beta-lactamase genes in carbapenem resistance Acinetobacter baumannii isolates from a Turkish university hospital

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dc.contributor.authorCoşkun, Umut Safiye Say
dc.contributor.authorÇalışkan, Emel
dc.contributor.authorÇiçek, Ayşegül Çopur
dc.contributor.authorTurumtay, Halbay
dc.contributor.authorSandallı, Cemal
dc.date.accessioned2020-04-30T22:40:08Z
dc.date.available2020-04-30T22:40:08Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000457877600007en_US
dc.descriptionPubMed: 32032023en_US
dc.description.abstractIntroduction: The spread of Acinetobacter baumannii, resistant to most of the available antimicrobial agents, is a serious health problem. The high rate of carbapenem resistance among Acinetobacter baumannii isolates is considered as a threat to public health. In this study, we aimed to determine the antibiotic resistance and related genes in carbapenem-resistant Acinetobacter baumannii isolates. Methodology: Ninety six isolates of A. baumannii were included. Antimicrobial susceptibility was performed by Phoenix Automated System and disk diffusion method. Carbapenem resistane was characterized by scrneeing of resistance genes such as bla(TEM), bla(SHV), bla(CTX-M1-2), bla(PER), bla(VEB), bla(KPC), bla(GES), bla(NDM), bla(VIM), bla(IMP) and bla(OXA23-24-51-58) using multiplex polymerase chain reaction. Results: Resistance for the levofloxacin, gentamicin, amikacin, and tigecycline were determined as 96.9%, 93.7%, 72.9% and 45.8% respectively. Colistin was the only susceptible antibiotic against all clinical isolates. All isolates were defined as multidrug resistance and of these, 31.2% were extensively drug-resistant (sensitive only to colistin). B/aoxA-51 and b/aoxA-23 genes were detected in 100% strains while bla(TEM) was found in only 2% strains. There was no amplification for the bla(SHV), bla(CTX-M1-2), bla(PER), bla(VEB), bla(KPC), bla(GES) bla(NDM), bla(VIM), bla(IMP) and bla(OXA24-58) genes. Conclusions: The high frequency of bla(OXA-23) and low frequency of bla(TEM) gene was observed that indicate prevalence of a variety of A. baumannii strains. The rates of resistance genes vary from region to region. Studies are required for the prevention and control of A. baumannii infection and to formulate the strategies of antibiotic usage.en_US
dc.description.sponsorshipRecep Tayyip Erdogan UniversityRecep Tayyip Erdogan University [2014.102.03.02, 2014.102.03.03]en_US
dc.description.sponsorshipThe authors extend their appreciation to the Recep Tayyip Erdogan University Research Fund Grants for funding this work through the research project No: 2014.102.03.02 and 2014.102.03.03.en_US
dc.identifier.doi10.3855/jidc.10556en_US
dc.identifier.endpage55en_US
dc.identifier.issn1972-2680
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.10556
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2912
dc.identifier.volume13en_US
dc.identifier.wosWOS:000457877600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal Of Infection In Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectmulti drug resistanceen_US
dc.subjectresistance genesen_US
dc.subjectbla(OXA-23)en_US
dc.titlebeta-lactamase genes in carbapenem resistance Acinetobacter baumannii isolates from a Turkish university hospitalen_US
dc.typeArticleen_US

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