Does L-carnitine increase serum TNF -alpha and IGF-1 during liver regeneration in the rat?
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: We sought to evaluate the effect of L-carnitine administration on the levels of IGF-1, TNF-alpha, and lipid peroxidation during hepatic regeneration for up to 72 h in an experimental partial hepatic resection rat model. Materials and methods: Sixty rats were divided into 3 groups: control and low-dose (100 mg/kg) and high-close (200 mg/kg) L-carnitine. Each group was divided into 2 sub groups (24 and 72 h after partial hepatectomy). Partial (70%) hepatectomy was performed after 7 days of intra-peritoneal administration of L-carnitine. After partial hepatectomy, L-carnitine was also administered to rats until sacrifice. Serum IGF-1, TNF-alpha, and tissue inalondialdehyde levels were determined in all groups before and at 24 and 72 h after surgery. Results: Serum TNF-alpha increased significantly in the control group during the regeneration period. The low close of L-carnitine (100 mg/kg) decreased the elevation of TNF-alpha whereas the high dose (200 mg/kg) increased it. In the control group, the IGF-1 level decreased in the first 24 h after surgery and then increased. The IGF-1 level behaved similarly in the L-carnitine groups. The inalondialdehyde level in the control group increased during the first 24 h and then decreased. Similarly in the L-carnitine groups, the malondialdehyde level increased during the first 24 h and then decreased significantly in a close-dependent manner. Conclusion: Three types of biochemical pathways are essential in liver regeneration: cytokine, growth factor, and metabolic pathways. We conclude that, in addition to its effects on energy metabolism, high-dose L-carnitine may promote liver regeneration by increasing IGF-1, TNF-alpha, and decreasing malondialdehyde.
Açıklama
Coskun, Abdurrahman/0000-0002-1273-0604;
WOS: 000273310100009
WOS: 000273310100009
Anahtar Kelimeler
Liver regeneration, partial hepatectomy, L-carnitine, TNF-alpha, IGF-1
Kaynak
Turkish Journal Of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
39
Sayı
6
