Evaluation of the effects of desflurane and sevoflurane anesthesia on alveolar epithelial permeability by Tc-99m DTPA inhalation scintigraphy

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dc.contributor.authorİskender, Abdülkadir
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorErbaş, Mesut
dc.contributor.authorGüven, Damla Güçlü
dc.contributor.authorSezen, Gülbin
dc.contributor.authorAşık, Muhammet
dc.contributor.authorYıldırım, Mustafa
dc.date.accessioned2020-05-01T12:14:12Z
dc.date.available2020-05-01T12:14:12Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000323610400030en_US
dc.description.abstractAim: Recently studies showed that volatile anesthetics affect the ciliary beat frequency in vitro. We know that impairment of ciliary beat frequency is related to a risk of pulmonary complications with general anesthesia. Other studies have also shown that exposure to a volatile anesthetic can increase the permeability of the alveolar-capillary barrier. The present study aimed to determine the effects of desflurane and sevoflurane anesthesia on the technetium-labeled diethylene triamine penta-acetic acid (Tc-99m DTPA) clearance rate of the alveolar epithelium. Materials and methods: A total of 40 patients who underwent elective tympanoplasty with general anesthesia were included in this study. Patients having any systemic disease or infection, or with any property that affected lung functions, were excluded from the study. Patients were randomized into 2 groups (20 patients in each) as receiving sevoflurane and desflurane. A Tc-99m DTPA aerosol inhalation lung imaging method was used to assess lung functions. Results: Demographic properties were similar in both groups. There were no significant differences between basal and postoperative lung clearance of inhaled Tc-99m DTPA in either group. Conclusion: We propose that neither sevoflurane nor desflurane induces pulmonary alveolar capillary injury in the acute period of general anesthesia based on Tc-99m DTPA scan results.en_US
dc.identifier.doi10.3906/sag-1207-74en_US
dc.identifier.endpage861en_US
dc.identifier.issn1300-0144
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage858en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1207-74
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6320
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323610400030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSevofluraneen_US
dc.subjectdesfluraneen_US
dc.subjectalveolar epithelial permeabilityen_US
dc.subjectTc-99m DTPAen_US
dc.subjectscintigraphyen_US
dc.titleEvaluation of the effects of desflurane and sevoflurane anesthesia on alveolar epithelial permeability by Tc-99m DTPA inhalation scintigraphyen_US
dc.typeArticleen_US

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