The value of FDG-PET/CT by using 3-dimensional stereotactic surface projection software analysis in the differential diagnosis of dementia

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dc.contributor.authorArslan, Esra
dc.contributor.authorEkmekçioğlu, Özgül
dc.contributor.authorGörtan, Fatma Arzu
dc.contributor.authorAkcan, Zeynep Funda Engin
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorEmul, Murat
dc.contributor.authorSönmezoğlu, Kerim
dc.date.accessioned2020-04-30T23:34:38Z
dc.date.available2020-04-30T23:34:38Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSonmezoglu, Kerim/0000-0003-1215-5184en_US
dc.descriptionWOS: 000362526300026en_US
dc.descriptionPubMed: 26738361en_US
dc.description.abstractBackground/aim: To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis. Materials and methods: A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection. Results: Clinic and PET findings were consistent in 20 patients and inconsistent in 14 patients. When consensus diagnosis was taken as the reference, the sensitivity, specificity, accuracy, and positive and negative predictive values of FDG-PET imaging were 93%, 85%, 90%, 90%, and 89% respectively, for AD diagnosis. The same values were 85%, 93%, 90%, 89%, and 90%, respectively, for FTD definition. Conclusion: Using automatized programs that enable quantitative evaluation of regional brain glucose metabolism, in addition to visual evaluation, may increase diagnostic efficiency, as well as minimize interobserver and/or intercenter variability.en_US
dc.identifier.doi10.3906/sag-1403-121en_US
dc.identifier.endpage1158en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1149en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1403-121
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5197
dc.identifier.volume45en_US
dc.identifier.wosWOS:000362526300026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectfrontotemporal dementiaen_US
dc.subjectfluor-18-FDG-PETen_US
dc.subjectbrain positron emission tomographyen_US
dc.titleThe value of FDG-PET/CT by using 3-dimensional stereotactic surface projection software analysis in the differential diagnosis of dementiaen_US
dc.typeArticleen_US

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