altogether, these findings show that the prenatal administration of both diclofenac sodium and saline solution impairs peripheral nervous system development, thus suggesting that this potential teratogenic effect should be also taken into consideration in the clinical use of these substances in pregnant patients. (C) 2008 ISDN. Published by Elsevier Ltd. All rights reserved.
Açıklama
Kaplan, Suleyman/0000-0003-1477-5002; AYYILDIZ, Mustafa/0000-0002-6594-3080; ulkay, muzaffer basak/0000-0002-0928-0462; Geuna, Stefano/0000-0002-6962-831X; Canan, Sinan/0000-0002-9864-1767
WOS: 000260953300011
PubMed: 18678241
WOS: 000260953300011
PubMed: 18678241
Anahtar Kelimeler
Sciatic nerve, Axon number, Diclofenac sodium, Stereology, Rat
Kaynak
International Journal Of Developmental Neuroscience
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
26
Sayı
7
