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Öğe Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury(Turkish Assoc Trauma Emergency Surgery, 2007) Sanus, Galip Zihni; Tanrıverdi, Taner; Coşkun, Abdurrahman; Hanımoğlu, Hakan; İş, Merih; Uzan, MustafaBACKGROUND The aim of this study is to present time course of insulin like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in both cerebrospinal fluid (CSF) and serum of patients after severe head injury (SHI) and to compare with controls. METHODS Our trauma and control groups included 11 consecutive patients with isolated SHI and 9 patients with hydrocephalus (one with normotensive and eight with hydrocephalus due to aqueduct stenosis), respectively. Both serum and cerebrospinal fluid levels of IGF-1 and IGFBP-3 were measured during post-traumatic days and we compared the levels with controls. RESULTS Patients and controls showed undetectable levels of both IGF-1 and IGFBP-3 in their CSF. When considering serum levels, patients with SHI had always lower levels of both molecules than that of controls. CONCLUSION Administration of IGF-1 during acute, as well as chronic phase of severe head trauma may provide beneficial effects and may decrease both mortality and morbidity in humans with SHI.Öğe Comparison of Gliclazide Treatment with Diet Therapy on Acute Phase Protein Levels in Patients with Type 2 Diabetes(Tubitak Scientific & Technical Research Council Turkey, 2009) Memişoğulları, Ramazan; Akçay, Fatih; Coşkun, Abdurrahman; Korkmaz, UğurAims: It is known that there is a relationship between diabetic complications and chronic inflammation characterized by alterations in circulating acute phase proteins. It has been emphasized that inflammation contributes to diabetic complications and that gliclazide -an antidiabetic sulfonylurea - decreases the development of such complications. In this study, we aimed to investigate whether gliclazide or diet treatment has an effect on serum levels of acute phase reactants. markers of inflammation. Materials and Methods: Fifty-six newly diagnosed patients with type 2 diabetes and 30 clinically healthy subjects were evaluated prospectively. Twenty-six patients were treated with proper diet and daily gliclazide (80 mg/daily) and 30 patients were randomized to only diet therapy for 6 months. After the 6-month therapy, blood was taken from patients and controls and acute phase protein levels were determined. Results: Serum alpha-1 acid glycoprotein. alpha-2 macroglobulin, alpha-1 antitrypsin. and albumin levels did not differ between the gliclazide and control groups. In the diet group. mean serum alpha-1 acid glycoprotein, alpha-2 macroglobulin, and alpha-1 antitrypsin were significantly higher and mean albumin level was significantly lower than the other groups. Glucose, hemoglobin A1C and haptoglobulin levels were significantly higher, whereas transferrin and prealbumin levels were significantly lower in both diet therapy and gliclazide therapy when compared with the control group. Mean C-reactive protein level did not differ between the groups. Conclusions: Levels of acute phase proteins significantly differ in type 2 diabetes when compared with healthy subjects. Gliclazide may provide better control on acute phase proteins.