Electrochemical treatment of anti-cancer drug carboplatin on mixed-metal oxides and boron doped diamond electrodes: Density functional theory modelling and toxicity evaluation

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dc.contributor.authorBarışçı, Sibel
dc.contributor.authorTürkay, Özge
dc.contributor.authorUlusoy, Ebru
dc.contributor.authorSoydemir, Gülfem
dc.contributor.authorŞeker, Mine Gül
dc.contributor.authorDimoglo, Anatoli
dc.date.accessioned2020-05-01T09:12:13Z
dc.date.available2020-05-01T09:12:13Z
dc.date.issued2018
dc.departmentDÜ, Orman Fakültesi, Orman Endüstrisi Mühendisliği Bölümüen_US
dc.descriptionBarisci, Sibel/0000-0003-4229-0408; Dinc, Ozge/0000-0002-3029-7840;en_US
dc.descriptionWOS: 000423246700032en_US
dc.descriptionPubMed: 29078184en_US
dc.description.abstractThis study represents the electrooxidation of anti-cancer drug carboplatin (CrbPt) with different mixed metal oxide (MMO) and boron doped diamond (BDD) electrodes. The most effective anode was found as Ti/RuO2 with the complete degradation of CrbPt in just 5 min. The effect of applied current density, pH and electrolyte concentration on CrbPt degradation has been studied. The degradation of CrbPt significantly increased at the initial stages of the process with increasing current density. However, further increase in current density did not affect the degradation rate. While complete degradation of CrbPt was provided at pH 7, the degradation rates were 49% and 75% at pH 9 and 4, respectively. Besides, increasing supporting electrolyte (Na2SO4) concentration provided higher degradation rate but further increase in Na2SO4 concentration did not provide higher degradation rate due to excess amount of SO4-2 According to the DFT calculations, the formation of [Pt(NH3)(2) (H2O)(2)](2+) and [Pt(NH3)(2) (OH)(2)] takes place with molecular weights of 265 and 263 gmol(-1), respectively. Toxicity of treated samples at BDD and Ti/RuO2 electrodes has been also evaluated in this study. The results showed that Ti/RuO2 anode provided zero toxicity at the end of the process. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Y606]en_US
dc.description.sponsorshipFinancial support received from TUBITAK (The Scientific and Technological Research Council of Turkey) under project 114Y606 is acknowledged.en_US
dc.identifier.doi10.1016/j.jhazmat.2017.10.029en_US
dc.identifier.endpage321en_US
dc.identifier.issn0304-3894
dc.identifier.issn1873-3336
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.1016/j.jhazmat.2017.10.029
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5911
dc.identifier.volume344en_US
dc.identifier.wosWOS:000423246700032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Hazardous Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarboplatinen_US
dc.subjectMixed metal oxideen_US
dc.subjectBoron doped diamonden_US
dc.subjectDensity functional theoryen_US
dc.subjectToxicityen_US
dc.titleElectrochemical treatment of anti-cancer drug carboplatin on mixed-metal oxides and boron doped diamond electrodes: Density functional theory modelling and toxicity evaluationen_US
dc.typeArticleen_US

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