The investigation of the molecular changes during lipopolysaccharide-induced systemic inflammation on rat hippocampus by using FTIR spectroscopy

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dc.authoridCakmak-Arslan, Gulgun/0000-0003-4326-1780en_US
dc.authorscopusid57208491698en_US
dc.authorscopusid58971491200en_US
dc.authorscopusid6505884942en_US
dc.authorscopusid7003491843en_US
dc.authorscopusid7004161587en_US
dc.contributor.authorCakmak-Arslan, Gulgun
dc.contributor.authorKaya, Yildiray
dc.contributor.authorMamuk, Soner
dc.contributor.authorAkarsu, Eyup Sabri
dc.contributor.authorSevercan, Feride
dc.date.accessioned2024-08-23T16:07:18Z
dc.date.available2024-08-23T16:07:18Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe aim of this study is to reveal the molecular changes accompanying the neuronal hyper-excitability during lipopolysaccharide (LPS)-induced systemic inflammation on rat hippocampus using Fourier transform infrared (FTIR) spectroscopy. For this aim, the body temperature of Wistar albino rats administered LPS or saline was recorded by radiotelemetry. The animals were decapitated when their body temperature began to decrease by 0.5 degrees C after LPS treatment and the hippocampi of them were examined by FTIR spectroscopy. The results indicated that systemic inflammation caused lipid peroxidation, an increase in the amounts of lipids, proteins and nucleic acids, a decrease in membrane order, an increase in membrane dynamics and changes in the secondary structure of proteins. Principal component analysis successfully separated control and LPS-treated groups. In conclusion, significant structural, compositional and functional alterations occur in the hippocampus during systemic inflammation and these changes may have specific characteristics which can lead to neuronal hyper-excitability.en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1002/jbio.202300541
dc.identifier.issn1864-063X
dc.identifier.issn1864-0648
dc.identifier.issue6en_US
dc.identifier.pmid38531619en_US
dc.identifier.scopus2-s2.0-85189509448en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jbio.202300541
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14581
dc.identifier.volume17en_US
dc.identifier.wosWOS:001190848300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofJournal of Biophotonicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFourier transform infrared (FTIR) spectroscopyen_US
dc.subjecthippocampusen_US
dc.subjectlipid structureen_US
dc.subjectlipopolysaccharide (LPS)en_US
dc.subjectneuronal excitabilityen_US
dc.subjectprotein structureen_US
dc.subjectsystemic inflammationen_US
dc.subjectTransform Infrared-Spectroscopyen_US
dc.subjectThiol Redox Stateen_US
dc.subjectMitochondrial Dysfunctionen_US
dc.subjectSeizure Susceptibilityen_US
dc.subjectIr Microspectroscopyen_US
dc.subjectHypothermic Responseen_US
dc.subjectIonizing-Radiationen_US
dc.subjectProtein Oxidationen_US
dc.subjectNitric-Oxideen_US
dc.subjectHuman-Cellsen_US
dc.titleThe investigation of the molecular changes during lipopolysaccharide-induced systemic inflammation on rat hippocampus by using FTIR spectroscopyen_US
dc.typeArticleen_US

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