Öğe Comparison of Serum CA 19.9, CA 125 and CEA Levels with Severity of Chronic Obstructive Pulmonary Disease(Karger, 2009) Bulut, İsmet; Arbak, Peri Meram; Coşkun, Abdurrahman; Balbay, Öner Abidin; Annakkaya, Ali Nihat; Yavuz, Özlem; Gülcan, ErimObjective: To investigate serum levels of CA 19.9, CA 125 and carcinoembryonic antigen (CEA) in patients with different stages of chronic obstructive pulmonary disease (COPD). Patients and Methods: Fifty-three consecutive patients (50 males, 3 females, mean age 67.6 +/- 10.1 years) with COPD were included in this study. Serum levels of CA 19.9, CA 25 and CEA were determined by the chemiluminescent immunometric method. Based on values obtained from pulmonary function tests, the patients were divided into 3 groups: moderate (21), severe (18) and very severe (14). Data were analyzed with a Kruskal-Wallis one-way analysis of variance test and Mann-Whitney U test. Results: The mean serum levels of CA 125 and CA 19.9 were significantly higher in patients with very severe COPD (p = 0.013 and p = 0.017, respectively) than in patients with severe and moderate COPD (p < 0.05). Patients with cor pulmonale had significantly high mean serum levels of CEA, CA 19.9 and CA 125 (p < 0.05). Patients using a long-acting beta-agonist and theophylline showed significantly higher mean serum levels of CA 125 than patients who were not (p < 0.05). Conclusion: Data showed that the increased serum tumor markers in patients with COPD might be due to the severity of COPD, medication and cor pulmonale. Copyright (c) 2009 S. Karger AG, BaselÖğe Do Turkish adults really have lower serum levels of high-density lipoprotein cholesterol?(Acta Cardiologica, 2007) Duran, Sadık; Memişoğulları, Ramazan; Coşkun, Abdurrahman; Yavuz, Özlem; Yüksel, HaticeBackground - Coronary heart disease is the leading cause of death in Turkey.The Turkish Heart Study and TEKHARF study have been carried out at various times and in different parts of Turkey and have suggested that the Turkish population has a low high-density lipoprotein-cholesterol (HDLC) level. However, in our daily practice, mean HDL-C levels were not as low as previously reported. Here, we investigated the lipid profile, especially the HDL-C level, in the population of the Duzce region of northwest Turkey. Methods - Serum triglyceride, total cholesterol, and HDL-C levels were measured in 674 healthy volunteers (398 women and 276 men); low-density lipoprotein cholesterol (LDL-C) levels were calculated using the Frieclewald equation. Results - The mean serum HDL-C level was 46.1 +/- 9.8 mg/dl in men and 53.2 +/- 10.7 mg/dl in women; these values are higher than expected based on the Turkish Heart Study. The mean serum total cholesterol level was 196.7 +/- 43.2 mg/dL in men and 198.4 +/- 43.9 mg/dL in women; the mean LDL-C level was 119.6 +/- 34.9 mg/dL in men and 118.7 +/- 34.1 mg/dL in women; and the mean serum triglycericle level was 151.4 +/- 80.9 mg/dL in men and 132.1 +/- 68.9 mg/dL in women. Conclusions - Our finding that the HDL-C level in this population was higher than the previously reported levels in Turkey indicates that HDL-C levels may not be as low as previously thought.We believe that lower HDL-C levels that were previously reported might be due to the difference between techniques of analysis, nutritional status, and percent of subjects who were fasting in the day of analysis or improper subject inclusion which did not reflect the Turkish population causing selection bias.Öğe Does L-carnitine have any effect on cold preservation injury of non-fatty liver in the University of Wisconsin solution?(Blackwell Publishing, 2007) Coşkun, Abdurrahman; Günal, Ömer; Şahin, İbrahim; Aslaner, Arif; Yıldırım, Ümran; Yavuz, ÖzlemAim: To evaluate the protective effect of L-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Methods: Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW Plus L-carnitine group. Retrieved liver grafts were preserved in UW and UW Plus L-carnitine solutions at +4 degrees C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. Results: No micro or macrovacuolar fat droplets were observed in the tissue slices. L-Carnitine effectively decreased enzyme release when added to UW solution (P < 0.05). Conclusion: in addition to fatty liver, L-carnitine might be a metabolic adjunct in preservation solutions for non-fatty liver within UW solution.