Does L-carnitine increase serum TNF -alpha and IGF-1 during liver regeneration in the rat?

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dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorZengin, Ahmet
dc.contributor.authorAslaner, Arif
dc.contributor.authorYavuz, Tevfik
dc.date.accessioned2020-05-01T09:11:28Z
dc.date.available2020-05-01T09:11:28Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604;en_US
dc.descriptionWOS: 000273310100009en_US
dc.description.abstractAim: We sought to evaluate the effect of L-carnitine administration on the levels of IGF-1, TNF-alpha, and lipid peroxidation during hepatic regeneration for up to 72 h in an experimental partial hepatic resection rat model. Materials and methods: Sixty rats were divided into 3 groups: control and low-dose (100 mg/kg) and high-close (200 mg/kg) L-carnitine. Each group was divided into 2 sub groups (24 and 72 h after partial hepatectomy). Partial (70%) hepatectomy was performed after 7 days of intra-peritoneal administration of L-carnitine. After partial hepatectomy, L-carnitine was also administered to rats until sacrifice. Serum IGF-1, TNF-alpha, and tissue inalondialdehyde levels were determined in all groups before and at 24 and 72 h after surgery. Results: Serum TNF-alpha increased significantly in the control group during the regeneration period. The low close of L-carnitine (100 mg/kg) decreased the elevation of TNF-alpha whereas the high dose (200 mg/kg) increased it. In the control group, the IGF-1 level decreased in the first 24 h after surgery and then increased. The IGF-1 level behaved similarly in the L-carnitine groups. The inalondialdehyde level in the control group increased during the first 24 h and then decreased. Similarly in the L-carnitine groups, the malondialdehyde level increased during the first 24 h and then decreased significantly in a close-dependent manner. Conclusion: Three types of biochemical pathways are essential in liver regeneration: cytokine, growth factor, and metabolic pathways. We conclude that, in addition to its effects on energy metabolism, high-dose L-carnitine may promote liver regeneration by increasing IGF-1, TNF-alpha, and decreasing malondialdehyde.en_US
dc.description.sponsorshipAbant Izzet Baysal University Department of Scientific and Research, Bolu - TurkeyAbant Izzet Baysal University [2005-07-01-236]en_US
dc.description.sponsorshipThis study was supported by Abant Izzet Baysal University Department of Scientific and Research Projects (2005-07-01-236), Bolu - Turkey.en_US
dc.identifier.doi10.3906/sag-0804-20en_US
dc.identifier.endpage880en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage875en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0804-20
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5614
dc.identifier.volume39en_US
dc.identifier.wosWOS:000273310100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver regenerationen_US
dc.subjectpartial hepatectomyen_US
dc.subjectL-carnitineen_US
dc.subjectTNF-alphaen_US
dc.subjectIGF-1en_US
dc.titleDoes L-carnitine increase serum TNF -alpha and IGF-1 during liver regeneration in the rat?en_US
dc.typeArticleen_US

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