Effects of anti-edema drugs on diffuse cerebral edema in rats: Experimental study

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dc.contributor.authorAkyüz, Fevzullah
dc.contributor.authorİş, Merih
dc.contributor.authorAytekin, Hikmet
dc.contributor.authorAnlar, Murat
dc.contributor.authorAkgül, Osman
dc.date.accessioned2020-05-01T09:11:52Z
dc.date.available2020-05-01T09:11:52Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000317152600001en_US
dc.descriptionPubMed: 23599189en_US
dc.description.abstractBACKGROUND Traumatic brain edema is one of the most common problems encountered in neurosurgical practice and it leads to morbidity and mortality via increased intracranial pressure. The aim of this study was to examine the effect of hypertonic saline on traumatic brain edema in comparison to mannitol. METHODS Eighty adult male Sprauge-Dawley rats weighting 300-350 g were used in this experimental study. Rats were randomly divided into control (C); trauma (T); mannitol only trauma+mannitol; NaCl 3% only; Trauma+NaCl 3%; NaCl 7.5% only; trauma+NaCl 7.5%; NaCl 23.4% only and trauma+NaCl 23.4% groups. All medications were given intraperitoneally. Rats were sacrificed and decapitated 24 hours after trauma with or without medications and the brains were examined histopatologically. RESULTS Although no difference was observed with regard to hemorrhage between trauma only and trauma+NaCl 23.4% groups, there was a statistically significant difference in brain edema within these two groups (p=0.003). There were no statistically significant differences within groups with respect to plasma osmolarity and serum sodium levels. CONCLUSION This study demonstrates that 23.4% NaCl is more effective than other concentrations of hypertonic saline or mannitol in the prevention of posttraumatic brain edema. Further clinical studies with different dosages and concentrations of hypertonic saline are required.en_US
dc.identifier.doi10.5505/tjtes.2013.24478en_US
dc.identifier.endpage97en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2013.24478
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5798
dc.identifier.volume19en_US
dc.identifier.wosWOS:000317152600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain edemaen_US
dc.subjecthypertonic salineen_US
dc.subjecttraumatic brain injuryen_US
dc.titleEffects of anti-edema drugs on diffuse cerebral edema in rats: Experimental studyen_US
dc.typeArticleen_US

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