Öğe Does L-carnitine increase serum TNF -? and IGF-1 during liver regeneration in the rat?(2009) Pehlivan, Mevlüt; Coşkun, Abdurrahman; Zengin, Ahmet; Aslaner, Arif; Yavuz, TevfikAmaç: Rat deneysel parsiyel hepatektomi modelinde L-karnitin uygulamasının 72. saate kadar IGF- 1, TNF ? ve lipid peroksidasyonuna etkisini araştırmayı amaçladık. Yöntem ve gereç: Atmış rat kontrol, düşük (100 mg/kg) ve yüksek doz (200 mg/kg) L-karnitin olmak üzere 3 gruba ayrıldı. Her bir grup, parsiyel hepatektomiden sonra 24 ve 72. saat olmak üzere 2 alt gruba ayrıldı. Yedi gün intra-peritoneal L-karnitin uygulamasından sonra parsiyel (% 70) hepatektomi yapıldı. L-karnitin, parsiyel hepatektomiden sonra da ratlara verilmeye devam edildi. Tüm gruplarda cerrahi operasyondan önce, 24 ve 72 saat sonra serum IGF-1, TNF-? ve doku malondialdehid düzeyleri ölçüldü. Bulgular: Kontrol grubunda, serum TNF-? düzeyleri, rejenerasyon boyunca anlamlı derecede arttı. Düşük doz (100 mg/kg) L-karnitin, TNF-? düzeylerini azaltırken yüksek doz (200 mg/kg) artırdı. IGF-1 düzeyi, kontrol grubunda cerrahi operasyondan sonra ilk 24 saate azalırken daha sonra artmaya başladı. L-karnitin gruplarında IGF-1 düzeylerinde benzer değişimler gözlendi. Malondialdehid düzeyleri kontrol grubunda ilk 24 saatte artarken daha sonra azalmaya başladı. Benzer şekilde L-karnitin gruplarında malondialdehid düzeyleri ilk 24 saatte artarken daha sonra doza bağımlı olarak azaldı. Sonuç: Karaciğer rejenerasyonunda sitokinler, büyüme faktörleri ve metabolik yollar olmak üzere üç temel unsur bulunmaktadır. Enerji metabolizmasındaki etkilerine ilaveten, yüksek doz L-karnitinin, IGF-1, TNF-? düzeyini artırarak ve malondialdehid düzeyini de azaltarak karaciğer rejenerasyonunu hızlandırabileceğini düşünmekteyiz.Öğe Does L-carnitine increase serum TNF -alpha and IGF-1 during liver regeneration in the rat?(Tubitak Scientific & Technical Research Council Turkey, 2009) Pehlivan, Mevlüt; Coşkun, Abdurrahman; Zengin, Ahmet; Aslaner, Arif; Yavuz, TevfikAim: We sought to evaluate the effect of L-carnitine administration on the levels of IGF-1, TNF-alpha, and lipid peroxidation during hepatic regeneration for up to 72 h in an experimental partial hepatic resection rat model. Materials and methods: Sixty rats were divided into 3 groups: control and low-dose (100 mg/kg) and high-close (200 mg/kg) L-carnitine. Each group was divided into 2 sub groups (24 and 72 h after partial hepatectomy). Partial (70%) hepatectomy was performed after 7 days of intra-peritoneal administration of L-carnitine. After partial hepatectomy, L-carnitine was also administered to rats until sacrifice. Serum IGF-1, TNF-alpha, and tissue inalondialdehyde levels were determined in all groups before and at 24 and 72 h after surgery. Results: Serum TNF-alpha increased significantly in the control group during the regeneration period. The low close of L-carnitine (100 mg/kg) decreased the elevation of TNF-alpha whereas the high dose (200 mg/kg) increased it. In the control group, the IGF-1 level decreased in the first 24 h after surgery and then increased. The IGF-1 level behaved similarly in the L-carnitine groups. The inalondialdehyde level in the control group increased during the first 24 h and then decreased. Similarly in the L-carnitine groups, the malondialdehyde level increased during the first 24 h and then decreased significantly in a close-dependent manner. Conclusion: Three types of biochemical pathways are essential in liver regeneration: cytokine, growth factor, and metabolic pathways. We conclude that, in addition to its effects on energy metabolism, high-dose L-carnitine may promote liver regeneration by increasing IGF-1, TNF-alpha, and decreasing malondialdehyde.