Electrochemical treatment of anti-cancer drug carboplatin on mixed-metal oxides and boron doped diamond electrodes: Density functional theory modelling and toxicity evaluation
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study represents the electrooxidation of anti-cancer drug carboplatin (CrbPt) with different mixed metal oxide (MMO) and boron doped diamond (BDD) electrodes. The most effective anode was found as Ti/RuO2 with the complete degradation of CrbPt in just 5 min. The effect of applied current density, pH and electrolyte concentration on CrbPt degradation has been studied. The degradation of CrbPt significantly increased at the initial stages of the process with increasing current density. However, further increase in current density did not affect the degradation rate. While complete degradation of CrbPt was provided at pH 7, the degradation rates were 49% and 75% at pH 9 and 4, respectively. Besides, increasing supporting electrolyte (Na2SO4) concentration provided higher degradation rate but further increase in Na2SO4 concentration did not provide higher degradation rate due to excess amount of SO4-2 According to the DFT calculations, the formation of [Pt(NH3)(2) (H2O)(2)](2+) and [Pt(NH3)(2) (OH)(2)] takes place with molecular weights of 265 and 263 gmol(-1), respectively. Toxicity of treated samples at BDD and Ti/RuO2 electrodes has been also evaluated in this study. The results showed that Ti/RuO2 anode provided zero toxicity at the end of the process. (C) 2017 Elsevier B.V. All rights reserved.
Açıklama
Barisci, Sibel/0000-0003-4229-0408; Dinc, Ozge/0000-0002-3029-7840;
WOS: 000423246700032
PubMed: 29078184
WOS: 000423246700032
PubMed: 29078184
Anahtar Kelimeler
Carboplatin, Mixed metal oxide, Boron doped diamond, Density functional theory, Toxicity
Kaynak
Journal Of Hazardous Materials
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
344