Öğe Does melatonin alleviate cold preservation injury of the liver?(Tubitak Scientific & Technical Research Council Turkey, 2010) Günal, Ömer; Coşkun, Abdurrahman; Aslaner, Arif; Yıldırım, ÜmranAim: To investigate the effect of melatonin added to preservation solution on liver cold ischemia Materials and methods: Twenty male Wistar albino rats were divided equally into groups treated with University of Wisconsin (UW) solution with and without melatonin The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h Tissue malondialdehyde and heat shock protein (HSP 70) levels were also measured and a histological examination was performed at 48 h Results: Melatonin prevented enzyme elevation, induced heat shock protein (HSP 70), and decreased lipid peroxidation effectively in comparison to the control group (P < 0.05) The histological examination revealed that UW solution containing melatonin prevented Kupffer cell activation and inflammation significantly (P < 0.05) Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 hÖğe Does pregnancy-associated plasma protein A have a role in allergic rhinitis?(Ocean Side Publications Inc, 2008) Güçlü, Ender; Coşkun, Abdurrahman; Tokmak, Abdurrahman; Duran, Sadık; Öztürk, Özcan; Akkan, Nermin; Egeli, ErolBackground: Pregnancy-associated plasma protein A (PAPP-A), also known as insulin-like growth factor binding protein 4 protease, is postulated to be a new inflammatory marker in various clinical situations such as cardiovascular events, dialysis, renal transplantation, and asthma. PAPP-A also is produced in high concentrations by trophoblasts during pregnancy. Methods: We evaluated PAPP-A levels in allergic rhinitis patients and compared these with levels in healthy subjects. Thirty-one newly diagnosed allergic rhinitis patients and 29 healthy controls were included in the study. Serum PAPP-A, IgE, urea, creatinine, aspartate aminotransferase, creatine kinase (CK), CK-MB isoenzyme, total cholesterol, and triglyceride levels were determined. Results: The serum PAPP-A level was significantly higher (p = 0.013) in the allergic rhinitis group (6.1 +/- 2.9 mU/L) than in the control group (4.5 +/- 1.7 mU/L). The PAPP-A level in patients with allergic rhinitis and asthma (6.1 +/- 2.3 mU/L) was not significantly different (p = 0.959) from that in patients with allergic rhinitis alone (6.1 +/- 3.3 mU/L). The serum PAPP-A level in allergic rhinitis patients who had turbinate hypertrophy (6.9 +/- 2.2 mU/L) had a tendency to be higher than that in patients who had no turbinate hypertrophy (5.5 +/- 3.2 mU/L); however, this difference was not statistically significant (p = 0.151). Conclusion: Increased PAPP-A activity may be involved in the inflammation and tissue remodelling that occurs in allergic rhinitis.Öğe The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause(Taylor & Francis Ltd, 2008) Somunkıran, Aslı; Coşkun, Abdurrahman; Demirci, Fuat; Yücel, OğuzThe aim of the present prospective controlled study was to examine the influence of 17 beta-estradiol and tibolone on tumor necrosis factor-alpha (TNF-alpha) levels in healthy women with surgical menopause. Forty-five surgically menopausal women were included in the study. Thirty women were randomized to receive tibolone 2.5 mg or 17 beta-estradiol 2 mg daily for 16 weeks. Fifteen surgically menopausal women who refused hormone therapy served as controls. Serum was collected from the subjects at baseline and at the end of the study for TNF-alpha assay. Neither tibolone nor 17 beta-estradiol showed a significant influence on TNF-alpha level at the end of 16 weeks in comparison with baseline. Although tibolone induced a trend toward decreased level of TNF-alpha (3.30 +/- 0.42 vs. 2.56 +/- 1.94 mu g/dl), this was non-significant. The slight increase observed in TNF-alpha level in the control group was also insignificant (3.60 +/- 1.20 vs. 4.10 +/- 0.70 mu g/dl). Overall, these results demonstrate no significant effects of either tibolone or 17 beta-estradiol on circulating TNF-alpha level in surgically menopausal women. However, the significant difference achieved between the tibolone and control group after treatment is promising and needs to be investigated in trials with longer treatment periods.Öğe Evaluation of tumor markers in asthma patients(2006) Coşkun, Abdurrahman; Balbay, Öner Abidin; Yavuz, Özlem; Memişoğulları, Ramazan; Annakkaya, Ali Nihat; Bulut, İsmet; Kurt, EmelAmaç: Tümör belirteçleri malignitelerin relapsının erken tespitinde ve tedaviye cevabın izlenmesinde biyobelirteçler olarak kullanılmasına rağmen, çoğu tümör belirtecinin kanser tanısında kullanmak için yeterince spesifik olmadığı bilinmektedir. Biz bu çalışmada astımlı hastalarda serum AFP, CEA, CA 19-9, CA 125, CA 15- 3 ve IgE düzeylerini araştırmayı amaçladık. Yöntem ve Gereç: Bu çalışmaya 35 yeni tanı konulmuş astım hastası ve 14 sağlıklı birey dahil edildi. Astımlı ve kontrol bireylerinin antekübital venlerinden kan örnekleri alındı. Otomatik hormon analizöründe, serum AFP, CEA, CA 125, CA 15-3 ve CA 19-9 düzeyleri kemiluminesans, IgE düzeyleri de elektrokemilüminesans immünometrik metodla ölçüldü. Bulgular: Astım hastalarının serum AFP, CEA, CA 125, CA 15-3 ve CA 19-9 düzeyleri kontrol grubundan istatistiksel olarak farklı değildi. Astım hastaları grubunda IgE ile CA 125 arasında negatif (r -0,401; p 0,017) ve CA 125 ile CA 15-3 arasında ise anlamlı pozitif korelasyon olduğu gözlendi (r 0,368; p 0,029). Sonuç: Astım hastalarının serumlarında AFP, CEA, CA 125, CA 19-9 ve CA 15-3 düzeyleri kontrol grubundan farklı olmadığı sonucuna vardık. Astımlı hastalarda bu tümör belirteçlerindeki herhangi bir yükseklikliğin tespit edilmesi durumunda klinisyenlerin, astımdan başka ilave hastalıklarıda göz önünde bulundurmaları gerektiğini düşünmekteyiz.Öğe High serum homocysteine levels correlate with a decrease in the blood flow velocity of the ophthalmic artery in highway toll collectors(Tohoku Univ Medical Press, 2007) Memişoğulları, Ramazan; Yüksel, Harun; Coşkun, Abdurrahman; Yüksel, Hatice Kurt; Yazgan, Ömer; Bilgin, CahitHighway workers, such as policemen, automotive service companies, and toll collectors, are placed at risk of the accelerated atherosclerotic process, since recent studies have suggested that exposure to exhaust particles and ambient air pollution increases carotid intima-media thickness and reduces ocular blood flow velocity. Therefore, we assessed the relationship between serum homocysteine, a potential parameter for atherosclerosis, and the ocular blood flow velocity and the resistivity index in highway toll collectors. The peak systolic and end diastolic flow velocities and the resistivity index were measured in 22 toll collectors and 24 control subjects by color Doppler ultrasonography. The resistivity index, which is an indirect measure of the atherosclerotic process, was calculated: resistivity index = (peak systolic velocity - end diastolic velocity)/peak systolic velocity. Serum homocysteine levels were determined by fluorometric high-performance liquid chromatography. In the highway toll collectors, the serum homocysteine level (14.4 +/- 4.8 mu mol/l; p < 0.005) and the resistivity index of the ophthalmic artery (0.741 +/- 0.015; p < 0.05) were higher and the ophthalmic blood flow velocity (33.0 < 3.0 cm/s; p < 0.001) was lower than those in the controls (10.6 +/- 3.1,mu mol/l; 0.728 +/- 0.023; 36.8 +/- 2.2 cm/s; respectively). There were significant correlations between the serum homocysteine level and ophthalmic artery resistivity index in both highway toll collectors (p < 0.001) and controls (p < 0.005). Exposure to exhaust particles might increase the serum homocysteine level, which in turn could lead to the decreased ocular blood flow and the increased resistivity index.Öğe High-sensitivity C-reactive protein levels in cerebrospinal fluid and serum in severe head injury: Relationship to tumor necrosis factor-alpha and interleukin-6(Churchill Livingstone, 2007) İş, Merih; Coşkun, Abdurrahman; Sanus, Galip Zihni; Tanrıverdi, Taner; Kafadar, Ali Metin; Hanımoğlu, Hakan; Uzan, MustafaRecent studies have demonstrated the role of high-sensitivity C-reactive protein (hsCRP) in inflammatory diseases; however, it is unclear whether this molecule has a role after severe head injury (SHI). Our aim was to evaluate the levels of hsCRP in both cerebrospinal fluid (CSF) and serum from patients after SHI. The study focused on 11 patients with SHI and evaluated CSF and serum levels of hsCRP, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a 10-day period following the head trauma. The values were compared with those from nine control patients, who had normal pressure hydrocephalus. In the CSF and serum of the patients after SHI HsCRP was found to be significantly higher, at all times, than in the controls; TNF-alpha and IL-6 levels were also higher in these patients. However, hsCRP levels did not correlate with either TNF-alpha or IL-6. TNF-alpha and IL-6 increased during the period immediately following the SHI and intrathecal levels were always higher than those of the serum. This study demonstrates for the first time that hsCRP reaches high levels in both CSF and serum in patients with SHI, and it may therefore be used as an inflammatory index. This finding suggests a need for further studies in this area, which are larger in scope than the present study. (c) 2007 Elsevier Ltd. All rights reserved.Öğe In vitro stability of pregnancy-associated plasma protein A(2005) Coşkun, Abdurrahman; Özdemir, İsmail; Yavuz, Özlem; Güler, Selver; Şahin, İbrahim E.Amaç: PAPP-A gebelik süresince trofoblastlardan yüksek konsantrasyonda salınır ve gebeliğin 11.-14. haftalarında Down sendromu ve diğer kromozomal anomalilerin taranmasında kullanılmaktadır. Bu çalışmada PAPP-A’nın in vitro stabilitesini araştırdık. Materyal ve Metot: Kan örnekleri gönüllü gebe kadınlardan alınarak iki gruba ayrıldı. Birinci gruptaki örnekler 2 ilâ 8C’de 7 gün ve ikinci gruptakiler –20C’de 28 gün boyunca bekletildi. PAPP-A ilk grupta her gün, ikinci grupta ise haftada bir kez ölçüldü. Sonuçlar: Gruplarda yapılan ölçümlerde istatistiksel olarak anlamlı bir fark bulunmadı (p0.05). Tartışma: Serum PAPP-A’nın 2 ilâ 8C’de en az 7 gün ve –20C’de ise en az 28 güne kadar stabilitesini koruduğunu ve normal laboratuvar koşullarında bir aya kadar saklanabileceğini düşünmekteyiz.Öğe A new internal quality control chart based on biological variation(Springer, 2008) Coşkun, Abdurrahman; Serteser, Mustafa; Fraterman, Arno; Ünsal, İbrahimThe instruments and analytical methods currently used in clinical laboratories today have better precision and stability than those used in the past. With the development of chemical and immunological methods and instrumentation technology, test precision has increased. However, the application of the Westgard multirule procedure to control sera in the Levey-Jennings chart may not be useful or cost-effective. We devised a new test-specific decision limit for accepting or rejecting runs based on the data of within-subject biological variation and prepared a control chart. We then applied these new limits and control chart to a group of tests performed in our laboratory. With the exception of the tests for albumin, total protein, and calcium, for which desirable performance standards could not be attained with the current technology and methodology, the application of these control limits was cost-effective and convenient. It is estimated that the value of healthy within-subject biological variations is constant, irrespective of the methodology, the area in which the study has been performed, and the number of subjects included in the study. We believe that control limits based on biological variation are reliable and cost-effective, and may be useful in modern and accredited laboratories.Öğe Preanalytical factors for non-HDL cholesterol measurements/Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children(Turkish Soc Cardiology, 2008) Coşkun, Abdurrahman…Öğe Pregnancy associated plasma protein-A and epilepsy(Tubitak Scientific & Technical Research Council Turkey, 2007) Coşkun, Abdurrahman; Özdemirli, Burcu; Memişoğulları, RamazanIn this study, we aimed to investigate the role of pregnancy-associated plasma protein-A (PAPP-A) as insulin-like growth factor binding protein-4 (IGFBP-4) protease in epilepsy patients. We studied 16 epilepsy patients and 10 healthy controls. Serum PAPP-A levels of epilepsy patients (6.8 +/- 3.2 mU/L) were higher than of the control group (5.1 +/- 1.9 mU/L), but the difference was not statistically significant (P > 0.05). We concluded that PAPP-A may increase the bioavailability of insulin-like growth factors (IGFs) due to decreased neurogenesis and synthesis of IGFs in chronically epilepsy patients.Öğe Pregnancy associated plasma protein-A evaluation of a new biomarker in hypothyroidsm(Elsevier Science Bv, 2005) Yavuz, Özlem; Coşkun, Abdurrahman; Duran, S.; Saçlı, S.; Şahin, I.E.; Güler, S.…Öğe Pregnancy-Associated Plasma Protein A and High-Sensitivitive C-Reactive Protein Levels in Chronic Subdural Haematoma Patients(Journal Neurological Sciences, 2011) Hanımoğlu, Hakan; Ulu, Mustafa Onur; Biçeroğlu, Hüseyin; Memişoğulları, Ramazan; Coşkun, Abdurrahman; Balak, Naci; Uzan, MustafaObjective: Pregnancy-associated plasma protein A (PAPP-A), a metalloproteinase that regulates insulinlike growth factor-1 bioavailability in vitro, has been suggested to play an active role in the pathophysiology of several conditions involving inflammatory responses. We investigated the values of PAPP-A and high sensitive CRP (hsCRP) levels in chronic subdural haematoma (CSDH) patients and healthy controls. Methods: PAPP-A and hsCRP levels were studied in the serum and subdural haematoma fluid of 20 consecutive patients with CSDHs (M / F: 12 / 8; mean age of 56.7) and in the serum of age matched 16 volunteers (M / F: 10 / 6; mean age: 54,2). Results: The serum PAPP-A [4.15 ng/mL (2.70-12.88)] levels of patients were significantly lower than control group [9.32 ng/mL (6.57 - 17.00)] (p< 0.01) and the hsCRP levels were significantly higher in patient group [4.57 mg/L (1.56 - 12.62)] (p< 0.01). The comparison of PAPP-A values in the serum and subdural haematoma in the patient group revealed significantly very high values in the subdural fluid [204.5 ng/mL (161.1 - 261.4)] than the serum [4.15 ng/mL (2.70-12.88)] (p < 0.0001). The hsCRP values, on the other hand, were significantly lower in the subdural haematoma fluid than the serum in the patient group (p = 0.016). Conclusion: PAPP-A may have an important function in the local inflammatory events and local structural changes associated with CSDH formation and growth. The detection of high peripheral hsCRP levels in the patient group suggests that a systemic inflammatory response follows after the traumatic insult leading to CSDH formation.
